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Biomedical subjects

M Roland

Publications and source records attributed to M Roland.

At least 37 records · Page 2Linked to original sources
PubMed2001

Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease.

BACKGROUND: Endothelin (ET)-l is a bronchoconstrictor peptide produced in the airways. It has been implicated in the pathogenesis of asthma and virally mediated airway inflammation and may play a role in exacerbations of chronic obstructive pulmonary disease (COPD). METHODS: Seventy one patients with COPD were followed prospectively and sampled for plasma and sputum ET-1 levels when stable and during an exacerbation. Sputum was also examined for cytokines, human rhinovirus, and Chlamydia pneumoniae. RESULTS: Plasma ET-1 levels were available for 67 patients with stable COPD (mean (SD) 0.58 (0.31) pg/ml); 28 pairs of stable-exacerbation plasma samples had a mean stable ET-1 level of 0.54 (0.30) pg/ml rising to 0.67 (0.35) pg/ml at exacerbation (mean difference 0.13, 95% confidence interval (CI) 0.04 to 0.21, p = 0.004). Plasma ET-1 levels in the 67 patients with stable COPD were inversely correlated with baseline forced expiratory volume in one second (FEV(1); r = -0. 29, p = 0.022) and forced vital capacity (FVC; r = -0.38, p = 0.002). The change in plasma ET-1 levels during an exacerbation correlated with the change in oxygen saturation (SaO(2); r = -0.41, p = 0.036). In 14 stable-exacerbation pairs of sputum samples median stable ET-1 levels were 5.37 (0.97-21.95) pg/ml rising to 34.68 (13.77-51.95) pg/ml during an exacerbation (mean difference 25.14, 95% CI 3.77 to 46.51, p = 0.028). This increase in sputum ET-1 levels correlated with the increase in plasma ET-1 levels (r = 0.917, p = 0.001) and sputum interleukin (IL)-6 levels (r = 0.718, p = 0.013). CONCLUSIONS: Sputum levels of ET-1 rise in COPD patients during an exacerbation and this is reflected by a smaller rise in plasma ET-1 levels. ET-1 may have a role in mediating airway inflammatory changes during exacerbations of COPD.

Aged↗
PubMed2001

What makes British general practitioners take part in a quality improvement scheme?

OBJECTIVES: To understand the reasons for the apparent success of a quality improvement scheme designed to produce widespread changes in chronic disease management in primary care. METHODS: Purposeful sample of 36 primary care staff, managers and specialists. Qualitative analysis of 27 interviews in East Kent Health Authority area, where, over a three-year period, more than three-quarters of general practitioners (GPs) and enrolled in a quality improvement programme which required them to meet challenging chronic disease management targets (PRImary Care Clinical Effectiveness--PRICCE). RESULTS: Major changes in clinical practice appeared to have taken place as a result of participation in PRICCE. The scheme was significantly dependent on leadership from the health authority and on local professional support. Factors that motivated GPs to take part in the project included: a desire to improve patient care; financial incentives; maintenance of professional autonomy in how to reach the targets; maintenance of professional pride; and peer pressure. Good teamworking was essential to successful completion of the project and often improved as a result of taking part. The scheme included a combination of interventions known to be effective in producing professional behavioural change. CONCLUSIONS: When managerial vision is aligned to professional values, and combined with a range of interventions known to influence professional behaviour including financial incentives, substantial changes in clinical practice can result. Lessons are drawn for future quality improvement programmes in the National Health Service.

Chronic Disease↗
PubMed2000

Randomised controlled trial comparing cost effectiveness of general practitioners and nurse practitioners in primary care.

