Search PubMed⌕ Search

Biomedical subjects

M Rigby

Publications and source records attributed to M Rigby.

At least 37 records · Page 2Linked to original sources

Health informatics as a tool to improve quality in non-acute care--new opportunities and a matching need for a new evaluation paradigm.

Whilst most health care is delivered to people living at home, the focus of innovation in health informatics concepts has been largely on acute hospitals. However, delivery of services in community settings, and often related to long-term conditions, is complex, and involves multiple professions and agencies, delivery of care in several locations including home settings, and individually tailored care for episodes lasting over long periods of time. This challenge is poorly supported by current information systems. However, computer-based record systems have a major potential to improve quality of care by enabling integrated care delivery through multi-professional electronic patient records, whilst also providing quality assurance processes. In turn, though, this requires a new evaluation paradigm. Firstly, the multi-disciplinary and holistic ideal of integrated care requires an as yet inadequately developed framework to give structure to assessment of the value and utility of the data recorded and the way in which they are processed and presented, mapped to clinical processes and to the views of consumers as prime stakeholders. Secondly, a deeper and longer-term evaluation philosophy is needed which does not stop after the initial confirmation of system functioning, but continues on with a deepening into the effects on the individual clinical services, and then on the host user organisation. This paper maps out the new paradigm, and suggests specific issues which merit practical research to reset evaluation and assessment tools to this new setting and viewpoints.

Ambulatory Care↗

Considerations on the quality of medical software and information services.

Fast developments in information and communication technology have made it possible to develop new services for citizens. One of the most interesting areas is health care. Medical knowledge is usually valid all over the world that makes the market global. Information services and decision support software are becoming important tools for medical professionals but also ordinary citizens are interested in health related information. It has been estimated that by the year 2010 the turnover of health care telematics industry may be close to that of the drug industry today. The nature of this global information industry is very different from any industry in history. Since there are no frontiers, no clear products and no shops in the information market, it is difficult to develop any effective legislation. However, the history of medicine has shown that health care sector cannot be free from regulation without risking citizens' health. The huge commercial potential of the Internet has already been used to promote products and services that have no proven effect on health and that may sometimes be even dangerous. In this paper we discuss the needs and possibilities to assess the quality of medical decision support software and information services. For brevity the terms medical software and medical knowledge are used, but the issues also relate to informatics systems used by any health professional, and to computerised systems used to schedule care or to organise record systems.

Decision Support Systems, Clinical↗

Finding ethical principles and practical guidelines for the controlled flow of patient data.

The application of computing to health care, and particularly to electronic patient records, offers major benefits but raises issues of confidentiality and of potential misuse. Sound access control mechanisms are therefore important, but most models focus upon informed consent by the data subject. This raises challenges in mental health care, and for other vulnerable patients including those comatose, and the severely ill and temporarily distressed. Published algorithms which are used to control record access within a controlled environment therefore have value, as a means of ensuring an open and informed, yet ethically sound, solution. The paper describes the background and issues, and gives an example of such an algorithm.

Computer Security↗

The importance of developing an informatics framework for mental health.

Though mental health services are important in human terms, and account for a tenth of health expenditure, they are not well served in informatics developments. There are no specific mental health components in the European Union's health telematics programmes, and there is similar under-representation in national programmes. Yet telematics has much to offer mental health services and their management, and can address directly current service anxieties. Telematics concepts which could benefit mental health include integrated, multi-disciplinary records, real-time multi-site record access, and structured programmes to plan, schedule, and monitor care delivery. The power of information systems to sort data, and to represent them graphically, can sift like data items from complex records, and can present them in displays which highlight their significance. Above all, quality of care can be enhanced by monitoring, and by improved outcome measurement. However, a planned programme of research and development is needed, to relate and adjust current health informatics techniques to the special attributes of mental health. The World Health Organisation has identified the potential of such a programme, but greater vision and commitment is needed at policy level if mental health services and patients are to receive the benefits from health informatics which are available to the physically ill.

Abstracting and Indexing↗

The need for a holistic view of telemedicine, focused on patients and society as prime stakeholders.

Telemedicine provides the scope to remove the barrier of distance from delivery of health care. In so doing it has the potential to strengthen primary care and local health delivery, and to optimise the use of secondary and tertiary specialist resources. However, it can have disbenefits and perverse effects which are as yet inadequately addressed. Development of telemedicine to date has been led by new technological opportunities, linked to clinical interests. Whilst not inappropriate, this alone is not adequate. All health care activities should be to promote health and treat ill-health, and therefore the interests of the consumer and of society should predominate. More complete research and policy analysis of telemedicine are therefore needed. This paper argues for a more holistic and integrated view of telemedicine to be taken, to ensure that technology is harnessed to meet need. To this end, it puts telemedicine into the overall context of health care interests, and describes methodologies to assess patient attitudes and societal priorities. Given the need to avoid the unanticipated adverse effects which have bedevilled other new health care technologies, and the particular risks of uncontrolled consultations and commerce across national boundaries, the paper goes on to advocate routine use of integrated risk analysis of telemedicine applications at research and policy levels. The need for an effects-orientated analytic framework, and for international policy collaboration to protect users of services available by global telecommunications, is identified.

