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Biomedical subjects

M Sacher

Publications and source records attributed to M Sacher.

At least 73 records · Page 4Linked to original sources

Differentiation of large suprasellar masses by evaluation of the superior margin.

Differentiation of suprasellar masses by computed tomography criteria depends on intrasellar extension, patterns of calcification and enhancement, associated bony reaction, and cystic changes. In the case of a homogeneously enhancing suprasellar mass that does not exhibit any of these differentiating findings, separating a suprasellar meningioma from a large suprasellar pituitary adenoma has been quite difficult. We reviewed the computed tomography findings of 42 such tumors. There were 19 meningiomas and 23 pituitary adenomas chosen that had few or none of the commonly applied findings used in differentiation. Evaluation of the superior contour of these masses seems a reliable sign to use in this situation. A single upward convex curve correlated with a meningioma in 15 of 19 cases (78%), whereas a multiple upward convex curve correlated with a pituitary adenoma in 19 of 23 cases (82%). Although some pitfalls were encountered when employing this sign--such as pseudolobulations caused by the adjoining cavernous sinus, dural, or vascular structures--it nonetheless led to the correct diagnosis in approximately 80% of cases.

Adenoma↗

Cystic adult medulloblastomas.

The computed tomography scans of four patients who had a medulloblastoma are reviewed. In all the cases, atypical findings were present--specifically, cystic or lucent areas within the tumor. The importance of this uncommon finding associated with adult medulloblastoma is discussed.

Adolescent↗

The postcraniectomy site: CT appearance.

The hospital records and computed tomographic (CT) scans of 124 postcraniectomy patients were reviewed. The normal CT appearance of the operative site was defined and referred to as the "meningogaleal complex" (MGC). The CT characteristics of postoperative infections, intraaxial tumor recurrences, extraaxial tumor recurrences, and the various forms of postoperative cerebrospinal fluid collections were identified and differentiated by comparison with the normal scans. Specifically, when compared with the "postoperative baseline" anatomy, smooth thickening of the MGC often indicated postoperative infection (six cases), while nodular thickening heralded recurrent extraaxial tumor (eight cases). Recurrent intraaxial tumor adjacent to the craniectomy site caused no change in the MGC itself. A knowledge of the normal postoperative appearance of the MGC as well as good communication with the neurosurgeon can allow earlier detection of postoperative complications.

Adult↗

Isolated central nervous system metastasis from transitional cell carcinoma of the bladder: report of a case and review of the literature.

Although systemic metastases from transitional cell carcinoma of the bladder occur frequently, involvement of the central nervous system is uncommon. We describe a patient with an isolated cerebral metastasis who had previously undergone resection of a Grade III, Stage B2 carcinoma of the bladder. We have been able to find only one previous case report of a solitary intracerebral metastasis from transitional cell carcinoma of the bladder without evidence of primary recurrence or additional sites of spread. Central nervous system metastasis from bladder carcinoma must be considered in the differential diagnosis of solitary intracerebral lesions.

Antineoplastic Combined Chemotherapy Protocols↗

[Dwarfism in the Alagille syndrome caused by somatomedin C deficiency?].

Alagille syndrome (= arterio-hepatic dysplasia) is a rare congenital syndrome consisting of cholestasis with paucity of intrahepatic bile ducts, pulmonary artery stenosis, skeletal anomalies and typical facies. Growth retardation, which is not correlated with vertebral anomalies or the degree of cholestasis, occurs in about two thirds of patients. We report on hormonal aspects of growth retardation in an 8 year old Austrian boy with the typical features of arteriohepatic dysplasia. Thyroid function and a cortisol profile were normal and we found normal HGH response to insulin stimulation. The Somatomedin C-activity was well below the age-adjusted normal range. Even after test-induced HGH peaks no increase in Somatomedin C-activity could be observed. A six month course of phenobarbital-, cholestyramine- and D-penicillamine-therapy led to significant improvement of cholestasis, however Somatomedin C values and growth velocity remained unchanged. Results in our patients show that Somatomedin C-deficiency might be an important cause of growth retardation in children with chronic liver disease, at least in arteriohepatic dysplasia.

Bile Ducts↗

[Clinical aspects and course of Sturge-Weber syndrome in childhood].

