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Biomedical subjects

M Rossetti

Publications and source records attributed to M Rossetti.

136 records · Page 8Linked to original sources
PubMedDate not supplied

Reactive oxygen species and antioxidant status in essential arterial hypertension during therapy with dihydropyridine calcium channel antagonists.

PURPOSE: To evaluate reactive oxygen species and antioxidant status in essential arterial hypertension during therapy with dihydropiridine calcium channel antagonists. PATIENTS AND METHODS: Fifteen patients, affected by essential arterial hypertension, were examined. They received once a day oral dihydropyridine calcium antagonists for 10 weeks: five patients received felodipine (5 mg), five amlodipine (10 mg) and five lercanidipine (10 mg). The levels of end products of lipid peroxidation, free radicals and hydroperoxides and total antioxidant capacity were determined in the plasma of all subjects before and during treatment. Values are expressed as mean +/- S.E. Systolic blood pressure decreased from 171 +/- 4 to 135 +/- 6 mmHg (p < 0.01) and diastolic blood pressure decreased from 99 +/- 5 to 82 +/- 3 mmHg (p < 0.01). Hydroperoxides and free radicals decreased from 321.3 +/- 8.96 to 247.9 +/- 8.69 units (p < 0.01) and the end products of lipid peroxidation decreased from 11.0 +/- 1.93 to 6.74 +/- 1.41 nmol/ml (p < 0.01). Total antioxidant capacity increased from 0.74 +/- 0.03 to 1.05 +/- 0.05 mmol/l (p < 0.01). RESULTS: Imbalance in the pro-oxidant-antioxidant equilibrium shifts in favour of antioxydant namely oxidative stress decreases. The calcium channel antagonists decrease peripheral arterial resistances and therefore decrease or abolish relative ischaemia, moreover decrease arterial pressure and therefore normalize parietal stress on endothelial cells. As a conseguence they act on two hypothesized mechanisms of oxidative stress in hypertension. CONCLUSIONS: Dihydropyridine calcium antagonists used in this trial seem useful in hypertension because they decrease oxidative stress, and normalize of pressure values.

Adult↗
PubMedDate not supplied

CMV-specific polymeric and monomeric IgA antibodies in serum of renal transplant patients.

CMV-specific IgA, IgM and IgG antibodies were detected by ELISA in sera from 81 renal transplant patients. Twenty-seven patients were followed from transplantation; 6 patients who underwent on transplantation before the beginning of the study were followed during admissions for graft failure or acute illness; 48 outpatients were periodically monitored. One of the patient followed from transplantation experienced a primary CMV infection, serologically demonstrated by the appearance of specific IgM and IgG. Specific IgA appeared at the same time as IgM and lasted for about six months. A specific IgA response was observed in all but five recurrent CMV infections too, even when specific IgM were not present. In all outpatients periodically monitored for CMV serology specific IgA were not found. About specific IgA polimerization, a transient marked polymeric IgA (p-IgA) response was observed in only the primary infection whereas in all the other IgA positive patients, specific IgA were represented by monomers (m-IgA).

Adult↗
PubMedDate not supplied

[Life with hiatal hernias and reflux disease. An historical synthesis and an update].

By long experience with the problems on hiatal hernias and reflux the author summarizes and analyzes errors and progress in development, interpretation, diagnostic methods and treatment. After the pioneer work done by Akerlund 1926 the hiatal hernia was a sometimes dangerous surgical target. It remained for a long time a gastroenterological prima donna, responsible of all sorts of symptoms. Thoracal or abdominal approach and repair were high risk procedures with logically bad results. After a long way of mistakes and researches hiatal hernias remain a concomitant factor of reflux disease and an important cause of mechanical complications and anemia by para-oesophageal and mixed forms. The studies about pathogenesis and consequences of the reflux are extensive and important in the second half of our century. The treatment of reflux disease was for a long time preponderantly surgical, since 1970 increasingly pharmacological. By critical review of many methods and technics the author describes the birth of fundoplication 1955, the standard procedure with the anterior wall, and analyzes the actual indications despite the long list of efficient drugs. The mixed or para-oesophageal forms of hiatal hernia remain always a surgical problem. The method of choice is here a double gastropexy with fundoplication after regulated partial closure of the big hiatus communis by abdominal approach. The choice of the surgical procedure and the quality of results depend of the school and competence of the surgeon. The rarity of the indication to surgery (nowadays between conventional and, perhaps, mini invasive possibilities) is a problem for the training-program of the young surgeons of the new generation.

Esophagostomy↗
PubMedDate not supplied

[Ernst Ferdinand Sauerbruch (1875-1951)].

The author remembers by invitation of the review a very master of the German surgery, his pioneership and his severe and efficient management. During his last years his image was grieved by disease and political disorders; after his death by movies and sensational books. Nevertheless remain his name and surgical deeds part of our history, especially his work establishing chest surgery.

General Surgery↗