Single-stage coronary angiography and angioplasty: a new standard.
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Angioplasty, Balloon, Coronary↗
Biomedical subjects
M S Gotsman
Publications and source records attributed to M S Gotsman.
Influence of coronary angioplasty on the progression of coronary atherosclerosis.
This study examines the effect of coronary angioplasty on the progression and appearance of new disease in sites of the coronary tree that were not dilated by the balloon. We examined 355 pairs of coronary angiograms from 252 patients. The study consisted of consecutive patients who were referred for catheterization > 1 month after successful angioplasty. Progression/regression and the appearance of new narrowings at sites not dilated by angioplasty were determined. The life-table method was used to determine outcome, and any event (progression, regression, and new narrowing) was analyzed according to the time of occurrence. The angioplasty artery was compared with the non-angioplasty artery and the effect of restenosis was determined by comparing arteries with and without restenosis. Progression/regression rates were not significantly different in angioplasty and non-angioplasty arteries. More new narrowings were identified in the angioplasty artery (p < 0.01). With regard to narrowings located in the angioplasty artery, progression was more common, regression less common, and the appearance of new narrowings more common in arteries with restenosis than in non-angioplasty arteries or arteries without restenosis. We believe that mechanical trauma to the artery during angioplasty could accelerate disease progression and the appearance of new narrowings in angioplasty arteries, whereas normalization of flow rate and pattern, especially in arteries without restenosis, attenuates the rate of progression and the appearance of new narrowings in these arteries. The final outcome depends on the balance between these factors.
Angioplasty, Balloon, Coronary↗
Comparison of early invasive and conservative treatments in patients with anterior wall non-Q-wave acute myocardial infarction.
To compare the long-term prognosis of a group of patients treated by an early invasive approach after a non-Q-wave anterior wall acute myocardial infarction (AMI) with a similar group treated conservatively, data from 110 consecutive patients with non-Q-wave AMI were retrospectively obtained from 3 different hospitals: (1) a hospital with coronary angioplasty and coronary bypass facilities favoring on early invasive approach, (2) a hospital with a catheterization laboratory and no coronary angioplasty or coronary bypass facilities, and (3) a community hospital without a catheterization laboratory. Patients were divided according to the presence or absence of an early invasive approach: those who had undergone in-hospital catheterization and revascularization (n = 55) and those with a conservative approach (n = 55). The early invasive approach resulted in a significant decrease in major events. The rate of recurrent myocardial infarction was 29% in the conservative group versus 7.2% in the invasive group (p = 0.025). Survival rate curves at 3-year follow-up showed significant differences in mortality (p = 0.001), recurrent myocardial infarction (p = 0.002), recurrent angina pectoris (p = 0.001), and development of congestive heart failure (p = 0.05). Multivariate analysis disclosed the early invasive approach to be an independent predictor for decreasing the likelihood of recurrent infarction by 86% (odds ratio 0.14, confidence intervals 0.04 to 0.48, p = 0.0006), and for decreasing the likelihood of recurrent angina by 66% (odds ratio 0.34, confidence intervals 0.18 to 0.63, p < 0.005). The early invasive strategy may result in an improved outcome in the treatment of patients with non-Q-wave anterior wall AMI compared with patients treated conservatively.
Aged↗
Transradial approach for coronary angiography and angioplasty.
The transradial approach has currently been advocated as an alternative catheterization method for coronary angiography and angioplasty, due to the recent miniaturization of angioplasty equipment. The purpose of this study was to assess the practical clinical applicability of this method. From June to November 1994, 100 patients underwent coronary angiography and angioplasty with the transradial approach. Their mean age was 66.6 +/- 11.2 years, and 79 were men. In 4, radial puncture was not successful, and in 3, femoral access was necessary to complete the procedure. Coronary angioplasty was performed in 63 patients (76 lesions) with angiographic success (per lesion) of 96%. In 5 patients, a stent was successfully implanted. All patients were ambulatory on the day after the angioplasty procedure. In 98% of the patients, the introducer was taken out 1 to 4 hours after the procedure by local compression using a special custom-made device. No patient required blood transfusion. Major complications occurred in 2 patients; both had a cerebrovascular accident (1 probably not procedure-related), and both recovered. A radial pulse was palpated in 91 of the patients before discharge, and in 6 others, adequate flow could be heard with Doppler. In 2 patients, radial flow was restored within several weeks. None of the patients suffered from ischemia of the hand. Two patients had a small pseudoaneurysm successfully treated by local compression. Thus, coronary angioplasty can be performed safely using the transradial approach with relatively few vascular complications and with better patient comfort. However, the procedure is more time-consuming initially compared with the transfemoral approach due to a learning curve regarding equipment selection and catheter manipulation.
Adult↗
One-stage coronary angiography and angioplasty.
