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M Riedel

Publications and source records attributed to M Riedel.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Insect stings].

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Animals↗
PubMed1986

Sellar lesions associated with isolated hyperprolactinaemia. Morphological, immunocytochemical, hormonal and clinical results.

In 204 patients with sellar lesions and isolated hyperprolactinaemia we analysed and compared many different morphological, immunocytochemical, hormonal, and clinical data for a differentiation of primary (Prl produced by a tumour) and secondary (Prl elevation by PIF inhibition) hyperprolactinaemia. We found Prl-positive pituitary adenomas with primary hyperprolactinaemia in 62.7% and a secondary Prl elevation with different alterations in 37.3% (Prl-negative adenomas 28.9%, craniopharyngeomas 5%, and non-tumourous conditions 3.4%). In secondary hyperprolactinaemia the Prl values did not exceed 130 micrograms/l, higher levels indicated Prl-producing adenomas with a high probability. In patients with Prl elevation below 130 micrograms/l the clinical and sometimes the morphological analysis were not sufficient for a differentiation. Here immunocytochemical studies are necessary for a clear classification of hyperprolactinaemia.

Adenoma↗
PubMed1985

Grading of pituitary adenomas in acromegaly. Comparison of light microscopical, immunocytochemical, and clinical data.

In a series of 284 adenomas from cases of acromegaly we studied major morphological variables using light microscopical techniques and compared them with immunocytochemical and clinical results. Using our semiquantitative estimations many inter-relationships were observed. We established the density of secretory granules, nuclear pleomorphism and the rate of occurrence of multinuclear tumour cells, as essential features of tumour differentiation. Mitotic activity and invasive growth patterns did not reveal clear dependences. Immunocytochemical analysis of 105 cases showed growth hormone (GH) in nearly all adenomas (98%), prolactin in 68%, and LH in 40%. The other hormones (ACTH, FSH, and TSH) were present at a much lower rate. Monohormonal GH-adenomas were found in only 29% of our cases. Many different combinations of hormone content could be demonstrated without any relationship to morphological or clinical data. From the linear correlations and advanced method of semiquantitative evaluation, the granular density of the tumour cells is the most useful variable for subclassification and grading of pituitary adenomas in acromegaly.

Acromegaly↗
PubMed1983

Primary varicose veins and HLA.

138 patients with primary varices of the lower extremities were typed in two independent studies for 41 HLA antigens A, B, C, and their frequencies were compared to those in controls. In both studies, the patients showed higher frequency of HLA-B7 (36.2 vs. 23.4%, relative risk 1.86, p = 0.0013) and lower frequencies of HLA-Aw19 (9.4 vs. 25.0%, relative risk 0.312, p = 0.00006), Cw5 (0.7 vs. 9.8%, relative risk 0.067, p = 0.0001) and Cw6 (7.3 vs. 27.0%, relative risk 0.212, p = 0.00003). These differences were most pronounced in patients whose fathers also suffered from primary varices. No relationship was found between HLA antigens and the sex of the patients or the age at the onset of varices.

Adult↗
PubMed1982

Longterm follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data.

Seventy-six patients with various forms of pulmonary thromboembolic disease were followed-up for 1 to 15 years. All were free of other cardiopulmonary disease at the time of the first examination which was performed at least two months after the last pulmonary embolism. Catheterization was repeated in all survivors on average 4.8 years later. Severe chronic pulmonary hypertension (mean pulmonary artery pressure (PPA greater than 30 mm Hg) did not occur after a single episode of acute embolism, was infrequent after single subacute or recurrent emboli (8 of 9 patients), and was common after occult emboli (12 of 13 patients). Mortality in all clinical groups correlated with PPA and with the presence of right heart failure. In survivors, no correlation was found between the longterm changes of PPA and age, duration of disease, interval between catheterizations, PaO2, or cardiac output. Pulmonary hypertension progressed further in patients with initial PPA greater than 30 mm Hg. In contrast, none of the patients with normal or borderline PPA at the initial examination developed severe pulmonary hypertension during the follow-up. Since the future course of patients could be predicted from the first examination, repeated hemodynamic investigation proved to be of minor prognostic value.

Adult↗
PubMed1981

The biological effect of very high energy hadrons.

The meristems of Vicia faba bean roots were irradiated at different depths in water in a 250 GeV/c positive hadron beam from the CERN Super Proton Synchrotron (SPS). The growth during the 10 days following irradiation was determined and compared with results obtained from 60Co gamma-ray exposures. The data indicate a Relative Biological Efficiency (r.b.e.) near to one, independent of the contribution of secondaries to the dose. However, some anomalies in the radiation response of the irradiated beans were noted.

Cobalt Radioisotopes↗