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Biomedical subjects

M Runge

Publications and source records attributed to M Runge.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Melorheostosis. Apropos of a localization in the hand].

The authors describe a case of melorheostosis localised in the hand. Melorheostosis is an unusual affection. The first signs appear in some cases at birth, but the disease is often diagnosed during the fourth decade. Clinical symptoms are pain, ankylosis, the deformation provoked by the lesion of soft tissues and especially limitation of motion. Radiographs permit the diagnosis: opacities parallel to the diaphysis with a "monomelic" topography. The natural history of the condition is characterized by the possibility of extension of the disease. Operative treatment is rarely indicated.

Ankylosis↗
PubMed1986

[Changes in immunologic parameters following heart operations with special reference to the postcardiotomy syndrome].

In 29 patients (twelve female, 17 male) the following immunologic parameters were examined before and between days 1 to 3, 6 to 8, 13 to 15 and 20 to 22 after open-heart surgery: T-lymphocytes; immunoglobulins IgG, IgM, IgA, IgE; complement factors C3, C4 and the autoantibodies (Anti-DNA, myocardial antibodies, SMA, ANA, AMA) to assess changes in these parameters and their relationship to postoperative complications, in particular post-cardiotomy-syndrome (PCS). PCS was found in five patients (17.2%), in three fully developed, in two in a partial form. In the very early (first to third day) postoperative course, significant suppression of most parameters was found, most likely due to tissue traumatization intraoperatively as well as to the extracorporeal circulation. There was suppression of T-lymphocytes, immunoglobulins IgG, IgM and IgA and the complement factors C3 and C4. The IgE rose slightly. The serum IgM level appears to be of prognostic relevance since the patients with IgM suppression had a higher incidence of postoperative complications (PCS, pancreatitis). In the later postoperative course IgM, C3 and C4 significantly exceeded the preoperative values. The rise in IgM can be explained as an immunologic answer to a subclinical infection or to an immunization by autoantigenic tissue. The rise in C3 and C4 was interpreted as an acute phase reaction. These changes, however, had no influence on the postoperative course of the autoantibodies, only subsarcolemmal myocardial antibodies were found preoperatively; in four of the five patients with PCS, these myocardial antibodies were present prior to surgery. Postoperative myocardial antibodies were found in 75% of the patients. In all probability they are only indicative of nonspecific myocardial lesions.

Adult↗
PubMed1985

Kinetics of serum creatine kinase and creatine kinase-MB after intracoronary thrombolysis.

The kinetics of the activity of total creatine kinase (CK) and creatine phosphokinase isoenzyme muscle-brain were investigated in 48 patients with acute myocardial infarction after successful intracoronary thrombolysis, and compared to the enzyme activities in 17 patients in whom thrombolysis failed. CK activity peaked significantly earlier after a successful thrombolysis than after an unsuccessful attempt: in patients with successful thrombolysis, CKmax = 10.5 +/- 3.7 h and in patients with an unsuccessful attempt, CKmax = 19.3 +/- 5.9 h; p less than or equal to 0.05. The area under the activity time curve after successful thrombolysis was significantly smaller than after unsuccessful thrombolysis: in patients with successful thrombolysis, CK area = 25,255 U/l per day and in patients with an unsuccessful attempt, CK area = 32,602 U/l per day; p = 0.015. There was a negative correlation between the area under the CK serum curve after successful thrombolysis, and the change of regional wall motion at the site of the acute infarct (p less than or equal to 0.05). From the smaller area under the CK curve in patients after successful thrombolysis, and the significant negative correlation of this measurement with regional left ventricular wall motion, we conclude that myocardial salvage after intracoronary thrombolysis can be assessed by serial CK measurements.

Coronary Circulation↗
PubMed1984

[A rarely recognized metastatic localization. Secondary involvement of the occipito-cervical joint].

280 patients presenting osteophilic tumors were evaluated by conventional tomography of the cervical spine. Metastasis were found in 120 cases among which 70% had no symptoms. Axis was first concerned and sometimes lesions could not be detected on plain radiographs. Authors insist on the need of a systematic cervical spine tomographic study in patients with osteophilic tumors.

Cervical Vertebrae↗
PubMed1983

[Poisoning caused by the organophosphate parathion (E-605)].

In a 41-year-old patient administration of 5 g parathion led to respiratory failure and unconsciousness. Ventilatory support and antidote therapy were initiated early. However, only extensive gastric lavage and lowering of the plasma concentration by hemoperfusion with activated carbon resulted in the crucial elimination of the poison. Antidote and supportive measures may overcome the hazards of cholinesterase-inhibition, but not the direct toxic effect on the cardiovascular system which is currently regarded as the predominant cause of death.

Adult↗
PubMed1983

Pharmacokinetics of tocainide in patients with renal dysfunction and during haemodialysis.

