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Biomedical subjects

M Reznik

Publications and source records attributed to M Reznik.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Ultrastructural modifications of the bladder wall in senescence].

Histochemical and ultrastructural studies of the epithelial, muscular, connective, vascular and nervous tissue layers have been carried on endoscopic or surgical biopsies in patients from 23 to 92 years old. Beyond 70 years old, the junctional complexes between the superficial cells of the epithelium are altered and the number of intracellular organelles is diminished. The intercellular spaces and binds between the muscle cells are modified. Some interstitial fibrosis occurs and the density of the connective tissue increases. The authors describe also similar observation in the bladder wall of the old rats. An arteriosclerosis of small vessels is observed. The density of the autonomous nervous network is reduced and the cholinergic innervation becomes preponderant. No specific ultrastructural modification of the nerves is seen except a neuromuscular infiltration by a conjunctive hyperplastic tissue. These morphological changes can be related to some modifications of the vesical compliance.

Adult↗
PubMed1989

Myositis during Borrelia burgdorferi infection (Lyme disease).

During the second stage of an illness caused by Borrelia burgdorferi, a young woman developed a myopathic syndrome characterised by severe muscular pains, incapacitating weakness of the proximal limb and the neck, as well as the bulbar muscles and elevated serum CK levels. Muscle biopsy revealed a non-inflammatory necrotising myopathy. B. burgdorferi infection was confirmed by a considerable rise of specific IgG antibodies. A course of high dose steroids alleviated the myalgias, but paresis began to improve only after treatment with antibiotics. Our observations confirm that B burgdorferi can cause, through an undertermined mechanism, a necrotising myopathy, in addition to the wide spectrum of already known neurological complications.

Adult↗
PubMed1988

Clinical and radiological aspects of dysplastic gangliocytoma (Lhermitte-Duclos disease): a report of two cases with review of the literature.

Two cases of Lhermitte-Duclos disease confirmed by biopsy are reported. Review of the 58 published cases shows that the disease can manifest itself only by signs of increased intracranial pressure. Cerebellar symptoms are not constant. Computed tomographic (CT) scans suggest the diagnosis by showing a posterior fossa lesion, iso- and hypodense, partially calcified, and not enhanced by contrast medium. Magnetic resonance imaging (MRI) seems to define limits of the lesion better than CT scanning and could improve the surgical approach. Surgical excision of the lesion is the only satisfactory treatment. The postoperative prognosis is usually favorable.

Adult↗
PubMed1988

Mammosomatotropes in human pituitary adenomas as revealed by electron microscopic double gold immunostaining method.

Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients.

Adenoma↗
PubMed1987

[Paraneoplastic limbic encephalopathy, inappropriate ADH secretion and recurrent subclinical epileptic seizures. Clinical, anatomo-pathological and metabolic correlations by positron emission tomography].

We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed diabetes mellitus and a syndrome of inappropriate antidiuretic hormone secretion (IADH). Haemodynamic and metabolic studies by positron-emission tomography showed an important increase in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen on the left anterior temporal region precisely where the electrical seizures were recorded. Nine months later, severe disorders of memory and a dramatic decrease in CBF and CMRO2 on the same area region were present. At autopsy, a small size oat cell bronchial carcinoma was found with metastases in two small adjacent lymph nodes. Neuropathological examination showed atrophy (neuronal loss, protoplasmic gliosis) in the amygdala; where there was in addition an area of nodular gliosis. The hippocampus and parahippocampal gyrus lesions were severe on the left and moderate on the right side. The authors discuss the nosology of their case in the paraneoplastic syndromes and, with a review of the literature, the role of ADH and cellular hyperactivity in the pathogenesis of specifically localized neuronal alterations.

Amnesia↗
PubMed1987

[Neuroendocrine tumor of the nasal cavity (esthesioneuroblastoma). Apropos of a case with paraneoplastic Cushing's syndrome].

Presentation of a 48-y old woman who developed a neuroendocrine tumor of the nasal cavities. This lesion progressed rapidly despite an extensive resection and repeated chemotherapy. The patient refused radiotherapy. Before her death, 28 months later, she exhibited a paraneoplastic Cushing-like syndrome. At autopsy, restricted to the brain, there was a 5 cm diameter tumor invading the frontal area without alteration of the hypothalamus or the pituitary gland. Routine histology and electron microscopy confirmed the neuroendocrine nature of the tumor. Immunohistochemistry revealed the tumor to be positive only for neurone specific enolase, negative for S-100 protein, neurofilament and ACTH. The pituitary gland was positive for most usual hormones (GH, PRL, TSH, LH, FSH) but only few cells were slightly positive for ACTH. Many Crooke cells were observed. These findings suggest that the tumor secreted an ACTH-like substance (not detected actually by immunochemistry) that stimulated the activity of the adrenal cortex but inhibited normal production of ACTH at the pituitary gland level.

ACTH Syndrome, Ectopic↗
PubMed1986

Central dopaminergic and noradrenergic receptor blockade in a patient with neuroleptic malignant syndrome.

During treatment with clomipramine and haloperidol, a 54-year-old depressed woman exhibited a typical neuroleptic malignant syndrome (NMS). Among results of biologic tests performed at least 2 weeks after discontinuation of all psychotropic treatment, the absence of normal growth hormone response after both apomorphine and clonidine challenge tests and increased levels of cerebrospinal fluid homovanillic acid and urinary 3-methoxy-4-hydroxyphenylglycol suggest that NMS may be related to central dopaminergic and possible alpha-noradrenergic receptor blockade.

Clomipramine↗
PubMed1986

[Choroid plexus papilloma of the cerebellopontine angle. Presentation of a case and review of the literature].

Choroid plexus papillomas of the cerebellopontine angle are quite rare. Up to date, 19 cases surgically removed have been reported (table I). We describe the case of a 25 year old man with a choroid plexus papilloma (C.P.P.) who presented only two syncopes in the interval of 4 months. A computed tomographic scan revealed a calcified right extra-axial tumor occupying the cerebellopontine angle and a moderate degree of obstructive hydrocephalus. A vertebral angiogram showed that the tumor was avascular. A right suboccipital craniectomy was performed and the mass was excised in totality. The patient was discharged from hospital 2 weeks after surgery. 10 months later, neurological findings were normal. Histological examination exhibited a typical papilloma of the choroid plexus. The differential diagnosis of tumors in the C.P.P. angle is discussed. Total surgical excision in the treatment of choice. Radiation therapy could be used when the resection is incomplete.

Adult↗