Securing healthcare applications: digital certificates and PKI.
Explore the source record for details and available documents.
Computer Security↗
Biomedical subjects
M Rothman
Publications and source records attributed to M Rothman.
Non-enhancing supratentorial malignant astrocytomas: MR features and possible mechanisms.
To clarify the MR features of supratentorial malignant astrocytic gliomas that did not exhibit contrast enhancement of MR imaging, six MR parameters were evaluated in two glioblastomas and six anaplastic astrocytomas. Moderate to marked edema, mass effect, and moderate tumor heterogeneity were noted in all cases. Hemorrhage was absent in all cases. Border definition and cyst formation or necrosis were not consistent among the tumors. Histological examination demonstrated significant vascular proliferation in two cases, and mild to moderate proliferation in six. Non-enhancing malignant astrocytic gliomas are a diagnostic challenge. Analyzing perifocal edema and heterogeneity of each mass probably provides clues for a proper diagnosis.
Adolescent↗
MR imaging of adult supratentorial astrocytomas: an attempt of semi-automatic grading.
Using multiple regression analysis, six MR parameters were correlated with three histological grades among 43 proven adult supratentorial astrocytic gliomas to ascertain important MR parameters and their optimal contributions. Analysis revealed that two parameters, border definition and tumor hemorrhage, were unreliable. Using the remaining four parameters an equation was derived: Tumor grade = 0.32 (ring enhancement) +0.29 (degree of contrast enhancement) +0.13 (heterogeneity) +0.12 (edema) +0.41. Ring enhancement was the most reliable predictor of tumor grade, followed by degree of contrast enhancement. The maximum accuracies of the "semi-automatic" approach using this equation for predicting low-grade astrocytomas, anaplastic astrocytomas, and glioblastoma multiforme were 91%, 83%, and 88%, respectively. Although "semi-automatic" grading provided relatively high accuracy, possible sampling errors and some atypical cases reduced such accuracy.
Adult↗