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Biomedical subjects

M Rizzardini

Publications and source records attributed to M Rizzardini.

47 records · Page 3Linked to original sources
PubMedDate not supplied

[Maternal lactation. I. Resistance of maternal milk to bacterial contamination].

Bacteriologic studies in hands, nipples and milk in 10 wet-nurses were done in order to establish regulation for the recollection of breast milk to be used in low -birth-weight infants. The same studies were done in the hands of 10 nurse-aids, that help in the recollection of breast milk. The results depicts that the breast milk has bacteriostatic and bactericidal properties enough to protect against contamination by germs of the mother's bacterial flora. It does not have the same property against germs that are not of their own flora: those of the nurse-aids's hands. The protection is such that is possible to maintain the breast milk at environmental temperature of 4 degrees C, for 72 hours, without having the developing of germs not isolated previously, and even with the disappearance of some strains present in the initial cultures.

Asepsis↗
PubMedDate not supplied

[Maternal lactation. II. Intestinal colonization in breast fed newborn infants].

Twenty-three low birth weight infants were studied to establish the role that breast milk plays in the intestinal colonization of the preterm infant, and in the control of epidemic diarrhea due to enteropathogenic E. coli, in nurseries. Twelve of these case were fed breast milk in bottles, and eleven with "humanized" powder cow's milk (NAN M.R.). Bacteriologic studies of feces were performed daily during the first 18 days of life. In 5 cases given breast milk, and in 8 receiving cow's milk, Staphylococcus aureus was isolated. Enteropathogenic E. coli was found in 3 cases with breast milk and in 6 with cow's milk. The finding of other non-pathogenic strains, was similar for both groups, except in the case of Proteus, that was found in 10 cases with breast milk, and in only 3 cases with cow's milk. Breast milk was unable to avoid the colonization by E. coli and in one case, was unable to eradicate this germ. None of the cases fed breast milk had diarrhea, including the three cases with E. coli. In another group, 4 cases developed severe acute diarrhea, due to enteropathogenic E. coli followed by 2 deaths. The results seem to point out that although colonization by enteropathogenic strains of E. coli is not completely avoided, these strains do not cause disease when these infants are fed breast milk.

Asepsis↗
PubMedDate not supplied

[Study of fetal malnutrition. IV. Acid-base equilibrium in normal and in intrauterine-growth-deficient newborn infants].

Acid-base equilibrium parameters were studied in 11 full-term newborns with adequate weights for their gestational age and in 10 with deficit in their intrauterine growth, during the first 72 hours of life. Significant differences were found. Apparently, malnourished subjects who overcome chronic asphyxia are able to compensate the metabolic disturbances brought about through hyperventilation. The low figures of PaO2 found in babies show they will need higher concentration of oxygen in the air they inhale.

Acid-Base Equilibrium↗
PubMedDate not supplied

Possible relevance of N-trifluoroacetyladriamycin (AD 41) in the antitumoral activity of N-trifluoroacetyladriamycin-14-valerate (AD 32) in tumor-bearing mice. I. Pharmacokinetic evidence.

N-Trifluoroacetyladriamycin-14-valerate (AD 32) is an analog of doxorubicin whose chemico-physical characteristics are nontypical compared to the parent compound. Its most interesting feature is the lack of capacity to intercalate with DNA; thus, its mechanism of action as an antitumoral drug is still unknown. The N-trifluoroacetyl bond on the glycoside moiety is very stable and does not easily undergo enzymatic hydrolysis. Conversely, the valerate ester is split very rapidly by tissue and blood hydrolases. In this paper we present a kinetic study on AD 32, and we additionally follow the formation and disappearance of its metabolite, N-trifluoroacetyladriamycin (AD 41). Peak levels, areas under the curve, and beta-half-lives of AD 32 and AD 41 after an iv injection of 80 mg/kg of AD 32 to Lewis lung carcinoma-bearing mice are presented. The results indicated very rapid disappearance of AD 32 from blood and tissues, whereas AD 42 persisted for much longer. Moreover, all of the tissues taken into consideration were able to hydrolyze AD 32 to AD 41, suggesting that this compound plays an important role in the antitumoral activity of AD 32.

Animals↗