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Biomedical subjects

M Rosbash

Publications and source records attributed to M Rosbash.

200 records · Page 12Linked to original sources

A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene.

Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of the cloned cDNAs can restore clock function to mutant arrhythmic flies.

Animals↗

Behaviour modification by in vitro mutagenesis of a variable region within the period gene of Drosophila.

The period gene of Drosophila melanogaster, implicated in the control of both the circadian and male courtship song rhythms, is found to be polymorphic. Alleles differ in the length of a region of the gene encoding a series of threonine-glycine repeat units. The phenotypes of transformed fruit flies, in which the only functional period gene lacks the entire perfect threonine-glycine repeat region, show that the effects of the period gene on the circadian and male courtship song rhythms can be dissociated.

Alleles↗