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Biomedical subjects

M Romanov

Publications and source records attributed to M Romanov.

4 recordsLinked to original sources
PubMed1996

Low- and standard-dose depot haloperidol combined with targeted oral neuroleptics.

Nine patients receiving a low dose (25 mg) and ten receiving a standard dose (150 mg) of depot haloperidol every four weeks were assessed every three months for two years. Patients also received targeted oral neuroleptics as needed. No significant between-group differences were found in clinical outcome as measured by number of hospital admissions, days hospitalized, scores on the Brief Psychiatric Rating Scale and the Global Assessment Scale, and level of extrapyramidal symptoms. Combining low-dose depot and targeted oral neuroleptics was at least as effective as using a standard depot dose and for many patients may provide the best way to reach the minimal effective dose for maintenance treatment.

Administration, Oral↗
PubMed1995

A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression.

One hundred and sixty-three patients with major depression were randomly assigned to treatment with mirtazapine or doxepin for 6 weeks in a double-blind clinical trial. Initially, patients received mirtazapine 20 mg/day or doxepin 75 mg/day; dosages were then titrated up to a maximum of 60 mg/day and 300 mg/day, respectively. Both drugs produced considerable improvement in depressive symptoms with no statistically significant differences between the two patient groups. In the mirtazapine group only two patients prematurely terminated the study due to adverse drug experiences, as compared to six in the doxepin-treated group. Moreover, doxepin-treated patients complained more frequently of dry mouth and movement disorders. In conclusion, mirtazapine is an effective treatment for major depression and appears to offer advantages in tolerability over doxepin.

Adolescent↗