Biomedical subjects

M S Fahim

Publications and source records attributed to M S Fahim.

11 recordsLinked to original sources

PubMed1979

Local male hormonal therapy in male infertility: a preliminary report.

The therapeutic effect of local infiltration of the testis by testosterone crystalline suspension was studied in 18 cases of severe oligozoospermia. Evaluation was done by semen analysis follow-up, and results were correlated with preoperative testicular biopsies. About 40% of the cases showed improvement of sperm count and/or motility. Testicular biopsies of responding cases showed mild inhibitory changes, such as sloughing or partial spermatogenic arrest at late stages, while cases with tubular hyalinization or spermatogenic arrest at the stage of spermatogonia showed no response. The method proved to be simple, safe, and promising.

Adult↗

PubMed1978

Effect of ultrasound on testicular electrolytes (sodium and potassium).

The testes of 50 rats were placed in a cup filled with water and received 1 W/cm2 of ultrasound for 15 min. Fluid was collected from the seminiferous tubules and rete testis of the treated and control groups at 1, 8, 12, and 24 hr intervals. Ultrasound increased the sodium concentration in the fluid of the seminiferous tubules, decreased the sodium concentration in the fluid of the rete testis, increased the potassium concentration in the fluid of the rete testis, and decreased the potassium concentration in the fluid of the seminiferous tubules. Fourteen, slightly sedated, monkeys (Macaca fascicularis) were treated with 1/2 W/cm2 of ultrasound for 30 min. Water was used as the coupling agent for seven monkeys and 3% NaCl was used as the coupling agent for the other seven monkeys. The efficacy of ultrasound treatment in reducing sperm count to zero and achieving zero motility was increased when 3% NaCl was used. Sperm count was at the level of presonication after 20 weeks when water was used as a coupling agent.

Animals↗

PubMed1977

Multiple odontomas.

Explore the source record for details and available documents.

Abnormalities, Multiple↗

PubMed1977

Ultrasound as a new method of male contraception.

Twenty male cats were treated once or twice with 1 watt/sq cm of ultrasound for 10 minutes. Each of 24 male dogs received one to three treatments with 1 watt/sq cm for 10 minutes. Another six dogs were treated with 2 watts/sq cm for 15 minutes. Four Cebus apella monkeys were treated with the same dosage as that used for the cats and dogs. A dosage of 1 watt/sq cm for 10 minutes was also applied to four human patients without the use of anesthetics, and no pain or side effects were noted. In all treated animals as well as in human patients the results indicate that ultrasound significantly suppresses spermatogenesis according to the dosage and frequency of treatment, without any effect on Leydig cells or blood testosterone levels.

Animals↗

PubMed1977

Effects of sonication on mature rat testes.

Exposure of rat testes to high-frequency sound waves temporarily interrupted the spermatogenic process. Rats treated with 1 watt/sq cm for 10 minutes exhibited a degeneration of advanced germinal cells and were incapable of impregnating females for 150 days. Forty-eight hours after sonication, spermatocytes and spermatids developed irregular membranes and released their contents into theinterstitium. Spermatogonia, Sertoli cells, and Leydig cells appeared normal, and no genetic anomalies could be detected in the progeny of treated animals. It was hypothesized that the reduction in sperm count was due to changes in membrane permeability which produced conditions unfavorable to maturation of testicular cells.

Animals↗

PubMed1976

Effects of subtoxic lead levels on pregnant women in the state of Missouri.

Cords, placentas, placental membranes, and maternal and fetal blood were collected from 249 women delivered in Columbia, Missouri (Region I). The same samples were obtained from 253 women delivered in Rolla, Missouri (Region II), near lead mining areas. The incidence of term pregnancies with early membrane rupture was 0.41% in Region I and 17% in Region II. The incidence of premature deliveries was 3% and 13.04% respectively. Lead concentration in blood and placental tissues of term pregnancies revealed no significant changes. In term with early membrane rupture, blood concentration of lead was higher, as was the case in placental tissues and cord. Lead concentration was highest in membrane tissues, in mug/100 grams (Regions I and II respectively): placenta, 6.0 +/- 0.01 and 7.0 +/- 0.03; cord, 11.0 +/- 0.34 and 12.0 +/- 0.18; membrane, 38.9 +/- 2.64 and 45.3 +/- 3.12. A high positive correlation (r = 0.2941) between lead concentration in maternal and fetal blood existed. Both were significantly (P less than 0.01) higher in preterm pregnancies and early membrane ruptures than in term pregnancies. These data suggest that subtoxic levels of lead could increase the incidence of early membrane rupture and premature deliveries.

Ceruloplasmin↗

PubMed1975