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Biomedical subjects

M S Kuravskaia

Publications and source records attributed to M S Kuravskaia.

3 recordsLinked to original sources
PubMed1986

[Interaction of fibronectin with polymorphonuclear leukocytes normally and in anaphylaxis].

Fibronectin is known as an opsonic glycoprotein possessing a wide range of specificity. Fibronectin interaction with neutrophils (normal ones and those obtained at peak of anaphylactic shock) was studied. Neutrophils were brought in contact with purified homologous fibronectin previously bound to gelatin-Sepharose granules. The presence of fibronectin-binding proteins on the surface of human and rabbit neutrophils was demonstrated, the binding being strongly dependent on Ca2+ and especially Mg2+ ions. "Anaphylactic" neutrophils, in contrast to normal ones, did not interact with fibronectin, which may be important for the pathogenesis of the immediate type hypersensitivity reactions.

Anaphylaxis↗
PubMed1982

[Fibronectin and fibronectin receptors on the surfaces of polymorphonuclear leukocytes].

Interaction between human neutrophils and fibronectin bound to gelatin-Sepharose granules was studied. It was found that fibronectin following cell-induced dissociation from gelatin-Sepharose caused neutrophil aggregation which was inhibited by EDTA or pretrypsinization of the cells. Besides, polymorphonuclear lymphocytes were found to be capable to adhere to and to spread on gelatin-Sepharose granules. This process was enhanced in the presence of heparin and inhibited by neutrophil pretrypsinization. The conclusion has been drawn on simultaneous existence of fibronectin and fibronectin receptors on the surface of neutrophils. A hypothesis is advanced of the existence in the fibronectin molecule of two independent binding sites, one being responsible for cell attachment and the other for gelatin binding.

Fibronectins↗