Health Policy↗

The ethical imperative of child health population-based data a top-down/under-up analysis from the United Kingdom and Australia.

The policy move in both the United Kingdom and Australia to competitive primary care child health services (including preventive services and surveillance) has many advantages, but without secure and epidemiological information systems has the potential to put children at risk. More fundamentally, it produces the perverse effect of operating directly in opposition to the desirable policies of audit, outcomes studies, and evidence-based health care. Moreover, generations of children stand to be disadvantaged if environmental and ecological risk factors, as well as adverse clinical outcomes, cannot be identified quickly. Health informatics, linked to professional duties of clinical and fiduciary accountability, provide a way out of this conundrum. Standard clinical data sets, linked to invoicing procedures, would enable the development of summary records which could underpin integrated surveillance whilst also fuelling the new public health. Appropriate professional supervision, confidentiality and security measures, and agreement of data sets, would be necessary but not difficult in informatics terms. As health policy and delivery move forward, it is important not to lose the best aspects of previous systems and opportunities of future technologies.

Australia↗

Towards an ethical protocol in mental health informatics.

Application of informatics to mental health has the potential to benefit a disadvantaged yet important patient group. At the same time, difficult issues are raised with regard to data protection and ethics because many patients are not able to express informed and rational views, and this increases their vulnerability. However, developments in this field are limited, and there is little literature. Generic data protection legislation and guidance assumes that data subjects are mentally competent adults. This paper distils key ethical issues and principles in mental health informatics, and describes a process which has initiated the identification of "reasonable" practice.

Adult↗

Establishing the feasibility of cross-mapping independent child health data sets as a means of comparing health status and service quality.

Benefits of comparative data analysis for quality assurance and policy development are clear, but are difficult to establish through traditional means of prospective projects. This paper describes a pilot project to test an alternative method, namely seeking to identify areas of commonality amongst very different pre-existing data sets to provide a starting point. Advantages and disadvantages of this method, together with the critical factors identified in the pilot study, are described. Whilst developed in child health, the lessons learned are relevant for any other client groups.

Austria↗

[Coil embolization of persistent ductus arteriosus].

From September 1994 to January 1996, 57 patients were admitted to Brompton Hospital for catheter closure of persistent ductus arteriosus. Umbrella closure was attempted in 22 patients and coil closure in 35. The duct was closed by a device in 55 of 57 patients (96.4%). Two patients were referred for surgical closure, one after failure of the umbrella closure and one after coil embolization to a branch of the pulmonary artery. Two additional coils embolized to pulmonary artery branches. Both coils were successfully retrieved by a snare, and the procedure then finished successfully. We recommend the use of coils for closure of small ducts, and for residual leak after previous umbrella closure. This is also a promising method for closure of larger ducts.

Adolescent↗

Synovial sarcoma of the heart.

Primary synovial sarcomas of the heart are exceptionally rare tumours, only five being previously documented. We report a sixth case and review published data. Ages ranged from 13-53 (mean 40.8) years. There were four men and two women who characteristically presented with syncope or dyspnoea. Most of the tumours arose in the right atrium where they formed pedunculated or polypoid masses. In the previously documented cases, all patients died within 9 months. However in our case, local excision was felt to have been complete and the patient remains disease free at 10 months.

Adolescent↗

Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity.

We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Based on NH2OH sensitivity, it appeared that the ADP-ribose was attached to arginine residues on proteins. We also observed that the NAD+ concentration in culture medium correlates inversely with the proliferation of rat RT6+ T cells. The data suggest that lymphocyte surface ADP-ribosyltransferases could be involved in signaling and immunoregulatory processes.

ADP Ribose Transferases↗

L-733,060, a novel tachykinin NK1 receptor antagonist; effects in [Ca2+]i mobilisation, cardiovascular and dural extravasation assays.

This study investigated the properties of a novel piperidine ether-based tachykinin NK1 receptor antagonist L-733,060, ((2S,3S)-3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenyl piperidine and its 2R,3R-enantiomer L-733,061 on [Ca2+]i mobilisation in Chinese hamster ovary cells transfected with human tachykinin NK1 receptors, compared to their effects in rodent cardiovascular and neurogenic plasma extravasation assays. Using FURA-2-imaging techniques, L-733,060 inhibited substance P-induced [Ca2+]i mobilisation with an estimated affinity of 0.8 nM whereas L-733,061 (30-300 nM) did not. No significant effects of L-733,060 were observed on mean arterial blood pressure or heart rate in conscious or anaesthetised rats at doses of < 3000 micrograms kg-1 i.v. L-733,060 also stereoselectively inhibited neurogenic plasma extravasation in rat dura produced by electrical stimulation of trigeminal nerves with an ID50 of 212 +/- 19 micrograms kg-1 i.v. Thus, L-733,060 is a novel antagonist of human tachykinin NK1 receptors which stereoselectively inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects.

Animals↗

A receptor in pituitary and hypothalamus that functions in growth hormone release.

Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

Amino Acid Sequence↗