[The ethics of disease and the nursing profession].
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Disease↗
Biomedical subjects
M Reichlin
Publications and source records attributed to M Reichlin.
The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases.
Seventy-two patients were studied whose sera contained antibodies to a cytoplasmic antigen, RO. The majority had clinical features typical of systemic lupus erythematosus and there appeared to be an overlap with Sjögren's syndrome. Of interest is that certain patients with lupus respond predominantly to cytoplasmic antigens and in some cases were ANA negative. Demonstration of this system is important in enlarging the serologic spectrum characteristic of SLE patients, and also may be an important marker for systemic disease in patients with predominantly cutaneous involvement.
Antibodies, Antinuclear↗
Development of the anti-ribosomal P autoantibody response.
OBJECTIVE: Autoantibodies to the ribosomal P phosphoproteins (anti-P) appear almost exclusively in SLE. The mechanism by which these autoantibodies appear is unknown. The aim of this study was to determine if IgM and IgG isotype switching occurs during the development of the anti-P autoantibody response. METHODS: Patients who acquired IgG anti-P during clinical observation had their serial serum samples from this period screened for IgM and IgG anti-P by immunoblots and ELISAs. Rabbits were immunized with the immunodominant peptide of the ribosomal P proteins ("P-peptide") cross-linked to bovine serum albumin. Their serial samples were also analyzed for IgM and IgG anti-P before and after repeated immunizations. RESULTS: Two patients were identified who developed transient low titer IgM anti-P that preceded the development of their IgG anti-P. Both patients were clinically well during their peak of IgM anti-P, and developed flares of disease coincident with their high titered IgG anti-P response. The "P-peptide"-immunized rabbits developed an IgM anti-P response that preceded IgG anti-P, and that decreased over time. CONCLUSION: We conclude that IgM to IgG isotype switching occurs in the anti-P autoimmune response. These findings suggest that the autoimmune response to the ribosomal P proteins may be antigen-driven.
Adult↗