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Biomedical subjects

M S Victoria

Publications and source records attributed to M S Victoria.

At least 19 recordsLinked to original sources

Isoproterenol infusion in the management of respiratory failure in children with status asthmaticus: experience in a small community hospital and review of the literature.

Between January 1985 and December 1988, a total of 701 children were admitted to The Methodist Hospital, Brooklyn, NY for treatment of acute asthma. Eleven of these patients (age range between 8 months and 15 years) went into respiratory failure. All cases of respiratory failure were successfully treated with intravenous isoproterenol. Only one patient needed mechanical ventilation. Treatment with isoproterenol was safe and effective without any complications. We present our experience in the use of isoproterenol in treating children with respiratory failure secondary to status asthmaticus. A brief review of the literature is included.

Adolescent↗

Comparison between epinephrine and terbutaline injections in the acute management of asthma.

A randomized clinical trial comparing subcutaneous epinephrine and terbutaline injections was conducted in asthmatic children at The Methodist Hospital, Brooklyn, New York. Clinical evaluation using the Asthma Scoring System was done at baseline and serially, every 15 minutes, following injection of either drug. Reversal of wheezing, and changes in respiratory and heart rates were assessed using strict a priori criteria. The patients' differential response to both drugs was assessed by a crossover study when the same patients came subsequently for another episode of wheezing. Our results show terbutaline to be more efficacious at a dose comparable to epinephrine dose.

Asthma↗

Hydrocarbon poisoning: a review.

This article reviews the mechanisms of pulmonary injury associated with hydrocarbon poisoning. The evolution of clinical and radiographic changes is discussed, along with appropriate treatment. Preventing aspiration in the emergency department is the most effective therapy for these children in the first few hours after ingestion.

Accidents, Home↗

A continuing study of primary drug-resistant tuberculosis among children observed at the Kings County Hospital Medical Center between the years 1961 and 1980.

A 20-yr prospective study of the incidence of primary drug-resistant tuberculosis among children treated at the Kings County Medical Center was undertaken in January 1961 and extended through December 1980. There were 355 strains of Mycobacterium tuberculosis isolated during this time, 56 of which were found to be primarily resistant to one or more antituberculosis drugs, giving an overall resistance rate of 15.8%. The study was divided into five 4-yr periods. The resistance rate to isoniazid was 9.9%, varying from a peak of 15.2% in the third period of study (1969 to 1972) to 4.5% in the last period of study. The changes in the rate were not significant. The overall resistance rate for streptomycin was 9.2%. There were significant increases in the resistance rate in the second (1965 to 1968) and third (1969 to 1972) periods of study, but not in the last 2 periods. The rates for PAS (3.4%), rifampin (1%), and ethambutol (0.7%) were low. The type and severity of disease among those infected with a resistant strain were no different from those infected with a susceptible strain. Life-threatening disease was found in 10 of the 56 patients infected with a drug-resistant strain. There was one fatality in a child with meningitis who was treated early in the study. Our experience suggests that rifampin and ethambutol be included in the initial treatment regimen of all children with a life-threatening form of tuberculosis until the susceptibility pattern of the infecting strain is determined, after which the drug regimen can be modified if necessary.

Aminosalicylic Acid↗

Persistent postpneumonic pneumatoceles in children.

Ten children who had developed pneumatoceles during the course of pneumonia are described. Seven of the ten patients had persistence of pneumatoceles for 12 months or more. There was no evidence of an underlying disorder in any of the patients, and all recovered completely without complications. The etiologic agent was identified in two of the ten cases as Staphylococcus aureus. In our experience, a delay in the resolution of pneumatoceles for a period of one or more years after an episode of pneumonia is not an unusual occurrence in normal healthy children.

Ampicillin↗

Persistently negative tuberculin reactions: their presence among children with culture positive for Mycobacterium tuberculosis (tuberculin-negative tuberculosis).

Mantoux tests were performed on 200 children with culture-proven Mycobacterium tuberculosis infections. A group of 28 patients initially had negative reactions to 5 TU PPD-S. Of these, 17 had had extensive or overwhelming tuberculous disease at the time of admission, seven of whom reacted to 250 TU PPD; after a course of chemotherapy, all the survivors had positive reactions to 5 TU PPD-S. The 11 with less severe disease had negative reactions to 5 TU PPD-S and 250 TU PPD, as well as to PPD-A/B/G; in only two could a ready explanation be found for the negative reactor state. In general, a small number of children without life-threatening forms of tuberculosis may have persistently negative tuberculin reactions without any apparent cause. In such cases, other criteria for diagnosis must be relied on, such as lymphocyte transformation, culture, and biopsy.

Adolescent↗

Primary drug resistance in children. Drug susceptibility of strains of Mycobacterium tuberculosis isolated from children during the years 1973 through 1977 at the Kings County Hospital Center of Brooklyn.

A continuing study of the frequency of primary drug resistance among children treated at the Kings County Hospital Center of Brooklyn during the years 1973 through 1977 showed a high incidence of primary drug resistance to isoniazid (8.8 per cent) and to streptomycin (12.3 per cent). In contrast, there were no strains resistant to cycloserine, viomycin, ethambutol, or rifampin, and only one of 57 strains (1.8 per cent) was resistant to ethionamide, and one (1.8 per cent) was resistant to para-aminosalicylic acid. Comparison with previous studies begun in 1961 showed no significant increase in resistance to isoniazid during 3 prior periods of study and no increase in resistance to streptomycin during the last 2 periods of study. It must be emphasized that these findings relate only to the children of a local community, and do not reflect the prevalence of primary drug resistance elsewhere in this country or among different age groups.

Adolescent↗

A two-year experience with cromolyn sodium in children with asthma.

A two-year experience with cromolyn sodium in children with asthma drawn from inner city population, is presented. Though the initial response to the drug at six weeks was excellent, the response over a two-year period was only very moderate. The possible reasons for this are discussed.

Asthma↗

Miliary tuberculosis in two infants after nursery exposure: epidemiologic, clinical, and laboratory findings.

Two infants born 4 days apart, and cared for in the same nursery, developed miliary tuberculosis at 2.5 and 5.5 months of age, respectively. A search for a source case among household contacts failed to reveal anyone with active tuberculosis. An epidemiologic study of nursery personnel revealed a nurse's aide with cavitary tuberculosis. Examination of 1,647 infants (98.9 per cent of all infants cared for in the nursery during the 10.5-month period preceding the discovery of the source case) failed to reveal any other infected children. Recommendations are made for tuberculosis control programs among nursery personnel that should be carefully and persistently followed.

Adult↗