Biomedical subjects

M S Ho

Publications and source records attributed to M S Ho.

83 records · Page 5Linked to original sources

PubMed1986

Disseminated rhinosporidiosis.

This paper reports a case of rhinosporidiosis which presented with widespread subcutaneous nodular lesions which failed to respond to surgical excision or to intravenous amphotericin B. Lesions in sites away from the nasal cavities are usually believed to be brought about by direct infection or by fingerborne autoinoculation. In this case, haematogenous dissemination was shown by the presence of sporangia within the lumen of a blood vessel. Systemic rhinosporidiosis is an extremely rare condition.

Blood Vessels↗

PubMed1986

Liver biopsies from psoriatics treated with methotrexate.

To study the effects of Methotrexate (MTX) on the liver, light microscopic examination of liver biopsies from 18 consecutive patients with moderate to severe psoriasis receiving MTX seen between 1981-1985, were carried out. All patients received MTX (mean dosage of 1808 gm, mean duration of 88 months) prior to biopsy. There were 12 males, 6 females, with mean age of 55.1 yrs (range 39-77 yrs). All patients were HBsAg negative, non diabetic, and with no significant drug history or alcohol intake. Twenty liver biopsies were examined. Attempts to correlate severity of histological changes to dosage and duration of MTX therapy; and to the levels of raised SGPT at biopsy, failed to show any definite relationship. A variety of histological changes were seen in liver biopsies of MTX treated psoriatics, with 2 patients showing progression of histological changes following repeat biopsy.

Adult↗

PubMed1983

Ergometric heart rate, blood pressure and work capacity (PWC170) in type I diabetics with diabetes-specific microangiopathy.

118 male and 68 female type I diabetics and 25 male and 23 female nondiabetic healthy controls were compared during submaximal bicycle ergometer tests using four work stages (duration: 6 min each) of 50 W, 75 W, 100 W and a submaximal stage producing a heart rate of 170 min-1. We found that male type I diabetics with and without retinopathy who had significantly higher than normal heart rates both at the start and during the ergometer test also had above normal ergometric blood pressures. Female type I diabetics, in contrast, did not differ significantly from the controls in terms of heart rate before and during the ergometer tests. The PWC170 of all male type I diabetics was, in contrast to that of the female patients, lower than that of the controls. In diabetics with diabetic nephropathy there was no correlation between exercised acceleration of the heart rate and the degree of nephropathy despite their higher heart rates at the beginning and during the ergometer test, but a correlation was found between the ergometrically increased blood pressure and the severity of the diabetic nephropathy. In male type I diabetics cardiocirculatory adaptation to muscular work was reduced, and this reduction became more marked as the degree of diabetic microangiopathy increased. Compared with the controls, the increase in systolic blood pressure evoked by activity on the ergometer in male and female type I diabetics was disproportionate to the actual load and correlated with the degree of diabetic microangiopathy.

Adult↗

PubMed1982

Analyses of nicotine and cotinine in tissues by capillary gas chromatography and gas chromatography-mass spectrometry.

Selective extraction and chromatographic techniques have been developed to measure low nanogram quantities of nicotine and cotinine in tissues. Analyses were performed by capillary column gas chromatography with a specific nitrogen-phosphorus detector and by gas chromatography-mass spectrometry. With close structural analogues for internal standards, high quantitative accuracy and precision were demonstrated for the range 5-1000 ng per g of tissue. The sensitivity limit was 2-3 ng/g for both compounds. The advantage of these techniques compared to previously published methods is increased selectivity; the other methods were developed for analysis of biological fluids and are not readily adaptable to more complex biological matrices such as tissue homogenates. With the newly developed techniques, we were able to perform a pharmacokinetic study of nicotine and cotinine in mouse liver following a single intraperitoneal injection of nicotine.

Animals↗

PubMed1982