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Biomedical subjects

M Rutter

Publications and source records attributed to M Rutter.

At least 163 records · Page 9Linked to original sources
PubMed1989

Mothers' speech to autistic children: a preliminary causal analysis.

Changes over time in the language patterns of autistic children and their parents were examined during the course of a home-based intervention programme. Although the language used by parents to their autistic children was not deficient, language modification procedures were found to lead to rapid changes in the verbal interaction between parents and children. Parents in the non-intervention, control group showed little change in their communication style. In the experimental group, but not in the control group, a close relationship was found between increases in the use of language-eliciting utterances by their mothers and improvements in children's socialized language. The pattern of association between parent and child language suggested that the main effect was of the parent on the child but that the extent of the child's language handicap constrained what could be achieved by treatment.

Autistic Disorder↗
PubMed1989

Recognition and expression of emotional cues by autistic and normal adults.

High-functioning autistic adults were compared with normal adults using a battery of tests devised to assess the recognition and expression of emotional cues in both facial and vocal modalities. The autistic subjects were relatively impaired in both the appreciation and production of emotional expressions. Although no one test provided a clear-cut separation of the groups at the individual level, composite scores did separate the groups quite well. It is suggested that this battery of tasks may have some value in family genetic studies of autism that need to identify subclinical deficits that might be aetiologically linked with autism.

Adult↗
PubMed1989

Pathways from childhood to adult life.

Principles and concepts of development are reviewed in relation to life-span issues noting the need to consider: development in its social context; timing of experiences; intrinsic and experiential factors; continuities and discontinuities; parallels and differences between normal and abnormal development; heterotypic and homotypic continuities; key life transitions; risk and protective factors; indirect chain affects; mediating mechanisms; age as an index of maturational and experiential factors. Developmental findings from childhood to adult longitudinal studies are reviewed for possible mediating factors. These include: genetic mechanisms; the (non-genetic) biological substrate; shaping of the environment; cognitive and social skills; self-esteem and self-efficacy; habits, cognitive sets and coping styles; links between experiences.

Adolescent↗
PubMed1989

Adult personality functioning assessment (APFA). An investigator-based standardised interview.

The development of an investigator-based standardised interview to assess patterns of specific and general social dysfunction is described. It covers six domains of functioning: work; love relationships; friendships; non-intimate social contacts; negotiations; and everyday coping. Inter-rater reliability was tested by three investigators rating 21 audiotaped interviews, and was shown to be high, with an intraclass correlation of 0.87 for the total score. The pattern of associations between specific and general social dysfunction was examined through determination of sensitivities and specificities and through LISREL modelling. The findings varied across social domains but it was concluded that the total APFA score provided a reasonable measure of general social dysfunction.

Adaptation, Psychological↗
PubMed1988

Epidemiological approaches to developmental psychopathology.

Developmental psychopathology as a research approach draws on both developmental and psychopathologic perspectives to tackle questions about causal mechanisms. Developmental perspectives are discussed in terms of the implications that flow from age differences in prevalence, age trends in remission of disorders, developmental appropriateness of psychiatric conditions, continuities and discontinuities in psychopathology between childhood and adult life, and age differences in the effects of psychiatric risk factors. Psychopathologic perspectives are considered in terms of continuities and discontinuities between normality and pathology and the contrasts between pervasive and situation-specific disorders, and by the differences between single variables and behavioral composites. The use of epidemiological data to examine causal processes is discussed, with attention to the need to consider development in its social context and to examine indirect, as well as direct, causal chains of connection.

Aging↗
PubMed1988

Infantile autism and urinary excretion of peptides and protein-associated peptide complexes.

Sixty-nine early morning urine samples obtained from three groups of young adult males (autistic, mentally handicapped, and a group of men of normal intelligence) were analyzed using the methods described by Trygstad et al. (1980). No consistent patterns of urinary chromatographic profiles were identified. A number of possible contributing factors are discussed in relation to this failure to replicate the results of previous studies.

Adult↗
PubMed1988

Selective subcortical abnormalities in autism.

Nine physically healthy, adult autistic men, with normal or near normal intelligence, and 13 healthy male controls were examined in a CT brain scan study. CT scans were analysed with a fully automated computer-assisted program, and regional brain radiodensities were measured with careful attention to artefacts. Autistic patients revealed significantly larger third, but not lateral, ventricular size and significantly lower mean caudate, but equivalent mean frontal and thalamic, radiodensities compared to controls. The sizes of the Sylvian fissures and interhemispheric fissure were equivalent between groups. The findings are consistent with selective subcortical abnormalities in autism.

