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Biomedical subjects

M S Su

Publications and source records attributed to M S Su.

62 records · Page 4Linked to original sources
PubMed1994

Temporal lobectomy in adults with intractable epilepsy.

We report on 30 adult patients with intractable complex partial seizure (CPS) of the temporal lobe origin who received anterior temporal lobectomy. The average follow-up period was 41 months. The age of onset was younger and the duration of epilepsy was longer in the non-mass lesion group than in the mass lesion group. Postoperatively, 21 patients (70%) were seizure-free, four patients (13%) had only rare seizures (less than three attacks per year), three patients (10%) achieved a remarkable reduction (more than 50%) of seizure frequency, and two patients (7%) showed no worthwhile improvement. Based on our experience, anterior temporal lobectomy is an effective and safe procedure for adult patients with intractable CPS. For diagnosis, magnetic resonance imaging (MRI) yielded a higher sensitivity rate than computed tomography (CT), especially in the group without mass lesions. Positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) was superior to single photon emission computed tomography (SPECT) which had a relatively high false localization rate. With high resolution MRI and FDG-PET, localization of the epileptogenic zone was more accurate. A preresection electrocorticogram (ECoG) was used to confirm the epileptogenic focus during the operation. The residual spikes on the postresection ECoG did not necessarily predict a poor seizure control outcome after anterior temporal lobectomy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Creutzfeldt-Jakob disease. Report of a case of the panencephalopathic type and experiences of a teaching hospital in Taiwan.

We report a case of the unusual panencephalopathic type of Creutzfeldt-Jakob disease (CJD) in Taiwan. This 59-year-old woman presented in 1983 with typical clinical manifestations of CJD and died 16 months later. Postmortem examination revealed severe neuronal loss, spongiosis and gliosis extensively in cerebral cortex and striatum as well as in the white matter. We also report 6 other CJD patients seen from 1983 to 1991 at Veterans General Hospital-Taipei.

Aged↗
PubMed1992

[Motor evoked potentials in patients with cervical spondylotic myelopathy].

We applied somatosensory and motor evoked potential studies to investigate patients with cervical spondylotic myelopathy (CSM) diagnosed clinically and roentgenographically. There were 32 consecutive cases collected, including 25 males and 7 females, at an average age of 62 +/- 8.2 (49-75) years. A control group consisted of 30 healthy subjects matched in body height and age with patients. The normal values of head-to-neck and head-to-lumbar region central motor conduction times (CMCTs) were 7.04 +/- 0.60 (6.1-8.2) and 15.94 +/- 1.23 (14.0-18.7) ms, which were not affected by body height. The somatosensory evoked potential (SEP) findings were related to clinical posterior column signs, levels of cord lesion, and nerves tested. The abnormality rate of median nerve SEP was relatively low, 53% (17/32), particularly for the lesion below C5-6 level in which median nerve SEP was usually normal. The abnormality rates of ulnar and tibial nerve SEPs were up to 84.5% (27/32) and 90.6% (29/32) respectively. However, median, ulnar and tibial nerve SEPs were normal in 3 (9.4%) patients showing normal posterior column function clinically. Only 18 (56.3%) patients had recordable motor evoked potential (MEP) from abductor digiti minimi (ADM) to head stimulation. The head-to-neck CMCT, 9.12 +/- 1.53 (6.3-12.7) ms, was significantly prolonged. Of these 18 cases there were 9 cases of delayed CMCT with reduced MEP amplitude, 4 of delayed CMCT, 3 of reduced MEP amplitude, and 2 of normal CMCT and MEP amplitude. The remaining 14 cases (43.7%) showed absent MEP from ADM to head stimulation. The overall abnormal rate of MEP from ADM was 93.8% (30/32). MEP from tibialis anterior (TA) to head stimulation was recorded only in 6 patients in whom the responses were all abnormal. There was no response recorded from TA in the remaining 26 CSM patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1990

Activation of epileptogenic activities by etomidate in electrocorticoencephalography (ECoG) during operation for epilepsy.

Epileptic surgery is a radical and ablative treatment for medically refractory epilepsy. Electrocorticoencephalography (ECoG) obtained by subdural strip electrodes should always be used during operation for precise localization of epileptic focus and mapping the extent of its involvement. But difficulties and ambiguities exist when the patient's ECoG is suppressed, either owing to the anticonvulsant used, being at the stage of posterictal period, or the effects of anesthetics during operation. Then, intentional activation of epileptogenic activity should be performed to locate the pathological focus in order to accomplish a successful surgical treatment. Etomidate has been considered as an abnormal electroencephalogram (EEG) activator and its use is not recommended in patients with epilepsy. But lesser dose of etomidate as an activator for ECoG has not been investigated. The study reported here established that etomidate as an hypnotic has not only anesthetic properties but, paradoxically, also activates epileptogenic activity. With the latter pharmacologic characteristic, etomidate can be used to deliberately activate the spikes of the potentially epileptogenic tissue, the delineation and localization of which may help the surgeon determine to what extent the pathological cortex be resected in surgical treatment of a refractory epilepsy. The current recommended dosage of etomidate at veterans General Hospital-Taipei for ECoG in epileptic surgery is 0.1-0.15 mg/kg/iv.

Adolescent↗
PubMed1983

Aprosodia in Chinese patients with right cerebral hemisphere lesions.

Recent publications, all involving native speakers of English, have established that lesions in the right cerebral hemisphere produce a deficit in the comprehension and execution of tonal change in language related to the affective component of prosody. We tested 12 Chinese patients with right-hemisphere lesions and seven controls for comprehension, discrimination, repetition, and expression of prosody and gesture. In 11 of the 12 patients, aprosodia was identified. The subjects were also tested for their ability to detect semantic tonal difference in Chinese. Only five of the 12 showed a mild deficit in this task, suggesting that the left cerebral hemisphere is more dominant for comprehension of tone essential to word meaning.

Adult↗