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Biomedical subjects

M S Cox

Publications and source records attributed to M S Cox.

29 records · Page 2Linked to original sources

Silicone oil for advanced proliferative vitreoretinopathy.

Repeated vitreous microsurgery followed by silicone oil injection was performed on a consecutive series of 51 patients with retinal detachment and advanced proliferative vitreoretinopathy who were not cured by previous conventional management, including vitrectomy, membrane peeling, gas tamponade, and scleral buckling. Anatomic reattachment was achieved in 65% of these cases. Ambulatory or better vision was restored in 74% of the anatomically successful cases. The silicone oil was removed from 30% of the eyes with complete attachment of the retina posterior to the buckle.

Adolescent↗

Removal of epimacular membranes.

Vitreous surgery was used to remove epiretinal macular membranes in 328 cases, 184 (56%) of which had membranes that were considered idiopathic and 144 (44%) which were due to other causes. The 12- to 92-month follow-up showed that visual acuity improved two lines or more in 243 (74%) of the eyes, 79 (24%) were unchanged and 6 (2%) became worse. Recurrence of membranes was seen in 24 (7.3%) eyes and 27 (8%) eyes developed complications. In the idiopathic cases visual results were significantly better and complications fewer. Rapidly progressive nuclear sclerosis was noted in 23 (12.5%) eyes. The degree of cystoid edema had no relationship to the final visual result. Pseudoholes which were present in 14 (8%) of the idiopathic cases either became smaller or disappeared following successful surgery with an average increase in acuity of five lines.

Adolescent↗

Outpatient regulation of the insulin-requiring person with diabetes (an alternative to hospitalization).

One hundred and six insulin-requiring diabetic patients were randomly recruited to a pilot out-patient diabetes regulation and self-care program. The program was designed to offer an alternative to hospitalization. 89 patients completed the 5-day program. Fasting plasma glucose values at 5 days were significantly lower than initial levels (263 +/- 73 mg/dl vs 156 +/- 60 mg/dl; p-value less than 0.001). Long-term diabetic control was similarly improved at 6 months after entry when total glycosylated hemoglobin levels were significantly lower than initial values (13.8 +/- 2.8% vs 11.1 +/- 2.4%; p-value less than 0.0005). 17 patients failed to complete the program. Only four patients of the 89 were subsequently hospitalized with diabetes-related conditions. 445 hospital days were saved during the study period with calculated total dollar savings over $90,000. It is suggested that a structured out-patient program for diabetes regulation and self-care can be successfully developed and carried out at a significantly lower cost than hospitalization. Third party payors should take cognizance of these programs and appropriately include them in their health care coverage.

Adult↗

Retinal detachment due to ocular penetration. I. Clinical characteristics and surgical results.

The records of 74 patients--young and almost exclusively males--with retinal detachment due to ocular penetration were reviewed to study the characteristics and surgical results of this type of traumatic retinal detachment. There was a high incidence of industrial and domestic accidents. The incidence and degree of myopia were significantly lower than in nontraumatic cases of retinal detachment. The time interval between the injury and the detection of the retinal detachment was variable. Many of the eyes with longer latent intervals had classic signs of traumatic retinal detachment. The most common type of retinal break was a dialysis in the oral zone at the posterior vitreous base border. The most common cause of these retinal breaks was severe traction from contracting vitreous bands and membranes that followed the loss of vitreous gel from the eye. Surgical results were relatively poor; recurrence was common because of progressive vitreous pathology. Postoperative traction on the vitreous base by the continued shrinkage of vitreous membranes was noted in 50% of the eyes that contained such membranes preoperatively.

Adolescent↗

Treatment of intravitreal and prepapillary neovascularization following branch retinal vein occlusion.

Ten eyes which had developed retinitis proliferans following branch retinal vein occlusion were treated with xenon photocoagulation utilizing an ablative technique limited to the effected retinal quadrants. In eight of the ten eyes, complete regression of the vessels was obtained, as evidenced by nonfilling on subsequent fluorescein angiography. The remaining two eyes showed significant but incomplete closure. There were no postoperative vitreous hemorrhages, no significant permanent complications, and the visual acuity remained at or better than pretreatment levels in all cases. In conclusion, we wish to reemphasize the limited scope of this report. The series, though consecutive, is small and the follow-up period relatively short. On the basis of the cases presented here, we believe that continued investigation using this mode of treatment is warranted, and that this method may prove to be of significant value in the management of complicated retinal branch vein occlusion.

Adult↗