We report on symptoms, clinical course and prognostic factors of eight children (6 girls and 2 boys) with Sturge-Weber syndrome. The period of observation was 1 to 17 years (mean 8.8 years). All patients had the classical symptoms with facial port-wine stain nevus and intracranial calcifications. In two cases a bilateral distribution of the nevus was found. All patients but one had epileptic seizures which were followed by Todd's palsies in five. Four children additionally suffered from hydrophthalmia. Another patient had an angiomatosis of the retina and cataract. Neurological findings were normal in three patients, minimal signs were found in three, one patient had a spastic hemiplegia and another one hypotone tetraplegia. The mental development was normal in three patients, however severe dyscalculia occurred in one of them. Five patients were mentally retarded, three of them severely. The prognosis was the worse the earlier the cerebral seizures appeared.

Adolescent↗

[Vertical hepatitis B transmission by anti-HBe positive hepatitis B carrier mothers].

5 infants (3 boys and 2 girls) were infected vertically with hepatitis B virus by their healthy anti-HBe positive HBsAg carrier mothers. First sign of infection in the infants occurred 1 to 6 months after birth. The course of the disease was as follows: subclinical hepatitis B (1 case), acute hepatitis B with complete resolution (1 case), fatal fulminant hepatitis B (1 case), chronic persistent hepatitis B (1 case), and chronic active hepatitis with rapid progression to cirrhosis. We conclude that anti-HBe positive hepatitis B carrier mothers may be infective and thus may cause serious, eventually fatal disease in their infants. Passive-active immunization must be given to infants of all hepatitis B carrier mothers irrespective if they are anti-HBe positive or not.

Carrier State↗

[Combined propyphenazone and codeine poisoning in childhood (analysis of 6 patients with Spasmoplus poisoning)].

The case histories are presented of 6 patients with accidental poisoning by Spasmoplus suppositories. The main toxic constituents are codeine and the pyrazolone derivative, propyphenazone. All patients had symptoms of codeine intoxication with somnolence, miosis and oedema, 2 patients had also symptoms of prophyphenazone intoxication with hypotension, coma and convulsions. 1 patient died during the acute stage in a state of shock, with arrhythmia, and asystole.

Aminopyrine↗

[Epidemiology and clinical aspects of Campylobacter enteritis in childhood].

Stool specimens of 478 children with enteritic symptoms were screened for enteropathogenic bacteria over a 5-month period. 28 cases of infection due to Campylobacter jejuni were found. The incidence of Campylobacter enteritis exceeded that of salmonella and shigella infections recorded over the same period (17 and 11 cases, respectively). Infected children-aged between 2 months and 15 1/2 years-presented with symptoms of mild gastroenteritis. 18 patients had bloody diarrhoea, whilst 4 children aged between 4 and 9 years with abdominal pain showed a clinical picture mimicking acute appendicitis. Two severely dehydrated infants required parenteral fluids, but in the remaining cases dietetic treatment alone proved satisfactory.

Adolescent↗

[Epidemiology and clinical course of perinatally acquired hepatitis B infection].

A report is presented on 10 children with perinatally-acquired hepatitis B virus infection. In 9 cases the mother was most probably the source of infection (vertical transmission of hepatitis B), whilst one child was infected via repeated blood transfusion. 7 mothers were of south-eastern European and/or Anatolian origin. Only 2 mothers suffered from clinically apparent liver disease (one had chronic-aggressive hepatitis with positive HBs-antigen and the other had acute hepatitis B). All the others were healthy hepatitis B carriers. Of 7 mothers examined 2 were HBe-antigen positive, and 5 were anti-HBe positive. The clinical course of infection in children varied: 2 children developed subclinical infection, 2 developed acute hepatitis B, which was fulminant with a fatal outcome in one. 6 children showed antigen persistence (HBs-antigen carriers) over the whole period of observation. In one child this antigen persistence is associated with cirrhosis of the liver, 3 children suffer from chronic-persistent hepatitis B, 2 children are healthy carriers; all children are HBe-antigen positive and, thus, seem to be highly infectious. Apart from the risk to the individual, perinatal hepatitis B infection in a certain population. Hence, preventive measures are indicated and should be carried out in form of HBs-antigen screening of pregnant women - at least of high-risk groups - and active-passive immunization of the newborns at risk. The indication for immunization should not depend on the HBe-antigen status of HBs-antigen positive mothers.

