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Biomedical subjects

M S Arayne

Publications and source records attributed to M S Arayne.

18 recordsLinked to original sources
PubMed2001

Cefuroxime antacid interactions.

Cefuroxime sodium a second generation semi-synthetic cephalosporin is effective for treating meningitis, lower respiratory tract infections, gonorrhea, bone and joint infections and is approved for surgical prophylaxis. There are number of synergistic and as well as antagonistic drug interactions reported for this antibiotic. Withstanding to gastric irritations caused by this antibiotic, antacids may possibly be co-administered with cefuroxime, which may result in severe adverse drug interaction. The present work describes the effect of magnesium carbonate, magnesium hydroxide, magnesium trisilicate, megaldrate powder, sodium bicarbonate, aluminum oxide and simethicone suspension on the in vitro availability of cefuroxime sodium. The mechanism of interaction between antibiotic and antacids was also studied.

Journal Article↗
PubMed2001

In vitro activity of ceftizoxime and ceftazidime in presence of essential and trace elements.

The research work comprises of the study of the changes in antimicrobial activity of ceftizoxime and ceftazidime after interaction with essential and trace elements. The minimum inhibitory concentration (MIC) was observed and thereafter compared with the standard MIC's of the respective drug by agar dilution method against both Gram positive and Gram-negative organisms so as to evaluate changes in antimicrobiological activity of the standard cephalosporins after metal interactions. It was observed that these metal elements that are essential for our body, either present within the body or coadminstered with vitamins markedly influence the MIC's of antibiotics by producing synergism or antagonism.

Journal Article↗
PubMed1999

Gliclazide.

The crystal structure of gliclazide, N-[(perhydrocyclopenta [c]pyrrol-2-yl)aminocarbonyl]-p-toluenesulfonamide, C15H21B3O3S, a second-generation oral hypoglycemic agent, contains discrete molecules with normal molecular dimensions. Both of the five-membered fused rings adopt envelope conformations. The molecules are linked into chains by intermolecular hydrogen bonds involving amino-H atoms, with N...O separations of 2.967 (3) and 2.949 (3) A.

Crystallography, X-Ray↗
PubMed1993

Erythromycin-antacid interaction.

The in vitro release of erythromycin stearate in the presence of aluminium hydroxide, aluminium trisilicate, magnesium oxide, magnesium trisilicate, sodium hydrogen carbonate and a combination of aluminium hydroxide gel, magnesium hydroxide and dimethyl polysiloxane has been studied by the USP XX dissolution method. The dissolution of erythromycin was found to be markedly retarded in the presence of all the antacids studied except sodium hydrogen carbonate. An attempt was made to elucidate the mechanism of this effect.

Antacids↗
PubMed1977

Effect of environments on human functions: studies on water metabolism.

The purpose of this review is to study general behaviour of human systems with respect to the environmental conditions. This type of work will be of profound significance to record the effect of medical treatment in various climatic zones of the world (Arayne and Saify, 1975). We attempted to discuss various facts which would be helpful for tackling the health problems of the people residing in these areas. The statistical data is avoided at the moment and a descriptive pattern is adapted in order to express views, about one of the important aspects of medical science.

Adaptation, Physiological↗