Dominant lethal effects of triflupromazine in hybrid C3D2F 1 -J mice.
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Animals↗
Biomedical subjects
M S Legator
Publications and source records attributed to M S Legator.
A collaborative study of in vivo cytogenetic analysis. I. Interpretation of slide preparations.
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Administration, Oral↗
Environmental mutagenesis and repair.
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Acridines↗
Hexachlorophene-induced alterations in the metabolism of cultured human lung cells.
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Cell Division↗
Effects of hycanthone on spermatogonial cells, deoxyribonucleic acid synthesis in bone marrow and dominant lethality in rats.
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Animals↗
Photoactivation of chlorpromazine: cytogenetic and mutagenic effects.
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Animals↗
Method for preparing anaphase figures from rat bone marrow.
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Animals↗
Dominant-lethal effects of cyclohexylamine in C57 B1-Fe mice.
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Amines↗
Cytogenetic effects of DDT and derivatives of DDT in a cultured mammalian cell line.
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Animals↗
Mutagenicity of N-nitrosopiperazines for Salmonella typhimurium in the host-mediated assay.
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Animals↗
Deficiencies in our present protocol for chemical evaluation and possible remedies.
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Abnormalities, Drug-Induced↗
Mutagenicity of N-nitrosomorpholine in the host-mediated assay.
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Administration, Oral↗
Induction by N-methyl-N'-nitro-N-nitrosoguanidine and UV light of petite mutants in aerobically and anaerobically cultivated Saccharomyces cerevisiae.
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Crosses, Genetic↗
In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.
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Aflatoxins↗
Mutagenic effects of aflatoxin.
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Abnormalities, Drug-Induced↗
Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.
Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.
Amines↗
Cycasin: detection of associated mutagenic activity in vivo.
Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.
Animals↗