The combination of diagnostic angiography and angioplasty as a single procedure is becoming common practice in many institutions, but the feasibility and safety of this strategy have not been reported. This report describes 2,069 patients who underwent coronary angioplasty over a 3-year period at an institution where combined angiography and angioplasty is the norm. All patients were prepared before angiography for potential immediate angioplasty. In 1,719 patients, angioplasty was performed immediately after the diagnostic angiogram, while separate procedures were performed in 350 patients. Of those 350 patients, 254 were referred for angioplasty after diagnostic angiography at other hospitals. One thousand one hundred ninety-seven patients were admitted electively for treatment of stable angina pectoris, and 872 underwent procedures during hospitalization for unstable angina or acute myocardial infarction. One thousand nine hundred seven patients (92.2%) had successful angioplasties; in 130 patients (6.3%) the lesion could not be dilated, but no complication occurred, and in 32 patients (1.5%) angioplasty ended with a major complication (0.8% death, 1.0% Q-wave myocardial infarction, 0.5% emergency coronary artery bypass surgery). There was no difference between the combined and staged groups with regard to success, major and minor complication rates or in length of hospitalization after angioplasty. We conclude that routine combined strategy for angiography and angioplasty is feasible, safe, easier for the patient, and more cost-effective than 2 separate procedures.
Angina Pectoris↗
Relation of thrombotic occlusion of coronary stents to the indication for stenting, stent size, and anticoagulation.
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Angioplasty, Balloon, Coronary↗
Retrieval of occluding unexpanded Palmaz-Schatz stent from a saphenous aorto-coronary vein graft.
The Palmaz-Schatz coronary stent is used frequently to reduce the rate of restenosis of balloon angioplasty in saphenous vein grafts. In many European centers, the stent, manually crimped on a balloon, is advanced across the stenosis without a protective sheath. This report describes a patient in whom an attempt to deploy a stent in the orifice of a saphenous vein graft was complicated by dislodgement of the unexpanded stent from the balloon. The unexpanded stent caused immediate occlusion of the vein graft and severe ischemic symptoms. The stent was retrieved by inflation of another balloon in the graft, distal to the stent, pulling the balloon toward the guiding catheter, and then withdrawing the whole system.
Aged↗
Emergency rotational ablation of a calcified left main coronary artery stenosis in a patient with ischemic induced cardiogenic shock.
High-speed rotational ablation is ideal in the treatment of chronic calcified atherosclerotic lesions. This report describes an elderly woman with a prior history of coronary artery bypass surgery, who developed cardiogenic shock secondary to occlusion of a saphenous vein graft to the obtuse marginal branch of the circumflex coronary artery. Her left main coronary artery was heavily calcified and almost completely occluded. She was treated successfully by high-speed rotational ablation of her left main stenosis.
Aged↗
Myocardial ischemia induced by topical use of 5-fluorouracil.
An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.
Administration, Topical↗
Acute myocardial infarction--the angiographic picture: new insights into the pathogenesis of myocardial infarction.
The angiographic appearance of the coronary arteries were examined in 302 patients with stable angina pectoris and compared to 308 patients with acute myocardial infarction, who received high-dose intravenous thrombolytic therapy, in order to elucidate the underlying angiopathological picture in the two diseases. In each group coronary lesions were present in proximal segments of the arteries and were closely related to bifurcations. Lesions were more extensively distributed in the coronary tree in patients with stable angina and they had an average of 5.4 lesions per patient, compared to the acute myocardial infarction group who had only 2.4 lesions. Also, in the acute myocardial infarction patients, four-fifths of the culprit arteries were patent, 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque and in 190 (62%) the lesions were eccentric. The study shows that patients with myocardial infarction who are suitable for thrombolysis have a unique coronary angiographic picture and the acute episode is caused by sudden rupture of a localized atheromatous plaque which initiates an obstructive thrombotic cascade.
Angina Pectoris↗
Early intravenous thrombolysis in acute myocardial infarction: the Jerusalem experience.
Myocardial damage in acute myocardial infarction is a time-dependent process. We examined the influence of very early thrombolytic therapy, comparing prehospital to hospital administration, in a consecutive group of patients with myocardial infarction on mortality, complications and the preservation of left ventricular function. Seven hundred sixty patients received early thrombolytic therapy: 114 at home (time delay to treatment 1.4 +/- 0.8 h) and 646 in hospital (2.1 +/- 1.0 h). Sixteen patients died in hospital and significant hemorrhage occurred in 15 (including three patients with hemorrhagic stroke). There was no difference between groups in hospital mortality or rate of complications. The duration of ischemia was shorter in patients with prehospital therapy (pain duration: 3.3 +/- 2.1 vs. 4.0 +/- 2.2; P < 0.05, and time to recovery of the ST segment in the electrocardiogram: 4.3 +/- 3.3 vs. 6.6 +/- 6.3; P < 0.002). Peak plasma creatine kinase was earlier in patients with prehospital therapy (11.2 +/- 5.0 vs. 13.0 +/- 5.8; P < 0.002), although there was no difference between groups in the absolute peak plasma level. Left ventricular function was assessed by contrast ventriculography 1 week after admission (616 patients). Ventricular function was better in patients with prehospital therapy: (ejection fraction of 58 +/- 13% vs. 54 +/- 15%; P < 0.05 and a left ventricular dysfunction index of 534 +/- 515 vs. 691 +/- 519 units; P < 0.05). We conclude that prehospital thrombolytic therapy is feasible and safe. Reperfusion is achieved earlier and more myocardium can be salvaged using this strategy without increasing the rate of complications.
