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Biomedical subjects

M S Allen

Publications and source records attributed to M S Allen.

168 records · Page 10Linked to original sources
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Pulmonary toxicity of methyl methacrylate vapors: an environmental study.

The toxicity of methyl methacrylate vapors was tested using a mouse model. Mice were exposed for prolonged periods (2 hr twice daily for 10 days) to high doses (1,500 ppm) under atmospheric oxygen and carbon dioxide concentrations. Histologic examination of the lungs, liver, heart, and kidney showed no evidence of damage.

Animals↗
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Haemophilus influenzae septic arthritis in adults.

The incidence of Haemophilus influenzae infections appears to be increasing although disease in adults due to this organism remains unusual. Only 16 cases of septic arthritis caused by this agent were found in a review of the literature. Two additional cases are reported and a summary of the clinical characteristics of these patients is presented. In general, females are affected more commonly than males, and blacks more often than whites. Joint involvement may be single or multiple, and associated or underlying conditions are frequent. Treatment with a variety of antimicrobials was generally successful and 87% of the infected joints was restored to pre-infection status. There were no specific characteristics in the clinical presentation which would allow an early precise etiologic diagnosis.

Adult↗
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Effectiveness of screening aqueous contrast swallow in detecting clinically significant anastomotic leaks after esophagectomy.

BACKGROUND: Aqueous contrast swallow study is recommended as a screening procedure for the evaluation of esophageal anastomotic integrity following esophagectomy. The aim of this study was to assess the accuracy of water-soluble contrast swallow screening as a predictor of clinically significant anastomotic leak in patients with esophagectomy. PATIENTS AND METHODS: The records of 505 consecutive patients undergoing esophagectomy in Mayo Clinic from January 1991 through December 1995 were retrospectively reviewed. 464 (92%) patients had water-soluble contrast swallows performed in the early postoperative period (median postoperative day 7, range 4-11 days). RESULTS: A total of 39 radiological leaks were obtained but only 17 of these had clinical signs of anastomotic leakage. Furthermore, 25 patients who had normal swallow study developed a clinical anastomotic leak. There were therefore 22 (4.7%) false positive and 25 (5.4%) false negative results giving values for the specificity, sensitivity and false negative error rate of the radiological examination of 94.7, 40.4, and 59.5% respectively. Aspiration of the contrast agent was noted on fluoroscopy in 30 (6.5%) patients. Only 2 (0.4%) patients developed aqueous contrast agent-caused aspiration pneumonia. There was no procedure-related mortality. CONCLUSION: While radiological assessment of esophageal anastomoses in the early postoperative period using aqueous contrast agents appears to be a relatively safe procedure, the poor sensitivity and high false negative error rate of this technique, when performed on postoperative day 7 and in a series with clinical anastomotic leak rate of 9%, is insufficient for it to be worthwhile as a screening procedure.

Adolescent↗