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Biomedical subjects

M S Turner

Publications and source records attributed to M S Turner.

63 records · Page 4Linked to original sources
PubMed1982

Neurologic effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs.

The purpose of this study was to evaluate the neurologic consequences of deliberate subarachnoid injection of large volumes of 2-chloroprocaine-CE in experimental animals. The possible role of low pH as well as total volume as potential factors in causing neurotoxicity was evaluated. The 65 dogs in the study received injections in the subarachnoid space as follows: 6 to 8 ml of bupivacaine (N = 15), 2-chloroprocaine-CE (N = 20), low pH normal saline (pH 3.0) (N = 20), or normal saline (N = 10). Of the 20 animals that received subarachnoid injection of 2-chloroprocaine-CE seven (35%) developed hind-limb paralysis. None of the animals that received bupivacaine, normal saline, or normal saline titrated to a pH 3.0 developed hind-limb paralysis. Of the 15 spinal cords of the animals that received 2-chloroprocaine-CE, 13 showed subpial necrosis; the nerve roots and subarachnoid vessels were normal. The spinal cords of the animals that received bupivacaine, low pH normal saline (pH 3.0), or normal saline did not show abnormal findings.

Anesthesia, Epidural↗
PubMed1981

The effect of tibial torsion of the pathology of the knee.

Measurements of tibial torsion using a tropometer were made in more than 1200 consecutive patients attending an adult knee clinic. In total 1672 readings from 836 patients in 11 diagnostic categories were analysed. Patients with either patellofemoral instability or Osgood-Schlatter disease had a significant increase in lateral tibial torsion. The most important finding was a significant reduction in this torsion in patients with panarticular disease.

Adult↗
PubMedDate not supplied

Analysis of promoter sequences from Lactobacillus and Lactococcus and their activity in several Lactobacillus species.

Promoter-active fragments were isolated from the genome of the probiotic organism Lactobacillus rhamnosus strain GG using the promoter-probe vector pNZ272. These promoter elements, together with a promoter fragment isolated from the vaginal strain Lactobacillus fermentum BR11 and two previously defined promoters (Lactococcus lactis and Lactobacillus acidophilus ATCC 4356 slpA), were introduced into three strains of Lactobacillus. Primer-extension analysis was used to map the transcriptional start site for each promoter. All promoter fragments tested were functional in each of the three lactobacilli and a purine residue was used to initiate transcription in most cases. The promoter elements encompassed a 52- to 1,140-fold range in promoter activity depending on the host strain. Lactobacillus promoters were further examined by surveying previously mapped sequences for conserved base positions. The Lactobacillus hexamer regions (-35: TTgaca and -10: TAtAAT) closely resembled those of Escherichia coli and Bacillus subtilis, with the highest degree of agreement at the -10 hexamer. The TG dinucleotide upstream of the -10 hexamer was conserved in 26% of Lactobacillus promoters studied, but conservation rates differed between species. The region upstream of the -35 hexamer of Lactobacillus promoters showed conservation with the bacterial UP element.

Animals↗
PubMedDate not supplied

Measuring the diabetes knowledge of nurses in long-term care facilities.

A knowledge test was developed by a local diabetes educators' group to evaluate the diabetes knowledge base of 59 nurses currently employed in four long-term care facilities in eastern North Carolina. The test contained items in the following categories: monitoring, medication, hypoglycemia, hyperglycemia, illness care, diet, exercise, foot care, and patient/family education. The results of the diabetes knowledge test were analyzed according to overall test scores as well as scores in each of the selected categories. The overall scores ranged from 42% to 89%, with a group mean of 67% (passing = 70% or higher). The scores in the individual categories ranged from 18.6% for monitoring and 23.8% for medications to 91.5% for patient/family education.

Diabetes Mellitus↗
PubMedDate not supplied

Pseudo-spinal headache.

BACKGROUND AND OBJECTIVES: Myofascial trigger points are often not considered in the differential diagnosis of headaches. METHODS: A patient who presented with severe bifrontal headaches was treated by injections of the sternocleidomastoid muscle trigger points with local anesthetics. RESULTS: The patient experienced complete resolution of all symptoms, which had not reappeared after 14 months. CONCLUSIONS: Myofascial pain may mimic other disorders, and myofascial headaches can be easily treated once properly diagnosed.

Adult↗