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Biomedical subjects

M Saab

Publications and source records attributed to M Saab.

50 records · Page 3Linked to original sources

Clinical and serological comparison of 17 chronic progressive systemic sclerosis (PSS) and 17 CREST syndrome patients matched for sex, age, and disease duration.

This study compares the clinical and serological differences between 17 PSS and 17 carefully matched CREST patients. Patients were matched for sex, age by decade, and, importantly, disease duration (11.2 +/- 9.2 vs. 12.0 +/- 9.3 years). Muscular and skin involvement were greater for the PSS groups (p less than 0.02) and pulmonary involvement was also greater (p less than 0.05), at least for non-smoking PSS patients. On the other hand no clinically significant differences were found between groups for other visceral involvement--including comparisons of gastrointestinal, cardiovascular, and renal involvement. There were also no laboratory differences except in anti-RNP antibody (p less than 0.04).

Adult↗

Control of gastric acidity by glycopyrrolate premedication in the parturient.

The effect of premedication with the anticholinergic quaternary ammonium compound, glycopyrrolate (0.4 mg), on gastric juice pH was investigated in 23 parturients scheduled for elective cesarean section under general anesthesia, and the results were compared to a control group of 15 nonpremedicated obstetric patients and 25 parturients premedicated with atropine (0.6 mg). In the nonpremedicated control group, the mean gastric juice pH was 2.36 (SE +/- 0.23), 66% having a pH less than the critical level of 2.5. Premedication with atropine did not significantly increase the gastric pH, while in those premedicated with glycopyrrolate, the mean pH increased to 3.7 (+/- 0.35), and the incidence of pH less than the critical level dropped to 34%. The effect of glycopyrrolate on gastric juice pH was significantly increased when the premedication-induction time was prolonged to 60 to 120 minutes. It was concluded that glycopyrrolate premedication can be used in the parturient as an additional measure to safeguard against acid-aspiration syndrome.

Anesthesia, Obstetrical↗

[Thrombolytic treatment of obstructions of mechanical valve prostheses. Apropos of 4 cases and analysis of the literature].

The obstruction of the mechanical valve prothesis (OMVP) is a serious complication. The treatment of this complication was classically surgical. Recently, the thrombolytic treatment was introduced as an alternative approach for patients with high perioperative risk and for those in whom the mechanism of the obstruction is a recently formed thrombus. The authors report four cases of OMVP treated by a thrombolytic agent (Streptokinase, SK, Streptase). Immediate success was obtained in all theses four cases. One late recurrence with fatal issue was noted. All four prostheses were Saint Jude medical (SJM), three in mitral and one in aortic position respectively. The details of the clinical presentation (acute or progressive dyspnea) as well as the contribution of the echocardiography to the diagnosis were presented. The evolution of this therapeutic approach and the international recommendations were reviewed.

Adolescent↗

It's not cricket.

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Bone Cysts↗

Blunt laryngeal trauma: an unusual case.

Local external evidence of neck trauma--bruising, subcutaneous emphysema, cuts, abrasions and so on--signs of upper airway obstruction, dysphonia and dysphagia are the hallmarks of laryngotracheal lesions. Such lesions tend to occur after motor vehicle accidents and usually require surgery. We describe a case of blunt laryngeal trauma, resulting from an unusual mechanism, which healed spontaneously.

Adolescent↗

Fatal septicaemia in a previously healthy man following a dog bite.

A rare case of fatal septicaemia after a dog bite in a previously healthy individual is presented and discussed. Capnocytophaga canimorsus (DF-2 bacterium) was isolated from blood cultures. Our case shows the importance of immediate antibiotic treatment for all dog and cat bites, regardless of severity.

Animals↗