Adult↗
PubMed1988

The assessment of lifetime psychopathology: a comparison of two interviewing styles.

A structured respondent-based version of the SADS-L interview was compared with a semi-structured investigator-based version of the same interview in terms of efficiency in assessing lifetime psychopathology. There was substantial agreement across most Research Diagnostic Criteria (RDC) categories, but there was less agreement on the rating of symptoms. The implications of these similarities and differences between the techniques are discussed.

Adult↗
PubMed1988

Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults.

Regional cerebral blood flow, oxygen consumption and glucose consumption were measured by positron emission tomography in six young autistic men. No significant differences were found between patients and normal controls for any of the physiological variables. The results do not substantiate the previous finding of glucose hypermetabolism in autism; the likely reasons for the variance in findings are discussed.

Adult↗
PubMed1988

Psychiatric interviewing techniques. A second experimental study: eliciting feelings.

The effects of two experimental interview styles, designed to differ in the extent of their use of active feeling-oriented techniques but similar in their use of active fact-oriented techniques, were compared in initial diagnostic interviews with the mothers of children referred to a psychiatric clinic. The style that employed a higher level of actively responsive feeling-oriented techniques elicited more emotional expression and more often obtained certain feelings of potential diagnostic significance. The actively responsive style was more effective in increasing the amount of feeling expressed if mothers' spontaneous rate of expression was relatively low.

Adolescent↗
PubMed1987

Autism and pervasive developmental disorders: concepts and diagnostic issues.

The purpose of this report is to bring up to date available information on the defining features and diagnostic issues relating to autism and related disorders. We review the validity of the syndrome based on our last review (Rutter, 1978; Schopler, 1978). Subsequent data have produced refinement in our understanding of both diagnostic criteria and the nature of the basic deficit. Controversies over both the boundaries and the heterogeneity within the autism syndrome are evaluated according to available evidence. Diagnostic rating instruments for expediting systematic sample selection are critiqued, and leads for new research directions are suggested.

Autistic Disorder↗
PubMed1987

Which boys respond to stimulant medication? A controlled trial of methylphenidate in boys with disruptive behaviour.

Thirty-eight boys, referred for psychiatric treatment because of serious problems of behaviour, underwent a double-blind, placebo-controlled, crossover trial of methylphenidate and placebo. Methylphenidate was an effective treatment over a 3-week period. A good response to methylphenidate was predicted by higher levels of inattentive and restless behaviour, impaired performance on tests of attention, clumsiness, younger age and by the absence of symptoms of overt emotional disorder. DSM-III and ICD-9 diagnoses of 'hyperactivity' were not good predictors. The results support the validity of a construct of hyperactivity in describing childhood psychopathology, but emphasize the need for a refinement of diagnostic criteria.

Attention↗
PubMed1987

The effect of intravenous frusemide on urine dopamine in normal volunteers: studies with indomethacin and carbidopa.

1. The urine dopamine response to intravenous frusemide (30 mg) was investigated in 15 salt replete male volunteers. The effects of oral indomethacin (100 mg) and oral carbidopa (100 mg) given before intravenous frusemide were studied in the same group of subjects. 2. Frusemide produced a significant increase in urine dopamine output within 15 min. 3. Indomethacin attenuated the natriuretic and renin responses to frusemide, but did not alter urine dopamine output. 4. Carbidopa lowered urine dopamine to undetectable levels, but did not significantly affect the natriuretic and renin responses to frusemide. 5. We conclude that urine dopamine excretion after frusemide is not directly related to increased sodium excretion or renin response and it is not mediated by the prostaglandins. In addition, dopamine does not contribute to the renal actions of frusemide under normal conditions.

Administration, Oral↗
PubMed1987

The role of cognition in child development and disorder.

The role of cognition in child development is reviewed with respect to the role of cognitive processing and cognitive deficits. Cognitive processing is discussed with respect to the self-system; the effects of psychosocial experiences; risk, vulnerability and protective mechanisms; vulnerability to depression; aetiology and treatment of depression. Cognitive deficits are discussed with respect to the socio-emotional consequences of language delay and reading difficulties; hyperkinetic/attentional deficit syndromes; schizophrenia; and autism. It is concluded that the ways in which we appraise our life circumstances and the ways in which we react to experiences of all kinds are greatly influenced by how we think about ourselves and our environment. Biases and distortions in such cognitive processing may be associated with social and emotional malfunction. These biases may derive from earlier experiences, from intensive temperamental styles, or from deficits in the ability to process incoming information. The further study of cognitive processing and cognitive deficits is likely to be rewarding and helpful for clinical practice.

Attention Deficit Disorder with Hyperactivity↗