OBJECTIVE: To compare the cost effectiveness of general practitioners and nurse practitioners as first point of contact in primary care. DESIGN: Multicentre randomised controlled trial of patients requesting an appointment the same day. SETTING: 20 general practices in England and Wales. PARTICIPANTS: 1716 patients were eligible for randomisation, of whom 1316 agreed to randomisation and 1303 subsequently attended the clinic. Data were available for analysis on 1292 patients (651 general practitioner consultations and 641 nurse practitioner consultations). MAIN OUTCOME MEASURES: Consultation process (length of consultation, examinations, prescriptions, referrals), patient satisfaction, health status, return clinic visits over two weeks, and costs. RESULTS: Nurse practitioner consultations were significantly longer than those of the general practitioners (11.57 v 7.28 min; adjusted difference 4. 20, 95% confidence interval 2.98 to 5.41), and nurses carried out more tests (8.7% v 5.6% of patients; odds ratio 1.66, 95% confidence interval 1.04 to 2.66) and asked patients to return more often (37. 2% v 24.8%; 1.93, 1.36 to 2.73). There was no significant difference in patterns of prescribing or health status outcome for the two groups. Patients were more satisfied with nurse practitioner consultations (mean score 4.40 v 4.24 for general practitioners; adjusted difference 0.18, 0.092 to 0.257). This difference remained after consultation length was controlled for. There was no significant difference in health service costs (nurse practitioner 18.ll pound sterling v general practitioner 20.70 pound sterling adjusted difference 2.33 pound sterling - 1.62 pound sterling to 6.28 pound sterling). CONCLUSIONS: The clinical care an health service costs of nurse practitioners and general practitioners were similar. If nurse practitioners were able to maintain the benefits while reducing their return consultation rate or shortening consultation times, they could be more cost effective than general practitioners.

Adolescent↗
PubMed2000

An educational intervention for front-line health professionals in the assessment and management of suicidal patients (The STORM Project).

BACKGROUND: Suicide prevention is a health priority in many countries. Improved management of suicide risk may improve suicide prevention. This study aimed to assess the feasibility of health district-wide training in the assessment and management of people at risk of suicide; and to assess the impact of training on assessment and management skills. METHODS: Staff in three health care settings, namely primary care, accident and emergency departments and mental health services (N = 359), were offered suicide risk management training in a district-wide programme, using a flexible 'facilitator' approach. The main outcomes were the rate of attendance at training, and changes in suicide risk assessment and management skills following training. RESULTS: It was possible to deliver training to 167 health professionals (47 % of those eligible) during a 6 month training period. This included 95 primary care staff (39%), 21 accident and emergency staff(42%) and 51 mental health staff (78%). Of these, 103 (69%) attended all training. A volunteer sample of 28 staff who underwent training showed improvements in skills in the assessment and management of suicide risk. Satisfaction with training was high. The expected costs of district-wide training, if it were able to produce a 2.5% reduction in the suicide rate, would be 99,747 pound sterling per suicide prevented and 3,391 pound sterling per life year gained. CONCLUSIONS: Training in the assessment and management of suicide risk can be delivered to approximately half the targeted staff in primary care, accident and emergency departments and mental health services. The current training package can improve skills and is well accepted. If it were to produce a modest fall in the suicide rate, such training would be cost-effective. However, a future training programme should develop a broader training package to reach those who will not attend.

Adult↗
PubMed2000

The General Practice Assessment Survey (GPAS): tests of data quality and measurement properties.

OBJECTIVES: The aim of this study was to describe the psychometric properties of the General Practice Assessment Survey (GPAS) and its acceptability to patients in the UK. GPAS comprises seven multiple item scales and two single item scales addressing nine key areas of primary care activity (access, technical care, communication, inter-personal care, trust, knowledge of patient, nursing care, receptionists and continuity of care). A further four single items relate to patients' perceptions of the GP's role in referral and co-ordination of care, their willingness to recommend their GP and their overall satisfaction with care received. METHODS: Two hundred consecutive patients attending routine consulting sessions at 55 inner London practices were invited to complete the GPAS questionnaire. The acceptability, reliability and validity of GPAS was assessed using standard psychometric techniques. RESULTS: Out of 11 000 patients, 7247 (66%) completed a questionnaire in a GP surgery. Fifty-five out of a separate sample of 77 patients attending one practice completed a second questionnaire mailed to them 1 week following their attendance. GPAS was acceptable to patients as evidenced by low proportions of missing data for all items, and a full range of possible scores for all but one of the nine scales. Reliability of the instrument was good. Multiple item scales had excellent internal consistency, high item-total correlations, and test-retest reliability. Scaling assumptions were confirmed, with six of the seven scales achieving 100% scaling success (convergent and discriminant validity). Construct validity was evident, although this requires further evaluation against external measures. CONCLUSIONS: GPAS is a useful instrument for assessing several important dimensions of primary care. It is acceptable, reliable and valid, and has the potential for versatility in mode of administration. It will be a useful instrument for practices, primary care groups and primary care researchers evaluating key areas of primary care activity. Further work is required to evaluate its performance in non-inner-city settings and to evaluate further its validity against external criteria.

