Biomedical subjects

M Renis

Publications and source records attributed to M Renis.

44 records · Page 3Linked to original sources

PubMed1977

MAO activity in rat brain stem and cerebral cortex following acute and chronic treatment with L-dopa and ethanol + L-dopa.

This work reports the effects of acute and chronic administration of L-dopa and ethanol + L-dopa on MAO activity in rat brain stem and cerebral cortex using noradrenaline (NA), dopamine (DA), serotonin (5-HT) and tryptamine (Try) as substrates. The results obtained clearly demonstrate that acute and chronic treatment affects MAO activities in the two brain areas examined in opposite ways. Moreover, the two treatments show different effects both according to the substrate used, and, especially in the case of NA and Try, according to the brain area examined.

Animals↗

PubMed1976

In vivo and in vitro studies on the effect of tetrahydropapaveroline and salsolinol on COMT and MAO activity in rat brain.

Studies were made on COMT and MAO activity in rats 2, 4, 6, 12 and 24 h after intraperitoneal treatment with 8 and 60 mg/kg doses of tetrahydropapaveroline (THP), and 10 and 20 days after treatment with 8 mg/kg/day. Results suggested COMT activity inhibition only after 2 h of treatment. Experiments were also performed on THP and salsolinol methylation capacity in vitro. Results showed that both alkaloids use COMT enzymes for methylation and can also act as competitive inhibitors of COMT and MAO activity.

Alkaloids↗

PubMed1975