Biomedical subjects

M S Roos

Publications and source records attributed to M S Roos.

21 records · Page 2Linked to original sources

PubMedDate not supplied

MR image-guided control of cryosurgery.

Cryoablation has recently become a useful procedure for the treatment of prostatic and hepatic tumors, primarily because of advances in the ability to monitor visually the freezing process with ultrasound. Success of the procedure depends in large part on how well the ice front can be positioned to destroy pathologic tissue, while sparing healthy tissue. This study describes a cryogen delivery system that can be used in conjunction with magnetic resonance (MR) image-guided cryoablation, and an automatic control system that uses MR image guidance in a feedback loop to control the ice front trajectory. Edge-detected MR images are used to determine the current ice front location at each time interval, providing feed-back to an automatic control system that adjusts the flow of cryogen to the cryoprobe. Numerical simulations and experimental results demonstrate that an ice front with cylindrical symmetry can be accurately controlled using this MR image-guided feedback control scheme.

Cryosurgery↗

PubMedDate not supplied

Human corpus callosum in aging and Alzheimer's disease: a magnetic resonance imaging study.

The involvement of the corpus callosum in aging and Alzheimer's disease (AD) is not clear. We measured cross sectional areas of the entire corpus callosum (CC), as well as the front 20% (genu), middle 60% (body), and posterior 20% (splenium) of the structure from a midsagittal MRI slice in AD patients (N = 20), and young (N = 16) and old (N = 13) control subjects. We found that mean CC area in young controls was 570 +/- 107 mm2. Aging did not significantly affect the mean area of the CC (562 +/- 98 mm2). A small, significant reduction was seen in AD in comparison to the young control group (480 +/- 133 mm2). However, AD is accompanied by a large and statistically significant reduction in the genu area in comparison to both young and old control subjects. A trend toward an age-dependent reduction in the body area is also accentuated in AD patients who showed significantly smaller callosal bodies than young controls. We conclude that selective changes within corpus callosum accompany aging and AD pathology.

Adult↗

PubMedDate not supplied

PET studies of cerebral glucose metabolism in conscious rhesus macaques.

A growing body of evidence suggests that rhesus macaques may be a good model of human brain aging. We used positron emission tomography (PET) and 18F-fluorodeoxyglucose (FDG) to measure regional cerebral metabolic rates for glucose (rCMRglc) in young and aged rhesus macaques to determine if age-related decreases, such as those reported in humans, also occur in macaques. Whereas the aged animals had lower metabolic rates in every brain region studied, the largest differences were in left temporal cortex. The largest differences were also observed in left temporal cortex when relative rCMRglc values were used. Both rCMRglc and relative rCMRglc were marked by substantial individual variation within the aged group. This variation may parallel the variation observed in behavioral studies. Future studies that include both PET and behavioral measures should help determine if there is a relationship between age-related changes in rCMRglc and behavior.

Aging↗