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Biomedical subjects

M Sabău

Publications and source records attributed to M Sabău.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Cellular electric potentials in experimental cardiac hypertrophy].

Myocardial hypertrophy is considered as an adaptive mechanism of the heart submitted to mechanical overload manifested by an increase of ventricular mass. For the study of the myocardial hypertrophy different experimental models were proposed although the transposition of the results in clinical conditions is difficult. In the adaptive mechanisms of the heart of great importance are the electro-mechanical interrelations. Mechanical alterations during cardiac hypertrophy are characterized by a reduced shortening velocity and an increase of the time to peak tension. They are due to the prolongation of action potential duration especially of its plateau and a decreased rate of repolarization because of the increase of the peak ICa and ICa density, and the slower inactivations of the maximal ICa. Abnormalities of the K+ currents IK1 and IK may contribute to the prolongation of action potential duration. The instability of Ca2+ transients in hypertrophic myocardium can cause the apparition of cardiac arrhythmias.

Action Potentials↗
PubMedDate not supplied

[Age related electrophysiological modifications in rat myocardium].

During aging the electrical and mechanical phenomena of the heart are impaired. We studied the effect of aging using standard microelectrode technique on action potentials obtained in papillary muscle from 1, 3, 6 and 18 month old rats. The action potential of myocardial cells is significantly prolonged and changes resemble those observed during cardiac overload. The possible cause of the slower action potentials is the alteration of Ca2+ transients due to a reduced rate of Ca2+ sequestration by the sarcoplasmic reticulum associated with a possible alteration of K+ currents. These developmental changes are considered as an expression of adaptation of the heart with aging.

Action Potentials↗
PubMedDate not supplied

[Distribution of subtypes of viral hepatitis B antigen in areas of Rumania].

The results of subtyping the B antigen in 551 sera from patients with viral hepatitis, chronic evolutive hepatitis and cirrhosis, chronic carriers, donors and healthy subjects, were confirmed as positive HBAg by diffusion in agar, counterelectrophoresis and radioimmunology, and characterized by the d-y and w-r determinants by rheophoresis. The high incidence of the y determinant in all nine counties investigated probably reflects the prevalence of this serotype in Romania, recalling the distribution of subtypes observed in the south of Europe.

Adolescent↗
PubMedDate not supplied

[Retroperitoneal appendicular abscess].

This article presents a 28 years old male patient case with a retroperitoneal collection of apendicular origin. After few comments about clinical and paraclinical aspects, the authors emphasise the particular aspects of differential diagnosis and surgical approach which, finally, lead to a full recovery of the patient.

Abscess↗