[The effect of air pollution on respiratory disease in children].
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Biomedical subjects
Publications and source records attributed to M Rutishauser.
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Apart from cigarette smoking and air pollution, lower respiratory tract infections of viral origin in early childhood are considered to be one of the risk factors for chronic obstructive lung disease. Acute bronchiolitis accounts for the typical disease of the small airways in the first two years of life. 16 symptom-free former patients have been studied 16 to 22 years after an acute attack of bronchiolitis. A complete lung function test was performed with special regard to the small airways. The volume of Isoflow proved to be the most sensitive test. The changes found are considered to be mild. Follow-up will show whether they correlate with an as yet symptom-free stage of a chronic obstructive lung disease.
Three children had signs of illness for 5 to 18 months before tuberculosis was diagnosed, in spite of tuberculin conversion and abnormal chest X-ray findings in two. One 15-year-old boy developed tuberculous pericarditis, a 17-year-old boy had spondylitis, and a 10-year-old boy middle lobe pneumonia. The aim of this presentation is to emphasize that tuberculosis, although now rare in childhood, still exists. Prevention and early diagnosis are also discussed.
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In a 4-day-old baby a unique form of interrupted aortic arch was diagnosed, where the interruption was located between the right carotid and the right subclavian arteries in a right descending aorta. The additional large ductus was ligated, the VSD was palliated with pulmonary arterial banding. For the repair of the interrupted aortic arch with its long distance between the ascending and descending portions and the complicating proximity of the superior vena cava, a long pliable material had to be used. The anastomosis was successfully performed with a bovine arterial heterograft.
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To assess small airway obstruction in teenagers with a habit of smoking maximal expiratory flow-volume where obtained while the children were breathing first air and then a helium-air-mixture. The point of identical flow (PIF), the volume in which flow was the same with air and with helium was for the smokers significantly higher than the mean PIF in the nonsmokers-controls.
Primary hypoventilation (Ondine's curse), due to diminished sensitivity ofthe respiratory center to CO2, is very rare. Up to now only a few patients have been observed, ten of whom were children. Familial occurrence was reported in 1976 for the first time. The cases are described of a 10-year-old girl and her mother who both showed the typical clinical and pathophysiological symptoms. Our own observation also suggests that this unknown defect of respiratory regulation could be inherited. Sedation, anesthesia, or severe respiratory tract infection are life-threatening situations in these patients. Pulmonary hypertension and right heart failure are possible long-term complications.
Aneurysm of the nonpatent ductus arteriosus in the newborn is a rare, but potentially fatal condition. Of reported ductal aneurysm up to 1969, diagnosis was made at autopsy only. We report here to our knowledge for the first time on a two week old infant with correct preoperative angiographic diagnosis followed by a successful surgical cure.
53 spine fusions using Harrington's method were performed in adolescents (average age 14 years) between 1966 and 1972. Follow-up examination at early intervals showed that the values for pulmonary function, particularly the vital capacity, are lower one year after operation but then definitely increase in the following years. The percentual increase is not statistically significant. The evaluation must take into account, however, that the normal values for pulmonary function in these patients increase markedly because they become 4--5 cm taller on operation. Spine fusions using Harrington's method not only prevent deterioration of pulmonary function but also lead to its improvement. Further evaluations should be carried out to discover to what degree scoliotic patients are trainable without increasing the danger of pulmonary vascular obstruction.
The case history of seven children aged 1 5/12 to 5 9/12 years with non tuberculous bacterial pericarditis, observed in the last 8 years at the University children's hospitals of Basle, Berne and Zurich is reported. The history showed febrile illness of 3--14 days duration, which led to an admission diagnosis of pneumonia, angina or pseudocroup. From the signs of heart failure and cardiomegaly on chest X-ray the differential diagnosis of myocardial disease or pericardial effusion was made. The ECG-changes were uncharacteristic, and a friction rub and pulsus paradoxus was encountered once only. The effusion diagnosis should preferably be substantiated by a non-invasive method (scintigram, echocardiogram) as diagnostic pericardiocentesis does often not allow to aspirate the thick pus through the needle. Diagnostic and therapeutic surgical pericardiotomy with consecutive drainage is therefore mandatory. Halothane should be avoided as an anesthetic for this procedure of hemodynamic reasons. With surgery and antibiotics the recovery rate in our series was 100%, and no pericardial constriction was observed on follow-up 1 to 8 years later.
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Atrial septal defect, secundum type, is rarely diagnosed and seldom produces symptoms in infancy. 7 patients, aged between 2 weeks and 8 months, who developed congestive failure, are presented. 6 of them had an atrial LR-shunt documented at cardiac catheterization. 1 diagnosis was made at post mortem in the only infant who died. The clinical signs of an ASD do not vary from those normally found in the older child; the causes for early failure are probably rapidly decreasing pulmonary vascular reistance and disturbances of left ventricular compliance. 6 infants improved with conservative or no treatment, although spontaneous closure or significant diminution of the shunt did not occur. Surgical closure can be deferred to a later optimal age for operation. ASD secundum type should be considered as a cause of heart failure in the neonate and infant.
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