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Biomedical subjects

M Rowe

Publications and source records attributed to M Rowe.

191 records · Page 11Linked to original sources
PubMed1974

Inhibition within the trigeminal nucleus induced by afferent inputs and its influence on stimulus coding by mechanosensitive neurones.

1. In decerebrate, unanaesthetized cats two thirds of slowly adapting mechanosensitive neurones sampled in the trigeminal nucleus oralis exhibited inhibition in response to conditioning mechanical stimulation applied beyond their excitatory receptive fields. The influence of this inhibition was examined over the response range of these neurones using controlled, reproducible natural stimulation procedures.2. The extent of the inhibition was graded according to the intensity of the conditioning stimulus. It was evoked most strongly by vibratory skin indentation which very effectively excites rapidly adapting afferent fibres. Tonic conditioning inputs associated with steady skin indentation were less effective.3. The slope of stimulus-response relationships constructed from responses to inputs from the excitatory receptive field was reduced in 42% of trigeminal nuclear cells in the presence of afferent-induced inhibition. In the remainder the slope was unchanged.4. There was no evidence, in the neurones subject to inhibition, of an expansion of their dynamic range defined as the range of stimulus intensities over which a neurone exhibited a graded responsiveness.5. The variability in responses of an individual neurone at a given stimulus intensity was unchanged by this inhibition.6. Analysis of the stimulus-response data using information theory statistics revealed that neurones which underwent a reduction in the slope of their stimulus-response relationship in the presence of inhibition displayed a reduced capacity for defining the intensity of skin indentation. This capacity was not modified in those neurones where the slope was unchanged by the peripherally evoked inhibition.

Action Potentials↗
PubMedDate not supplied

Experiential teaching: infection control for certified nurse's aides.

This article has described a self-care model of teaching infection control to CNAs in nursing homes. How the CNAs know and detect illness in themselves becomes the basis for learning about the presentation of acute illness in nursing home residents. This model begins with a discussion of the different meanings of feelings, then the awareness of changes during acute illness, and the factors affecting nursing home residents that change their perceptions of acute illness. With this knowledge, CNAs empathically detect the changes of common acute infectious illnesses in elderly nursing home residents to accomplish infection control. This model uses self-care as a motivational tool, blending greater knowledge with self-confidence.

Aged↗
PubMedDate not supplied

How to develop and sustain a peer-mentored research work group.

Most collaborative research models in nursing focus on hierachical structures in which an identified expert or leader directs and/or guides others in conducting research. The authors propose a peer-mentored model of collaborative research that promotes collegial participation, maximizes the use of each member's expertise, and enhances skill development within the group. This article is a description of the evolution of the Dementia Research Work Group within the Decker School of Nursing at Binghamton University. Emphasis is placed on how to create and nurture a peer-mentored research work group as well as what has been learned from the process.

Humans↗
PubMedDate not supplied

Epstein-Barr virus-positive Burkitt's lymphoma cells not recognized by virus-specific T-cell surveillance.

The pathogenesis of Epstein-Barr (EB) virus-positive Burkitt's lymphoma (BL) appears to involve the combined actions of virus-induced B-cell proliferation, and a rare chromosomal translocation juxtaposing c-myc and immunoglobulin gene loci in a single B cell; holoendemic malarial infection in some way facilitates the oncogenic process. Outgrowth of the EB virus-positive tumour suggests either breakdown or evasion of those immune controls, in particular cytotoxic T-cell responses against the virus-induced lymphocyte-detected membrane antigen LYDMA, which limit virus-infected B-cell numbers in healthy virus carriers. Immunosuppression, such as that which malarial infection may induce, cannot itself be a sufficient explanation in this regard since our studies have identified a number of BL patients who retain detectable LYDMA-specific T-cell surveillance. The present work shows that in many cases of virus-associated BL, the emerging malignant clone is insensitive to such surveillance. Several EB virus-positive BL cell lines, recently established in vitro and expressing the class I histocompatibility locus antigens (HLAs) which restrict cytotoxic T-cell function, were not killed by HLA-matched LYDMA-specific effector populations in assays where the EB virus-positive lymphoblastoid cell line (LCL), derived from normal B cells of the same patient, sustained high levels of lysis.

Antigens, Surface↗
PubMedDate not supplied

Directional coronary atherectomy for the treatment of coronary lesions with abnormal contour.

Directional coronary atherectomy is a newly developed percutaneous transluminal procedure which excises and removes obstructive tissue from coronary arteries or saphenous vein grafts. This procedure was performed on 47 lesions with abnormal contour; 24 ulcerative lesions, 10 lesions with dissection, 7 flap-like lesions and 6 lesions with aneurysm dilatation. Overall success rate was 89%; 96% in ulcerative lesions, 70% in lesions with dissection, 86% in flap-like lesions and 100% in lesions with aneurysmal dilatation. Complications with this procedure were as follows: Vessel occlusion in 2 patients (4.5%), perforation in 1 patient (2.3%), and guiding catheter induced dissection in 1 patient (2.3%). Coronary artery bypass surgery was required in 4 patients (9.4%) for these complications. Of these, 3 patients had lesions with dissections prior to the atherectomy procedure. The success rate for lesions with abnormal contour was similar to those of 270 lesions with normal contour. In conclusion, directional coronary atherectomy is a safe and effective procedure for lesions with abnormal contour, however, outcome of a lesion with dissection is suboptimal and it needs to be approached cautiously.

Angioplasty, Balloon, Coronary↗
PubMedDate not supplied

Me and my ward.

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Nursing Service, Hospital↗