Adolescent↗
PubMed2000

The effectiveness of preschool vision screening by health visitors.

The aim of this study was to determine the effectiveness of preschool vision surveillance by health visitors in Warrington, a district with a secondary community orthoptic service. Of the 2041 children screened by health visitors at 3-3 1/2 years 12% were referred to the orthoptist for further assessment. Sixty-three per cent of these required more than one examination by the orthoptist and 28% were subsequently referred to an ophthalmologist for further assessment. Amblyopia was detected in 11 children, 5 had squints without amblyopia, and in addition 25 children had significant refractive errors. A retrospective review of the records of children identified with amblyopia following a school entry medical at 5 years was undertaken to detect possible failure of the earlier health visitor examination (i.e. false negatives at age 3-3 1/2 years). Possible failure of early screening was found in only two children, one of whom had a minor defect only (6/9). Vision screening for children aged 3-3 1/2 years by health visitors is an effective alternative to primary screening by orthoptists. However, the use of health visitors in this role is contrary to current national guidelines. The findings suggest that using health visitors to screen vision in preschool children makes efficient use of existing routine checks and may be the best use of orthoptic time.

Child, Preschool↗
PubMed1999

Measuring quality of care with routine data: avoiding confusion between performance indicators and health outcomes.

OBJECTIVE: To investigate the impact of factors outside the control of primary care on performance indicators proposed as measures of the quality of primary care. DESIGN: Multiple regression analysis relating admission rates standardised for age and sex for asthma, diabetes, and epilepsy to socioeconomic population characteristics and to the supply of secondary care resources. SETTING: 90 family health services authorities in England, 1989-90 to 1994-5. RESULTS: At health authority level socioeconomic characteristics, health status, and secondary care supply factors explained 45% of the variation in admission rates for asthma, 33% for diabetes, and 55% for epilepsy. When health authorities were ranked, only four of the 10 with the highest age-sex standardised admission rates for asthma in 1994-5 remained in the top 10 when allowance was made for socioeconomic characteristics, health status, and secondary care supply factors. There was also substantial year to year variation in the rates. CONCLUSION: Health outcomes should relate to crude rates of adverse events in the population. These give the best indication of the size of a health problem. Performance indicators, however, should relate to those aspects of care which can be altered by the staff whose performance is being measured.

Age Distribution↗
PubMed1999

Is follow up by specialists routinely needed after elective surgery? A controlled trial.