Coronary Angiography↗
Reuse of balloon catheters for coronary angioplasty.
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Angioplasty, Balloon, Coronary↗
Thrombolysis in the era of the randomized trials.
Thrombolytic therapy in acute myocardial infarction is of established value in recanalizing the occluded coronary artery, reducing infarct size, and decreasing mortality. Here, we review the extensive information provided by large clinical trials on agent and patient selection, timing of treatment, adjuvant therapies, and complications. Early treatment is of prime importance. Tissue plasminogen activator is slightly superior to streptokinase, especially in young patients treated early. Intravenous heparin should be used in conjunction with tissue plasminogen activator, although its role when streptokinase is used is less clear. Aspirin, beta-blockers, and converting enzyme inhibitors are of proven value as adjunctive therapies; nitrates and magnesium are not. Newer antithrombotic and antiplatelet agents (eg, hirudin and glycoprotein IIb/IIIa receptor antagonists) may further improve results.
Combined Modality Therapy↗
Combined mechanical and thrombolytic treatment for totally occluded bypass grafts.
Totally occluded venous grafts are usually less amenable to mechanical reperfusion alone (for example percutaneous transluminal coronary angioplasty, PTCA) because of the large mass of thrombotic material within the graft. A combined approach using mechanical and thrombolytic treatment might therefore be more successful. Twenty one patients (20 males, one female) with a mean age of 64.5 (SD 5.6) years underwent angiography because of crescendo or unstable angina (n = 19) or myocardial infarction (n = 2) at a mean of 21.7 (18.6) days after onset of symptoms (range 1-60). All patients had had coronary artery bypass grafting (CABG) at a mean of 8.02 (4.02) years (range 0.3-13 years) before the current admission. At catheterisation, totally occluded venous bypass grafts to the left anterior descending coronary artery or diagonal (n = 10), marginal (n = 6), or right coronary artery (n = 5) were found. A combination of PTCA and thrombolytic treatment (in eight patients extended thrombolysis for 24 hours) was successful in reopening the venous graft in 16/21 patients (76.2%). Immediate complications included femoral haematoma (4), distal embolisation (3), and infection in one patient. Out of 13 patients catheterised within three months, two had reoccluded, seven had restenosis, while four had patent grafts. Recurrent PTCA (at least once more) was done in eight patients. At long term follow up of a mean of 26.7 (21.6) months (range 4-75 months), four patients were asymptomatic, eight still suffered from mild stable angina, while three had recurrent hospital admissions and needed a second coronary artery bypass. A combination of thrombolytic treatment and PTCA is a feasible and practised approach to recanalise recently occluded venous bypass grafts.
Aged↗
The effect of overdrive pacing rate and duration on ventricular escape rhythms in patients with chronic complete atrioventricular block.
The effect of overdrive (OD) pacing rate and duration on subsidiary pacemakers was evaluated in 54 patients with third-degree AV block. They had a permanent pacemaker implanted 61 +/- 56 months earlier because of complete AV block in 38 patients and, in 16 patients because of second-degree AV block, which in the interim advanced to complete AV block. The patients had a reliable infranodal escape rhythm, with a mean cycle length of 2,022 +/- 603 msec, upon discontinuation of the ventricular OD pacing, at a rate of 40 beats/min. The escape interval and escape rhythm cycle length was evaluated after OD pacing at 40, 50, 60, 70, 90, and 100 beats/min for 30 seconds, at each rate. In 100% of the patients the subsidiary pacemaker recovered after OD pacing at 40 and 50 beats/min and the number decreased to 59% at a rate of 100 beats/min. The escape interval prolonged gradually between OD pacing at 40 and 100 beats/min, by 56%. The effect of OD pacing duration at 50 and 70 beats/min was evaluated. At an OD pacing rate of 70 beats/min there was a significant effect of the pacing duration on the escape interval. There were significant differences in the escape interval duration and escape rhythm cycle length between males and females, patients with or without coronary artery disease, and patients with narrow or wide QRS escape. However, the increase in the OD pacing rate had a similar effect on the escape interval in the above mentioned groups. There was no effect on the paced QRS duration and sinus cycle length at each OD pacing rate.(ABSTRACT TRUNCATED AT 250 WORDS)
Aged↗
Silent myocardial ischemia during exercise testing: does it indicate a different angiographic and prognostic syndrome?