Austria↗

Chondrosarcoma of the spine: an unusual radiographic presentation.

Chondrosarcoma is a primary malignant tumor arising rarely in the axial skeleton. It usually presents as a destructive lesion with diffuse mottled calcification. We report three patients with chondrosarcoma of the spine. Each patient was evaluated by conventional radiographic technique, computed tomography, and myelography. All of them show radiographically a purely destructive process of the body and in one case the body and lamina. This pattern remains to be documented in the radiologic literature.

Adult↗

Fructose-1,6-diphosphatase deficiency: glycerol excretion during fasting test.

A Turkish boy had suffered since the age of 10 months from recurrent attacks of severe metabolic acidosis and hypoglycaemia precipitated by moderate respiratory tract infections. A liver biopsy showed lack of fructose 1,6-diphosphatase and absence of phosphorylase. The patient died in shock following fructose ingestion. Upon fasting, acidosis with increased lactate and glycerol excretion was found. Findings indicate that, in this inherited disorder of gluconeogenesis, lactic acidosis combined with increased glycerol excretion upon fasting are of diagnostic importance.

Acidosis↗

Radiology of large transincisural masses.

A large, potentially resectable mass that crosses the tentorial incisura may present unique problems for the neurosurgeon. Fifteen patients with large transincisural extraaxial masses were reviewed. The computed tomography and angiography findings are discussed. The importance of altering the clinician to the presence of a transincisural mass and accompanying computed tomography and angiography findings are emphasized.

Brain Neoplasms↗

Meningioma with intratumoral fat.

Fat within meningiomas is histologically not uncommon. Focal areas of low density on computed tomography scans within meningiomas have been demonstrated and are most often intratumoral cysts. The case presented demonstrates a focal area of low density within a meningioma that is proved histologically to be fat.

Female↗

Total internal carotid artery occlusion by a benign carotid body tumor: a rare occurrence.

A rare case of a carotid body tumor that completely occluded the internal carotid artery is presented. To our knowledge this is only the second such case documented by angiography. In the present computed tomography era, the role of vascular imaging in these tumors is discussed and the varied clinical presentations of these neoplasms are reviewed. The confusion between the locally malignant behavior of some of these lesions and the accepted definition of a malignant carotid body tumor is discussed.

Arterial Occlusive Diseases↗

Extracranial tumor vascularity: determination by dynamic CT scanning. Part II: The unit approach.

Twenty-eight patients had combined conventional drip infusion CT scans. The information about the anatomic location of the lesion, its configuration, its cross-sectional appearance, its vascularity (as determined by dynamic signature curves), and its clinical presentation were considered as a single overall unit. This diagnostic approach allowed a diagnosis to be made on virtually all of these enhancing lesions without resorting to either a digital venous imaging study or angiographic procedure. In 17 of these cases, such an invasive second procedure was performed either to confirm the CT impression as part of this study or as part of a therapeutic embolization procedure.

Adolescent↗

Extracranial tumor vascularity: determination by dynamic CT scanning. Part I: Concepts and signature curves.

Combined conventional drip infusion-dynamic CT scanning was performed on 28 patients with clinically discovered neck or parapharyngeal space masses. Seventeen of these also had digital venous study or angiographic studies either to confirm the CT diagnosis or as part of an embolization procedure. The studies indicate that the initial portion of the dynamic scan curve can be characteristically classified as either an arterial, venous, or hypovascular signature curve. The current ideas of how these curves are generated, the specific appearance of these signature curves, and the types of pathologic conditions that correlate with each curve are discussed.

Angiography↗

Parenchymal cysts of the lower neck.

We report on the appearance of parathyroid, thyroid, and cervical thymic cysts on computed tomography (CT) scans. The differential diagnostic considerations include thyroglossal and branchial cleft cysts, cystic hygromas, primary and metastatic tumors, dermoids, teratomas, choristomas, tracheoesophageal and cervical bronchogenic cysts, as well as cystic neuromas, abscesses, and lipomas. Most cannot be differentiated using CT alone and require clinical observations, laboratory testing, and surgical and histologic findings for definitive diagnosis. Our experience with these rare lesions is reported, and the differential diagnoses are discussed.

Branchioma↗