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Biomedical subjects

M Russo

Publications and source records attributed to M Russo.

At least 271 records · Page 15Linked to original sources
PubMed1976

Effects of fructose infusions in patients suffering from acute viral hepatitis.

Two groups of patients suffering from uncomplicated viral hepatitis were treated for seven consecutive days with intravenous infusions of fructose and glucose, respectively (1 gram per kilogram body weight per diem). Serum transaminases were determined daily as were total bilirubin and uric acid levels. No statistically significant variations in the values of these tests were observed between the two groups of patients. Serum lactic and pyruvic acid concentrations were also determined both before and after infusion during the first three days of treatment. Blood lactic and pyruvic acid levels were found to rise significantly after fructose infusion, but not after glucose infusion. These changes, however, were limited and did not affect the lactate/pyruvate ratio.

Acute Disease↗
PubMed1975

Respiratory activity of Ehrlich ascites tumour cell nuclei.

1. Intact Ehrlich ascites tumour cells exhibit a residual respiration which is insensitive to site-specific inhibitors of mitochrondrial electron transport. Treatment of the tumour-bearing mice with phenobarbital does not influence the rate of this inhibitor-resistant respiration. 2. Among the respiratory pigments analysed spectrophotometrically in the microsomal fraction prepared from ascites cells, only small amounts of flavoproteins (NADH-cytochrome b5 reductase and NADPH-cytochrome c reductase) were detectable. 3. Ascites-cell nuclei respire with NADH or NADPH, but not with succinate, as substrates and the respiration is unaffected by inhibitors of mitochondrial electron and energy transfer. These nuclei contain cytochrome b5, whereas cytochrome P-450 or mitochondrial-like cytochromes are lacking. 4. It is concluded that the NAD(P)H-dependent electron transport in nuclei is responsible for the inhibitor-insensitive O2 uptake of intact cells. Conversely, mixed function oxidation reactions of the endoplasmic reticulum have no role in this connection. Moreover, it is assumed that nuclear respiration is involved in the control of the cellular redox potential. 5. The relevance of the data obtained with respect to some assumptions concerning the biogenesis of the endoplasmic reticulum is discussed.

Aminopyrine↗
PubMed1975

Activation energy, relative substrate specificity and optimum pH of guanase from humanrat, mouse and guinea pig sera and tissues.

Some properties of serum and tissue guanase from man, rat, mouse and guinea pig have been studied. Serum guanase differs from tissue guanase in activation energy in the human species and in guinea pig. The mouse and rat brain enzyme differs from the liver and kidney enzyme. The guanase of each species differs from the enzyme of the other species in one or more properties.

Acute Disease↗