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Biomedical subjects

M Rosnowska

Publications and source records attributed to M Rosnowska.

47 records · Page 3Linked to original sources
PubMedDate not supplied

[Gamma globulin subfractions and immunoglobulin G in the cerebrospinal fluid of patients with multiple sclerosis, subacute sclerosing panencephalitis and other diseases of the nervous system].

CSF samples were obtained from 22 patients with multiple sclerosis, 14 patients with subacute sclerosis panencephalitis, and 10 with neuroses or headaches. Most samples were investigated simultaneously by a sensitive method of electrophoresis in polyacrylamide gel (PE) and radial immunodiffusion (RID). The absolute IgG concentration was in multiple sclerosis 6.8 +/- 3.3 mg/100 ml, and in SSPE 21.4 +/- 16.8 mg/100 ml and it was higher than in control subjects (p less than 0.01). In 84% of MS patients the Bauer index (IgG: total protein) was raised, 72% had relatively raised subfractions gamma 2-gamma 3 in PE, 64% had higher absolute concentration of GG (0.045 g/l or more) and 63% had increased proportion of one of gammaglobulin subfractions (over 4%). Of positive diagnostic importance was a rise of the IgG: total protein index, since 7 patients with SM (31%) with normal per cent gammaglobulin level (less than or equal to 13%) had an evident rise of this index. Raised value of the index IgG: total protein (greater than or equal to 10%) was observed also in 100% of SSPE cases, while in 92% the proportional value of one of gamma globulin subfractions was increased (over 4%), in 92% the subfractions gamma 3-gamma 4 were increased, in 85-86% of patients the relative (over 13%) and absolute (0.045 g/l or more) levels of gammaglobulins were increased. The index beta/gamma in MS and SSPE was 0.85 and 0.57 respectively, and was significantly lower than in patients with headaches. The authors discuss the diagnostic value of these findings.

Epilepsy↗
PubMedDate not supplied

[The HDL cholesterol level in patients treated with antiepileptic drugs].

Total cholesterol, HDL cholesterol, and HDL2 and HDL3 cholesterol were estimated in individuals undergoing anticonvulsant therapy. Significantly higher, than in the corresponding control groups HDL concentration, concerning mainly HDL2 subfraction was found in female epileptic and in male alcoholic epileptic patients. It was observed that higher drug levels were accompanied by higher HDL cholesterol values. In alcohol addicted subjects undergoing anticonvulsant therapy low-nontherapeutic serum drug concentration was often observed. In spite of this, HDL levels were high. This could result from an additional induction of cytochrome P-450 caused by alcohol and an accelerated oxidation of the drugs. This observation indicates that frequent control of drug concentration in these patients is desirable.

Adolescent↗
PubMedDate not supplied

[Evaluation of the biological availability of 2 carbamazepine preparations].

The biological availability was determined of two carbamazepine preparations: Amizepin POLFA and Tegretol GEIGY in tablets. The study was carried out in 10 patients giving them the drug in doses of 400 mg by the crossover method at an interval of 3 weeks. The statistical analysis of the mean maximal values, mean times of reaching of maximal concentrations, and mean areas under the curve of serum carbamazepine concentration changes for both forms of the drug showed a comparable biological availability of Amizepin and Tegretol. The relative degree of bioavailability of Amizepin amounted to 98% of that of Tegretol. The values of pharmacokinetic parameters of both drugs were compared. The value of distribution volume was greater in the case of Tegretol, and the difference was statistically significant. No significant differences were found between the remaining calculated parameters.

Adult↗
PubMedDate not supplied

[Cerebrospinal fluid prostaglandins in multiple sclerosis. Preliminary report].

In 14 patients with multiple sclerosis exacerbations, in 7 with slowly progressive or stationary disease, and 5 patients with intervertebral disc prolapse the levels of total prostaglandins (PGs) were determined in the cerebrospinal fluid. The determinations were done by bioassay according to Ferreira and Vane. In multiple sclerosis patients the level of total PGs was significantly higher in the cerebrospinal fluid (286 +/- 20.3 pg/ml) than in patients with disc prolapse (142 +/- 7.7 pg/ml) (p less than 0.01). This rise in this level might be due to increased synthesis of PGs by activated macrophages, lymphocytes and neutrophils or to increased hypothalamic response to stress.

Adult↗
PubMedDate not supplied

[Effect of short-term administration of sunflower oil on the blood serum level of linoleic and arachidonic acids and lipids in multiple sclerosis].

Patients with multiple sclerosis had an oral load of sunflower seed oil in daily doses of 40 g during five days. This daily doses contained 27 g of linoleic acid (LA). Prior and after diet supplementation with sunflower seed oil the levels of linoleic and arachidonic acids were determined in the serum of patients. The values were expressed as relative percentages of total fatty acids. Before addition of sunflower oil to the diet the serum levels of linoleic acid (LA) and arachidonic acid (AA) were in these patients significantly lower than in controls amounting to 17.0% and 1.05% (p less than 0.001). After addition of sunflower oil the levels of LA and AA rose to 32.7% and 3.02%. The concentration of total lipids and non-esterified fatty acids in the serum increased also significantly after addition of sunflower oil. Determinations of LA and AA 10 days after withdrawal of sunflower oil showed that their levels were 23.7% and 1.95% respectively. In 2 patients addition of sunflower oil only slightly changed the very low serum LA level. These results indicate that LA and AA deficiency in patients with multiple sclerosis has the character of a non-specific dietary deficiency mainly, although the role of genetic factors controlling the levels of polyunsaturated fatty acids cannot be ruled out.

Adult↗
PubMedDate not supplied

[Serum lipid peroxides in alcoholic patients].

The study presents the estimations of serum lipid peroxide (LPx) concentrations in alcoholic patients during acute ethanol intoxication and in abstinence period. The increase of lipid metabolism in alcoholic drunkenness suggests that LPx plays marked role in this turnover.

Adult↗
PubMedDate not supplied

[Leukotrienes in cerebrospinal fluid of patients with subacute sclerosing panencephalitis].

In the cerebrospinal fluid of two groups of patients with subacute sclerosing panencephalitis (SSPE), the determinations of LTB4 and LTC4 leukotriene concentrations were performed by radioimmunoassay (RIA). In the first group of 10 patients with chronic SSPE (from 2 to 11 years), the LTB4 and LTC4 levels were 94.8 +/- 17.0 and 97.4 +/- 16.8 pg/ml respectively, and were significantly higher than those in six patients with discopathy, epilepsy and headache (p < 0.01). In the second group of 10 patients with beginning SSPE (disease duration from 1 to 11 months) LTB4 level was lower (was not different from that in the control group), while LTC4 concentration was 97.6 +/- 10.8 pg/ml and again was significantly raised. Higher LTB4 and LTC4 levels in the cerebrospinal fluid of patients with SSPE indicate that these compounds participate in chronic inflammatory reaction around cerebral veins.

Adolescent↗