STUDY OBJECTIVE: To assess the benefit of planned specialist follow up appointments after elective inpatient surgery. DESIGN: This was a controlled trial, using repeated alternate allocation of time periods to the two study groups. Group 1: Planned outpatient follow up 6-12 weeks after surgery. Group 2: No planned follow up: additional written information for patients and general practitioners. SETTING: A district general hospital in the north west of England. PARTICIPANTS: 264 patients listed for one of: transurethral resection of the prostate, varicose vein surgery, cholecystectomy (open or laparoscopic), inguinal herniorraphy (open or laparoscopic). MAIN OUTCOME MEASURES: Health status, complications, return to normal activity, patient satisfaction, use and costs of primary and secondary care in the 12 weeks after surgery. MAIN RESULTS: Data were available for 212 (80%) of eligible patients. Thirty eight per cent of patients in the "no planned follow up" group were in fact seen in outpatients after their discharge. Intention to treat analysis showed that there were no significant differences between the groups for health status, complications, or time to return to normal activity. Patients in the "no planned follow up" group had significantly fewer hospital visits and costs (mean difference in visits 0.51, 95% confidence intervals 0.39 to 0.69; mean difference in hospital costs 12.75 Pounds, 9.75 Pounds to 15.50 Pounds). There were fewer primary care staff contacts and costs in the "no planned follow up" group, although this difference was not significant (mean difference = 0.61 visits, -0.13 to 1.33 visits; primary care costs difference 8.37 Pounds, -1.31 Pounds to 18.73 Pounds). Patients in the "no planned follow up group" had significantly reduced patient travel costs (mean difference 4.84 Pounds, 3.44 Pounds to 6.22 Pounds). Eighty nine (42%) patients would prefer to be followed up by both their hospital doctor and GP; 53 (25%) patients would prefer to be followed up by the hospital doctor only. There were no significant differences between the two groups in their preferences for follow up. The majority of GPs agreed with the statement that a policy of no follow up at hospital outpatients for each of the six surgical procedures would increase their workload. CONCLUSIONS: Planned outpatient appointments after uncomplicated surgery seem to be neither necessary nor cost effective. A policy of "no planned follow up" results in no increase in primary care costs, and savings in hospital and patient costs. However, many patients expected and wanted to be seen again by their surgeon and GPs were concerned that a "no follow up" policy would result in an increase in workload.

Adolescent↗
PubMed1999

Clinical governance: bridging the gap between managerial and clinical approaches to quality of care.

Clinical governance has been introduced as a new approach to quality improvement in the UK national health service. This article maps clinical governance against a discussion of the four main approaches to measuring and improving quality of care: quality assessment, quality assurance, clinical audit, and quality improvement (including continuous quality improvement). Quality assessment underpins each approach. Whereas clinical audit has, in general, been professionally led, managers have driven quality improvement initiatives. Quality assurance approaches have been perceived to be externally driven by managers or to involve professional inspection. It is discussed how clinical governance seeks to bridge these approaches. Clinical governance allows clinicians in the UK to lead a comprehensive strategy to improve quality within provider organisations, although with an expectation of greatly increased external accountability. Clinical governance aims to bring together managerial, organisational, and clinical approaches to improving quality of care. If successful, it will define a new type of professionalism for the next century. Failure by the professions to seize the opportunity is likely to result in increasingly detailed external control of clinical activity in the UK, as has occurred in some other countries.

Health Care Reform↗
PubMed1999

The use of combination antiretroviral therapy in HIV-infected patients.

OBJECTIVE: To review the published clinical trials of combination antiretroviral therapy, current guidelines about the use of combination antiretroviral therapy, information regarding the impact of adherence on treatment effect, and the effects of combination antiretroviral therapy on morbidity and mortality. METHODS: A MEDLINE search (January 1986-March 1998) was performed to identify all relevant articles. Selected articles and abstracts from this time period and references from these selections were included for review. DISCUSSION: Nucleoside analog monotherapy treatment of HIV infection is inferior to treatment with multiple antiretroviral agents. With the availability of new classes of medications (protease inhibitors, nonnucleoside reverse transcriptase inhibitors [NNRTIs], and new nucleoside analogs, combination antiretroviral therapy is now more potent and more complex than ever. The use and effects of protease inhibitors in combination with nucleoside analogs has been well documented. The use of NNRTIs and combination protease inhibitor regimens are not as well documented but may prove to be at least as efficacious as single protease inhibitor-containing regimens. Increases in CD4+ cell counts of >100 cells/mm3 and decreases in HIV RNA (viral load) of >2 log are common with these medications, with antiretroviral naive patients being more likely to have substantial responses to therapy than experienced patients. CONCLUSIONS: Combination antiretroviral therapy in HIV-infected patients is now the standard of care. Combination antiretroviral regimens have been shown to reduce, at least temporarily, the morbidity and mortality associated with HIV infection and AIDS. However, these regimens are quite complex for patients to adhere to successfully. While the true long-term effects of combination antiretroviral therapy are unknown, their current effects on the HIV epidemic are unquestionable.

Anti-HIV Agents↗