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Biomedical subjects

M Roncato

Publications and source records attributed to M Roncato.

45 records · Page 3Linked to original sources
PubMed1984

[Intra-arterial thrombolysis with the combination of urokinase and lysyl-plasminogen. 27 cases of acute arterial obliteration of the lower limbs].

Twenty-five in situ thrombolysis using Lysyl Plasminogen and low doses of urokinase were performed on 25 acute, recent and severe arterial occlusion of lower limbs. Early success were 56% and 44% with a follow up of 5 months. Complications were very limited. Thus the thrombolytic treatment used in this study appears as effective as locally administered streptokinase but higher tolerated. It seems to be able to win one of the best places in the treatment of the arterial disease of the lower limbs.

Acute Disease↗
PubMed1983

[Value of C-reactive protein in the cardiac postoperative period].

Twenty patients underwent special clinical and biological monitoring during their period of hospitalisation in the Department of cardiovascular surgery. The clinical monitoring concentrated on the patient's temperature and the search for postoperative complications; the biological part of the study was concerned with monitoring the levels of serum C-Reactive protein (CRP) as assessed by an immuno-nephelometric method. In 10 patients with a normal postoperative course the levels of this protein, an indicator of an inflammatory or infective process, were similar, giving an identical graph in all patients. On the other hand, in the 10 patients with inflammatory or infective postoperative complications, the levels of CRP were abnormal, parallel with the clinical state, sometimes rising even before the complication manifested itself clinically. It therefore seems useful and justified to measure CRP systematically, once before surgery and at least once daily in the postoperative period. The frequency of this investigation could be increased in patients with difficult or complex postoperative courses. A high CRP, even with a normal temperature, should alert the surgeon to a complication or to the inefficacy of anti-inflammatory or anti-infective therapy. These results confirm those published by other surgical teams, both in cardiovascular surgery and traumatology.

C-Reactive Protein↗
PubMed1981

[Consumption hypocomplementemia: relation between hemolytic and immunochemical assays of C4 in serum (author's transl)].

The aim of the study is to compare two methods for the measurement of the fourth human complement component through its hemolytic activity and immunodiffusion properties in 35 healthy subjects and 35 patients with immunological complement depletion. For the healthy subjects, the results show a highly significant correlation between the two methods (the coefficient of correlation is + 0.80). On the contrary, there is no correlation between the two assays for the patients suffering from consumption hypocomplementemia. The reasons of this discrepancy are discussed.

Adolescent↗
PubMed1981

[Comparison of consumption kinetics of the C4 and C2 components of complement by immune complexes "in vitro" (author's transl)].

We study the consumption kinetic of the fourth and second component of complement by the C1 esterase in different systems with EA or EAC1 and fresh NHS, or functionally purified C4 and C2 preparations. The results show that the two kinetics are similar with a comparable decrease in both C4 and C2 activities till 90 seconds (the mean residual values are from 21 to 34% at this time). The results show moreover that the consumption of the C2 component requires necessarily the presence of the C4 component. The C4 reaction kinetic compared with the C2 "in vitro" one refutes the hypothesis of a greater sensitivity of the C4 component compared with the C2, for the enzymatic action of the C1 esterase. So, a discrepancy in the reaction speed cannot be evoked in order to explain the obvious C4 depression in the consumption hypocomplementemia, and different hypothesis have to be investigated, such as, for instance, a lower synthesis rate of the C4 component compared with the C2 one.

Animals↗
PubMed1980

[Anaphylactoid shock during intravenous urography. Possible interaction between complement and fibrinolytic systems (author's transl)].

Shock associated with deep coma was induced by an injection of methylglucamine iodotalamate for descending urography to a 56-years old man without any history of atopy. Under intensive care the acute symptoms were controlled, and consciousness returned to a normal level within 15 days, but the patient remained with right-side monoplegia. Biological investigations showed a fall in total haemolytic complement (CH50) and in C1, C4, C2 and C3 components, as well as in B-factor. Acute fibrinolysis and hypocalcaemia were also present. Two main mechanisms seem to be responsible for the accident : intolerance to the drug, with direct activation of the complement and fibrinolytic systems ; and an immuno-allergic reaction where the contrast medium behaved like an hapten, which became antigenic in the body.

Anaphylaxis↗
PubMed1979

[Consumption hypocomplementemia: comparative value of haemolytic and protein estimations of the components of the classical pathway (author's transl)].

Titrations of total complement (CH50) and of the different components of the classical pathway of the complement system in patients with supposed consumption hypocomplementemia, show that the complement depression involves in an order of decreasing severity hemolytic C4, hemolytic C2, total complement, hemolytic C1, protein C4 and protein C3. These results as well as correlative studies between these different parameters suggest that C4 is the most specific target of activited C1 esterase (C1s). They stress the interest of hemolytic titrations as well as the strong limitations of protein titrations.

Adolescent↗
PubMedDate not supplied

Peripheral artery thrombolysis with urokinase-lys-plasminogen. A disappointing experience.

Thirty-five patients with peripheral arterial occlusion were treated by intra-arterial infusion of low dose urokinase associated with bolus of lys-plasminogen. Systemic fibrinolysis was moderate, thrombolysis was achieved in 26 patients (74%). Only one patient required blood transfusion, five patients (14%) had distal emboli. Infection at the catheter entry site occurred in 2 patients, 3 patients experienced proximal embolism. Six patients required leg amputation, 4 died, in 2 of them deaths were related to arterial catheterization. Local thrombolysis with limited systemic fibrinolysis is associated to a high rate of catheter-related complications.

Adult↗
PubMedDate not supplied

[Immunofixation in agarose gel for the identification of monoclonal immunoglobulins].

Immunoelectrophoresis is the usual method for identifying abnormal bands detected by zone electrophoresis. In the last few years, a new technique has appeared, that of immunofixation. This method involves an antibody-antigen precipitation reaction in an electrophoretic strip. The aim of the present study was to compare immunofixation (IFX) and immunoelectrophoresis (IEP) of 101 sera with one or more homogeneous bands upon serum protein electrophoresis: among them 97 bands were subsequently characterized by IFX on agarose gel, and only 50 by IEP. IF appears to be a more sensitive technique for characterizing M-components, especially those with multiple bands. While more rapid than IEP, this new procedure does not seem appropriate for routine use.

Blood Protein Electrophoresis↗