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Biomedical subjects

M Renard

Publications and source records attributed to M Renard.

168 records · Page 10Linked to original sources
PubMedDate not supplied

Effect of labetalol on preload in acute myocardial infarction with systemic hypertension.

We assessed the effects of labetalol on pulmonary wedge pressure (PWP) and other hemodynamic variables in 18 patients with acute myocardial infarction (AMI) and systemic hypertension (systolic blood pressure greater than 150 mm Hg). According to the initial value of PWP, the patients were separated into two groups of nine patients each: Group 1 (PWP greater than or equal to 15 mm Hg) and Group 2 (PWP less than or equal to 12 mm Hg). Labetalol was infused at increasing rates to lower systolic blood pressure below 130 mm Hg; this optimal rate (mean rates for Groups 1 and 2: 1.8 and 2.1 mg/min, respectively) was maintained for 1 h. Hemodynamic variables were measured before and after 1 h of infusion. Labetalol normalized blood pressure in both groups by a significant decrease in total systemic resistance [22% (p less than 0.001) and 13% (p less than 0.02)] and in cardiac index [17% (p less than 0.005) and 12% (p less than 0.02)]. While the hemodynamic responses were rather similar in both groups, the PWP decreased significantly (from 22 to 15 mm Hg, p less than 0.01) in Group 1, but did not change significantly in Group 2 (from 7 to 10 mm Hg, NS). The possible mechanisms behind these different responses are discussed. We conclude that labetalol is an effective drug for treating systemic hypertension in AMI which acutely decreases total systemic resistance and preload in patients with moderate left ventricular failure.

Adult↗
PubMedDate not supplied

[Sulmazole: a new positive inotropic agent].

Sulmazol (AR-L 115 BS) is a new positive inotropic agent with arterial and venous vasodilator properties. The authors studied the effects of a 24 hours intravenous infusion (an injection of 0.5 mg/kg over 1 minute, followed by an infusion of 1.4 mg/min) on the major haemodynamic parameters of 17 patients with heart failure: 10 patients with chronic decompensation (group I) and 7 patients with heart failure as a result of acute myocardial infraction (group II). The haemodynamic criteria of inclusion were a cardiac index less than or equal to 2.5 l/min/m2 and a pulmonary capillary pressure greater than or equal to 18 mm Hg. After 6 hr of the infusion, the cardiac index increased in both groups (45%, p less than 0.001 and 40%, p less than 0.001 respectively); the pulmonary capillary pressure decreased (32%, p less than 0.001 and 30%, p less than 0.001) and the right atrial pressure decreased (51%, p less than 0.005 and 31%, NS). The total systemic resistance was also decreased (32%, p less than 0.001 and 34%, p less than 0.001), but there was no significant change in the systolic blood pressure. The heart rate increased only in group II (17%, p less than 0.001). These beneficial hemodynamic effects lasted for the 24 hours of the infusion. Sulmazol was therefore found to be very effective in the treatment of acute and chronic heart failure; its long term tolerance still needs to be demonstrated.

Aged↗
PubMedDate not supplied

[Medical and surgical treatment of dilated and viral cardiomyopathies].

Treatment of cardiomyopathy has to take into account correction of etiology or improvement of aggravating factors. Management of cardiomyopathy is not basically different from treatment of classic heart failure. Some drug as amlodipine or miscellaneous beta-blockers might be more effective in cardiomyopathy. Heart transplantation remains the main surgical treatment of end stage cardiomyopathy while other procedures (cardiomyoplasty, ...) are still under assessment.

Amyloidosis↗
PubMedDate not supplied

[Treatment of cardiac insufficiency in the elderly].

The structural changes of the elderly's heart predispose to cardiac insufficiency. Treatment has to take into account the pharmacological aspects of aging which reduce drug tolerance. Success will be usually obtained after reducing preload in this type of diastolic heart failure.

Aged↗