The prognostic significance of silent myocardial ischemia detected during graded exercise testing (GXT) is uncertain. The angiographic characteristics and long-term follow-up of 83 patients with silent ischemia (group 1), mean age 58 +/- 9 years, were compared with 83 age- and sex-matched patients with typical angina pectoris (group 2). Basic characteristics and mean follow-up (42 +/- 22 months) were similar in both groups. Patients with silent ischemia were characterized by longer duration of exercise test (6.5 vs. 4.8 min, p < 0.01), larger extent of maximum ST depression during peak exercise (2.4 vs. 2.0 mm, p < 0.01) and higher maximal double product at peak exercise (24,650 vs. 20,825, p < 0.01) compared to group 2. Long-term follow-up revealed similar rates of mortality (3.6 vs. 4.8%, p = NS) and major cardiac events (19.3 vs. 21.7%, p = NS). However, patients with typical angina tended to have more revascularization procedures (81 vs. 61%, p < 0.1). Thus, patients with silent ischemia have a better GXT capacity compared to patients with typical angina pectoris. Despite a similar severity of coronary involvement, patients with typical angina pectoris tend to have more revascularization procedures, yet the long-term prognosis appears similar.
Angina Pectoris↗
Value of dobutamine/nitrate radionuclide angiography in predicting revascularization effects on ventricular function.
OBJECTIVE: Dobutamine and Nitrate Radionuclide Angiography (RNA) may help to distinguish viable from nonviable myocardium and to predict revascularization effects on LV function. SETTING: Ambulatory. EXPERIMENTAL DESIGN: Prospective. PATIENTS AND METHODS: We studied 12 patients (11 male, 1 female; mean age 56 +/- 10 years) with three-vessel disease, severe LV dysfunction, and prior MI for a mean follow-up time of 10 +/- 3.4 months. Thallium-201 scintigraphy favored potential viability in all patients: inducible ischemia with satisfactory perfusion in more than one coronary arterial territory. Global and regional LVEF's were calculated from preoperative RNA (baseline rest study and with continuous dobutamine infusion with gradual rate increase plus oral nitrates) and postoperative RNA at 1 and 6 months. RESULTS: There was no operative mortality, but two late deaths occurred. Symptomatically, most patients showed improvement. Global LVEF increased during dobutamine and nitrates preoperatively (p < 0.01), but not at 1 and 6 months postoperatively (without pharmacological intervention). Mean LVED volume was not significantly changed postoperatively. Regional EF improvement was found in 4 out of 9 LV wall segments under dobutamine and nitrates, and this increase persisted postoperatively at 1 and 6 months. CONCLUSIONS: Mild but significant increase in global LVEF during dobutamine and nitrates administration is not predictive of postoperative LVEF improvement. However, regional EF improvement appears to be predictive of post-revascularization LV functional improvement.
Administration, Sublingual↗
Single physician approach to radiofrequency catheter ablation in patients with supraventricular tachycardia.
The minimal requirements for safe and effective performance of catheter ablation using radiofrequency current are still unclear. To determine the feasibility and safety of single physician approach to catheter ablation of supraventricular tachycardia substrate using radiofrequency energy, the results of the ablation procedure in 52 consecutive patients were evaluated. The procedures were performed during 1 year by the same physician and nurse. Twenty-one patients had selective atrioventricular (AV) nodal pathway ablation and 31 patients had accessory AV pathway ablation. Forty-eight patients (89%) had the diagnostic and the ablative procedure during the same electrophysiological test. In the 21 patients with AV nodal reentrant tachycardia, all had successful selective ablation of the fast (13) or the slow (8) pathways. Eight patients had recurrence of the clinical tachycardia and had a successful reablation. No patient developed complete AV block or other significant complications. The mean fluoroscopy time during the procedure was 16.0 +/- 8.6 minutes. In the eight patients with Wolff-Parkinson-White syndrome, all concealed accessory pathways were successfully ablated with a mean fluoroscopy time of 30.0 +/- 27.9 minutes. Two patients had recurrence of the conduction through the accessory pathway and had a successful reablation. Eighteen of 19 patients with a single overt accessory pathway had successful ablation, with a fluoroscopy time of 22.7 +/- 20.6 minutes. Three patients had an early recurrence of the conduction through the accessory pathway, reablation was successful in two of them. Ten accessory pathways were ablated in four patients with multiple pathways during nine procedures. Only two patients developed minor peripheral vascular complications.(ABSTRACT TRUNCATED AT 250 WORDS)
Adult↗