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Biomedical subjects

M Rosner

Publications and source records attributed to M Rosner.

At least 91 records · Page 5Linked to original sources
PubMed1988

Choosing an intraocular lens for patients with large pupils.

Optical aberration from the positioning holes of a posterior chamber intraocular lens was encountered in three patients with wide spontaneous dilation of the pupil in scotopic conditions. One patient had a cataract extraction in his fellow eye with implantation of a posterior chamber lens without positioning holes in its optical portion and has not encountered any aberrations in that eye. We suggest that in such patients, careful preoperative measurement of the pupillary size in a dark room should be done and lenses without positioning holes on the optic should be used to prevent optical aberrations.

Darkness↗
PubMed1988

Optic nerve regeneration--new aspects.

Injury to the optic nerve and its environment provokes a process of degeneration that leads to a degenerative process resulting in an irreversible loss of visual function. We succeeded in stimulating regeneration in injured optic nerves of adult rabbits. The stimulus to regeneration was achieved by implanting in injured optic nerves of adult rabbits substances originating from growing (regenerating) optic nerves of fish or developing optic nerves of neonatal rabbits, and by delaying the degenerative process by irradiating the injured optic nerve with a low energy laser. The effect was manifested by abundant growth of new fibers across the injury site and by other manifestation of regeneration characteristics.

Animals↗
PubMed1988

Nd: YAG laser treatment of anterior chamber implantation cysts.

The development of an epithelial implantation cyst is a severe complication of anterior segment surgery and trauma. Two patients with anterior chamber implantation cysts were treated with Nd: YAG laser. One required surgical correction as the cyst reformed after each of 6 laser treatment sessions. In the other patient, the cyst reformed once, and has not recurred for 18 months since the second laser treatment. Collapse of anterior chamber implantation cysts can be achieved with Nd: YAG laser, though multiple treatment sessions may be required due to the cyst's tendency to reform.

Aged↗
PubMed1988

Prostaglandin E2 and protein levels in rabbit aqueous humor following ND:YAG laser iridotomy.

Prostaglandin E2 (PGE2) and protein levels were measured in the aqueous humor of rabbits' eyes subjected to iridotomy with the neodymium:YAG laser. Following irradiation, PGE2 levels were elevated to the highest elevation of 20.0 +/- 7.7 ng/ml (mean +/- SD) at 30 minutes as compared to control levels of 0.625 +/- 0.075 ng/ml. PGE2 concentrations progressively decreased, however, after 8 hours they remained high and did not resume control levels. Protein levels in the aqueous humor of ND:YAG irradiated eyes reached peak levels at 30 minutes to 7.8 +/- 2.2 mg/ml compared to control level of 1.3 +/- 0.4 mg/ml. A progressive decrease in protein levels was observed after peak time, but they were still above control levels, at 8 hours. Our study demonstrated that ND:YAG irradiation of the iris involves an immediate increase in PGE2 aqueous levels associated with a blood aqueous barrier disruption and augmented aqueous protein levels.

Animals↗
PubMed1988

Sequential use of argon and ND:YAG lasers to produce an iridotomy--a pilot study.

A two-step technique for laser iridotomy in difficult irides is described. The method utilizes the argon and ND:YAG lasers sequentially. Sixteen eyes were treated by two argon stretch burns and up to 35 penetrating burns that produced an iridotomy that was either imperforate or inadequate. The ND:YAG laser was then used to complete the iridotomy. In all 16 eyes an iridotomy was achieved in one session. Only two eyes had a moderate increase in pressure that was easily controlled. There were no other significant complications. Total energy levels for each laser modality were significantly lower than those previously reported using either laser alone. The sequential technique is safe and effective and is recommended for iridotomy in difficult iris types.

Female↗
PubMed1988

Prophylactic scleral buckling in perforating ocular injuries involving the posterior segment.

Twenty patients suffering from perforating injury involving the posterior segment of the eye without retinal tear or detachment underwent posterior vitrectomy. In 12 of these where traction of the retina was suspected, prophylactic scleral buckling was performed as well. Only two of these patients developed delayed retinal detachment. Six of the eight patients who did not undergo scleral buckling at the time of the vitrectomy developed this complication. This finding was statistically significant (P = .015) and supports the use of prophylactic scleral buckling in the treatment of eyes with perforating injuries involving the posterior segment to prevent delayed retinal detachment.

Adolescent↗
PubMed1987

Role of NK cells in protection of mice against herpes simplex virus-1 infection.

Natural killer (NK) cells have been implicated in the recognition and killing of a variety of virus infected target cells in vitro, yet their role in vivo remains uncertain. In these experiments, the role of NK cells in the regulation of resistance to herpes simplex virus-1 (HSV-1) was studied. Adult C57BL/6 mice are resistant to HSV-1 (HFEM strain), but are rendered highly susceptible by treatment with cyclophosphamide 24 hr prior to infection. In this model, passive transfer of 10(8) normal spleen cells or 10(7) poly I:C-treated spleen cells provided protection for 72% of the recipients. Spleen cells from NK cell-deficient beige mice similarly treated failed to engender passive protection. The phenotype of the cells responsible for transferring protection was NK1.1+, and asialo GM1+. Transfer of NK cells resulted in marked reduction of HSV titers in the livers and brains of recipients. These experiments provide direct evidence for a role for NK cells in protection against development of fatal HSV infection in mice.

Animals↗
PubMed1987

Intelligence, education, and myopia in males.

We conducted a nationwide study of the relationship among refractive error, intelligence scores, and years of schooling in 157,748 males aged 17 to 19 years. We found a strong association of myopia with both intelligence and years of school attendance. The prevalence of myopia was found to be significantly higher in the more intelligent and more educated groups. By fitting models of logistic regressions, we worked out a formula expressing the relationship among the rate of myopia, years of schooling, and intelligence level. We found that years of schooling and intelligence weigh equally in the relationship with myopia.

Adolescent↗
PubMed1987

A method of repair for quadriceps tendon or patellar ligament (tendon) ruptures without cast immobilization. Preliminary report.

The quadriceps tendon and patellar tendon (ligament) were repaired with a Dacron vascular graft used as a tension suture material. In cases of quadriceps tendon ruptures, the Dacron graft is passed transversely through the patellar ligament just below the patella and crossed transversely at the level of the musculotendinous junction with two loops applying tension to the tendon, which brings the tendon ends together by creating a solid structure. In cases of patellar ligament ruptures, the Dacron graft is passed through a hole in the tibia posteriorly to the tibial tuberosity instead of through the patellar ligament below the patella. This technique enables early mobilization on the first day after surgery. The technique was first tested on six dogs with severed quadriceps tendons and patellar ligaments that were repaired with this suture method. All of the animals recovered from surgery and walked and ran normally on the repaired legs within 27 days and with only mild limping after 17 days. The technique was then used on six patients, four with complete quadriceps tendon rupture and two with complete tear (avulsion) of the patellar ligament (tendon). In all of the patients, excellent surgical results were obtained and leg immobilization was virtually eliminated. Physical therapy was prescribed the first day after surgery. The rehabilitation period was significantly reduced.

Animals↗
PubMed1985

Pterygium, solar ultraviolet radiation and myopia.

A retrospective study of 93 patients who underwent pterygium excision revealed a low prevalence of myopia in comparison with normal population. These results support the theory that solar ultraviolet radiation is a contributory factor in the formation in pterygium and some protection against this radiation is afforded by continuously worn myopic correction.

Female↗