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Biomedical subjects

M Reginster

Publications and source records attributed to M Reginster.

At least 37 records · Page 2Linked to original sources
PubMed1976

Preparation and characterization of influenza virus cores.

Lipid-free influenza virus cores have been obtained by a three step procedure consisting of (a) treatment with proteolytic enzyme, (b) fixation with formaldehyde and (c) delipidization with saponin or deoxycholate. Several reagents proved efficient in removing the virus lipids as judged by morphological features and increased buoyant density, but only cores prepared by means of sodium deoxycholate have been characterized closely. Ultrathin sections revealed round bodies (about 65 nm in diam.) delineated by a single dense track and with an internal structure very similar to that of the complete virus particles. They contained both the nucleoprotein and the M-protein and no lipids. It is proposed to call the limiting structure which appears (3 to 4 nm thick in ultrathin sections) the core shell.

Deoxycholic Acid↗
PubMed1976

[Passage into normal salivary, lacrimal and nasal secretions of ampicillin and erythromycin administered intramuscularly].

The authors have measured, with the agar diffusion technique, the antibiotic concentrations in the serum as well as in the normal nasal, lachrymal and salivary secretions, after an intramuscular injection of 500 mg of ampicillin and of 200 mg of erythromycin. Bacillus subtilis is used as test germ for dosage of ampicillin and Sarcina lutea for the dosage of erythromycin. An important quantity of ampicillin (0.5 to 2.5 microgram/ml) passes into the nasal secretion. Its passage into the saliva is very irregular and is usually very slight. Bacillus subtilis is not suitable for systematically studying the ampicillin concentration in the lachrymal secretion, which displays a strong, inherent inhibitory effect on this micro-organism. Important concentrations of erythromycin are found in the three secretions: 0.5 to 3.25 microgram/ml in the nasal mucus and in the lachrymal secretion, 0.3 to 4.5 microgram/ml in saliva.

Ampicillin↗