The disposition of tocainide was studied in 15 patients with renal dysfunction. In 9 with total renal failure, the plasma half-life ranged from 16.6 to 42.7 h and total plasma clearance from 35 to 94 ml/min. The longest half-lives were found in 1 patient with cirrhosis, 3 taking the enzyme inhibitor allopurinol, and 1 on cimetidine. The mean half-life in the remaining patients was 22.3 +/- 4.8 h (+/- SD). During a 4 h haemodialysis, the half-life in the 9 patients decreased to 8.5 +/- 4.6 h, which was calculated to correspond to removal of 25 +/- 14% of the drug from the body. In 6 patients with impaired renal function (creatinine clearance 10-55 ml/min) the tocainide half-life ranged from 13.2 to 22.0 h and total plasma clearance from 72 to 122 ml/min. One patient was taking allopurinol and 1 dihydralazine, and the mean half-life in the others was 19.2 +/- 4.0 h. The apparent volume of distribution was similar to that found previously in healthy subjects. The results suggest that tocainide elimination is predictably reduced in patients with renal disease.

Aged↗
PubMed1983

[Complete fracture-dislocation of thoracic vertebrae 8 and 9 without neurological complications. Description of the injury. Therapeutic deductions].

The author has seen one case of complete fracture dislocation between the 8th and 9th thoracic vertebrae without paraplegia. An analysis of the lesion was made by tomodensitometry. It is concluded that the absence of a lesion of the spinal cord was due to an associated fracture of half of the posterior arch of the 8th thoracic vertebra. The treatment was based on conservative reduction and fixation by a halo cast. A review of the literature has shown only one similar case.

Adult↗
PubMed1983

[Cardiac impulse generation and conduction in patients with long-term insulin-dependent diabetes mellitus].

In a selected group of 14 diabetic patients (seven women, seven men) with an average age of 38 years, average duration of diabetes 20 years, all with end-organ manifestations but without hypertension or previous myocardial infarct, His bundle electrography at resting conditions and during programmed electrical stimulation was carried out to determine whether diabetes mellitus, alone, affects meaningful disturbances of impulse generation and conduction. The sinus node recovery time, conduction time through the atrium, the AV-node and the His-Purkinje system as well as the effective and functional refractory periods of the atrium and AV-node were determined. At rest, all patients had normal findings. During atrial stimulation, two patients were found to have intraatrial conduction disturbances and one patient had impaired AV-nodal conduction reserve; the latter had diminished 1:1 conduction through the AV-node during atrial stimulation. In general, however, diabetes mellitus, alone, does not appear to be of clinically-relevant pathologic importance for the development of rhythm disturbances at the levels of the sinus node and/or the AV-node and His bundle system.

Adult↗
PubMed1982

[Cardiac involvement in sarcoidosis (author's transl)].

Standard electrocardiogram (ECG), His-bundle electrogram and biphasic thallium myocardial scanning was undertaken in 13 patients with histologically confirmed sarcoidosis (lung stages I--III). Changes in the standard ECG were present in five (sinus bradycardia, A-V nodal and intraventricular conduction disturbances, non-specific S-T--T changes). The His-bundle electrogram was abnormal in four of eleven patients in whom it was recorded (sick-sinus syndrome, supraventricular extrasystoles, damage to A-V node and supraventricular extrasystoles, damage to A-V node and intraventricular conduction disturbances). In seven of twelve patients who had thallium scans there was a definite irreversible defect, questionable abnormality in three others. Seven of ten patients who had all three tests had definite abnormalities in at least one of them. The electrophysiological findings and the abnormal scans point to cardiac involvement in sarcoidosis.

Adult↗
PubMed1982

[Nephrotic syndrome as indication for one-stage bilateral renal embolisation (author's transl)].

A 42-year-old patient suffered from a nephrotic syndrome due to primary perireticular amyloidosis. One year after diagnosis the renal protein loss increased to 40 g/d within a short time so that sufficient substitution was no longer possible. The creatinine clearance was 7-10 ml/min so that haemodialysis was performed as a vital measure to remove excessive fluid. Two weeks later, as an alternative to surgical bilateral nephrectomy, simultaneous bilateral renal embolisation with Ethibloc was done without complications. A small artery to the left lower pole was spared from embolisation. Computer tomographic follow-up showed a residual parenchymal perfusion in the subcapsular and left lower pole areas so that metabolic functions of the renal parenchyma persisted. Plasma renin activity decreased to subnormal levels, the erythropoietin plasma level remained in the lower range of normal. "Medical binephrectomy" should be considered more often as a therapeutic alternative to surgery in therapy-resistant nephrotic syndrome on account of its advantage of preserved metabolic renal function.

Adult↗