Biomedical subjects
M Rosman
Publications and source records attributed to M Rosman.
Leukocyte purine phosphoribosyltransferases in human leukemias sensitive and resistant to 6-thiopurines.
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Hydrolysis of fMet-tRNA by peptidyl transferase.
Escherichia coli and rabbit reticulocyte (f[(3)H]Met-tRNA.AUG.ribosome) intermediates undergo hydrolysis, with release of f[(3)H]methionine, upon addition of tRNA or CpCpA in the presence of acetone. This ribosomal catalyzed reaction has similar requirements, pH optimum, and antibiotic sensitivity to those of peptidyl transferase. Two antibiotics, lincomycin with E. coli ribosomes and anisomycin with reticulocyte ribosomes, inhibit peptide-bond formation and transesterification activities of peptidyl transferase, but stimulate hydrolysis of f[(3)H]Met-tRNA. Earlier studies have suggested peptidyl transferase activity is essential for R factor-dependent hydrolysis of f((3)H)Met-tRNA. These studies indicate that peptidyl transferase has the capacity for f((3)H)Met-tRNA hydrolysis and, therefore, may be responsible for peptidyl-tRNA cleavage during peptide chain termination.
Transesterification by peptidyl transferase.
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Interaction of guanosine triphosphate with E. coli soluble transfer factors.
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Congenital "high-arched (cavus) forefoot"--a newly described deformity and surgical correction.
A previously unreported forefoot deformity (cavus) is described, clinically and radiologically, and a surgical operation for successful correction is detailed.
Preoperative Ilizarov frame construction for correction of ankle and foot deformities.
The Ilizarov method is being used increasingly to correct many orthopedic deformities. The frames required for ankle and foot deformity correction are among the most difficult to construct owing to the complexity of the deformities which must be corrected. A technique using a rubberized material (Pedilen) to create an exact replica of a preoperative ankle and foot deformity is described. This exact model, both in size and shape, may then be used on a workbench to preconstruct an Ilizarov frame that resembles the patient's deformity exactly in three dimensions with respect to size and shape. This allows thoughtful frame construction before operation reducing operating time and minimizing frustrations that may arise with complex deformities.
Peritalar dislocations in children.
Five patients with peritalar dislocations were identified in a search for injuries of the talus. We report the mechanism, management, and outcome of their injuries and compare and contrast the injuries with the same injury in adults. To our knowledge, our series is the only small series of this rare injury in children. Four of our 5 patients had acceptable results with respect to pain and gait. In two patients, the peritalar dislocation was missed, necessitating a delay in management because more attention is focused on obvious fractures, when they exist.
Medial osteochondritis of the talus in children: review and new surgical management.
Review of the management of medial osteochondritis of the talus in the young patient has revealed the poor results of casting and the equivocal results of past surgical options. A new surgical technique of bone grafting is described. The results in six patients treated with bone grafting are compared with the results in 10 patients treated by excision. Because of the more favorable results following bone grafting, we recommend it as primary treatment of this condition in children and adolescents.
Fracture of the capitulum humeri in children: a rare injury, often misdiagnosed.
Fracture of the capitulum humeri is very uncommon in children. Two typical cases in adolescent girls illustrate the importance of distinguishing capitulum from lateral humeral condyle fractures, and of the feasibility of treatment of the former by excisional surgery.