Hand-clasping refers to the preferential tendency for individuals to clasp the hands together. This paper reviews the previous literature on family data and twins, and reports new data. In this study about 55% of the population are left-hand-claspers, 44% are right-hand-claspers, and the remaining 1% report that they have no preference or are indifferent. Familial data suggest that hand-clasping may be under genetic control: although the data do not fit any straightforward recessive or dominant Mendelian model, they are compatible with the type of model invoking fluctuating asymmetry which has been used to explain the inheritance of handedness and arm-folding. It is possible that hand-clasping, as for example arm-folding, may be an idiosyncrasy due to or influenced by physical bilateral differences in the hands. All data together are suggestive of a genetic basis, although environmental influences are also evident.

Adult↗

PubMedDate not supplied

Adjuvant sequential dose-dense doxorubicin, paclitaxel, and cyclophosphamide (ATC) for high-risk breast cancer is feasible in the community setting.

PURPOSE: This study evaluated the feasibility, when given in the community, of dose-dense, sequential ATC (doxorubicin, paclitaxel, cyclophosphamide) as adjuvant therapy for breast cancer with four or more metastatic axillary lymph nodes. PATIENTS AND METHODS: Patients were recruited after definitive breast cancer surgery if four or more axillary nodes were involved by metastatic cancer and if distant metastases were not present on computed tomographic scan or bone scan. Forty patients received doxorubicin, 90 mg/m2 every 14 days for three cycles; paclitaxel, 250 mg/m2 every 14 days for three cycles; and cyclophosphamide, 3 g/m2 every 14 days for three cycles with filgrastim support. Chemotherapy was administered by the referring physician. RESULTS: Mean dose intensity was 99% for doxorubicin, 96% for paclitaxel, and 99% for cyclophosphamide. Grade 3 toxicities included mucositis (13%), nausea/vomiting (10%), neuropathy (13%), and myalgia/arthralgia (10%). Thirteen patients had neutropenic fever. One patient developed acute leukemia. Three relapses have occurred. Ninety percent of patients are alive and disease-free at a median follow-up of 24 months. DISCUSSION: ATC can be administered in the community at full doses with acceptable toxicity. Preliminary efficacy data suggest that this high-dose, intensively scheduled regimen warrants comparison with standard therapy for high-risk patients.

Adult↗

PubMedDate not supplied

Tissue microarray: a new technology for amplification of tissue resources.

Tissue microarrays are a method of harvesting small disks of tissue from a range of standard histologic sections and placing them in an array on a recipient paraffin block such that hundreds of cases can be analyzed simultaneously. This technique allows maximization of tissue resources by analysis of small-core biop sies of blocks, rather than complete sections. Using this technology, a carefully planned array can be constructed with cases from pathology tissue block archives, such that a 20-year survival analysis can be performed on a cohort of 600 or more patients by use of only a few microliters of antibody in a single experiment. The reflex criticism of this technique is that the tissue analyzed is not representative, especially in antigens with heterogeneous staining patterns. This review addresses this issue, as well as the issue of antigen preservation or durability, which validates construction of arrays from archives. Strategies and methods of construction and analysis of the arrays are discussed, as well as some other unusual array applications. This technique can provide a highly efficient, high-throughput mechanism for evaluation of protein expression in large cohorts. It has the potential to allow validation of new genes at a speed comparable to the rapid rate of gene discovery afforded by DNA microarrays.

Antigens↗

PubMedDate not supplied

[Certain aspects of laterality research].

One-side dominance, known as morphological and functional asymmetry, in the limbs a human characteristic that is of genetic or of both genetic and environmental origin. There are several aspects investigating laterality in men. Altogether it is possible to distinguish morphological and functional asymmetries. A vast range of testing techniques have been used to assess handedness. Asymmetry in hand use takes two forms: differential hand preference and differential dexterity between the hands. Writing hand and self-report are two of the most popular techniques. Other preference measures include observation of how people use tools and questionnaires. Performance tests assess speed and accuracy in tasks stressing manipulative dexterity. Morphologic asymmetries are not so useful for the investigation of the handedness. This method should only be used in past mortem examinations. The literature on laterality is large, but there are only a few studies in the last years concerning the morphologic asymmetries compared to the studies on functional asymmetries.

Functional Laterality↗