Search PubMed⌕ Search

Biomedical subjects

M Richardson

Publications and source records attributed to M Richardson.

At least 235 records · Page 13Linked to original sources
PubMed1993

Digitized doctoring. A healthy mix of medicine and computers.

Computers, these days, are almost smaller than a bread box. They sit unobtrusively atop a desk, silently awaiting the next command. And yet, for such a small package, these microelectronic-based, information-processing devices have profoundly affected mankind in the second half of the 20th century. Computer technology has radically altered how -- and how fast -- the world changes.

Computers↗
PubMed1993

Catabolism of unglycated and naturally glycated forms of rabbit fibrinogen: their interaction with the healthy and deendothelialized aorta wall in normal and diabetic rabbits.

The incidence of nonenzymatic glycation of proteins within the hyperglycemic environment of diabetic plasma is increased compared with that in normal (i.e., nondiabetic) plasma. Whether glycation in vivo alters the behavior of proteins within the circulation is not well understood. Glycated fibrinogen, although not detected in normal rabbit plasma, was isolated from diabetic rabbit plasmas (glucose concentration 12 to 39 mmol/L) and separated from unglycated fibrinogen by boronate chromatography. The yield of glycated fibrinogen, which amounted to 3% to 6% of total fibrinogen, correlated with the content of plasma glucose. Glycated and unglycated fibrinogens facilitated aggregation of normal or diabetic platelets to a similar extent after adding adenosine-5'-diphosphate. Normal platelets stimulated by adenosine-5'-diphosphate bound more iodine 131-glycated fibrinogen than iodine 125-unglycated fibrinogen (p < 0.05), whereas the quantities of glycated and unglycated fibrinogens bound by diabetic platelets were not significantly different. When coinjected intravenously into normal or diabetic rabbits, 131I-glycated fibrinogen was cleared from the circulation faster than 125I-unglycated fibrinogen although the catabolic rates, measured as half-life, were not significantly different. At equilibrium, glycated fibrinogen was distributed significantly more in the extravascular and less in the vascular compartments of the normal and diabetic rabbit compared with the unglycated type. After balloon injury to the aorta in vivo, the unglycated/glycated ratio of radiolabeled fibrinogens associated with the platelet monolayer was 0.94, whereas for the damaged subendothelium the ratio was 1.20 (p < 0.005). We conclude that glycation in vivo changes several metabolic characteristics of fibrinogen in the normal and diabetic rabbit.

Animals↗
PubMed1993

It's all relative. For many, the medical profession is a family affair.

Call up some households and ask, "Is there a doctor in the house?" and you may hear, "Which one do you want?" In a host of Texas families, the medical profession represents a long-standing tradition. Typically, a daughter or son follows in the footsteps of a successful parent. But in some families, the line of physicians goes back several generations and includes many branches of the family tree. A few months back, Texas Medicine invited physicians who come from medical "dynasties" to contact us about their experiences. We received an amazing array of letters, faxes, and phone calls from scores of doctors who have either two or more generations of physicians or several doctor siblings in their families. What they told us about their families was even more fascinating.

Career Choice↗