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Biomedical subjects

M Ray

Publications and source records attributed to M Ray.

267 records · Page 15Linked to original sources
PubMed1966

Mail-order chromosome analysis.

A simple but reliable technique has been developed for the mailing of plasma to chromosome laboratories for cytogenetic analysis. Cultures have been grown successfully from plasma which has been as long as four days in transit. Plasma is removed after heparinized whole blood has been left standing at room temperature for at least three hours. Phytohemagglutinin (0.1 ml. PHA/ml. plasma) and two to three drops of red cells are added to the plasma, and the specimen is immediately transmitted by air mail to the nearest cytogenetic laboratory. Sterile technique is used throughout.

Canada↗
PubMedDate not supplied

Fra(2) (q13) and inv(9) (p11q12) in autism: causal relationship?

Twenty individuals with autism or related disorders underwent chromosome analysis and physical examinations with documentation of minor anomalies. Chromosome anomalies were identified in 3: 2 had the heritable folate sensitive fra(2) (q13) site and 1 had an inv(9) (p11q12). No heritable chromosome variants or anomalies were seen in 20 age and sex-matched control individuals. When patients with the fra(2) were excluded from analyses, there was no difference in the frequency of chromosome breaks and/or gaps between the study group and control group. The results of this study suggest that heritable folate sensitive fragile sites and other chromosome variants may be more commonly seen in individuals with autism or related disorders in childhood than in the general population.

Adolescent↗
PubMedDate not supplied

Long term survival in a young girl with renal cell carcinoma.

A young girl with an uncommon renal tumour is the subject of this communication. A diagnosis of renal cell carcinoma was established post-operatively. Combined modality treatment including chemotherapy and radiotherapy has helped achieve a disease free survival of nearly 5 years.

Carcinoma, Renal Cell↗
PubMedDate not supplied

Facial nerve palsy in an infant with hemophilia A.

A 5-month-old infant with hitherto undiagnosed hemophilia A, who developed a unilateral lower motor neurone type of facial palsy, is described. A high-resolution CT scan confirmed the nerve palsy to be a consequence of a hemotympanum. The patient recovered completely in 7-10 days after therapy with factor VIII concentrate.

Facial Nerve↗
PubMedDate not supplied

Cytophotometric and cytogenetic analyses of mouse lymphomas.

Simultaneous cytophotometric and cytogenetic analyses of spontaneous mesenteric lymphomas from three female mice are reported. No statistically significant deviation from normal lymph node cells could be detected for any of the tumors with respect to nucleic acid content. However, all three tumors demonstrated trisomy as the major cytogenetic anomaly. Chromosome 7 or 8 was found to be the extra chromosome in two of the lymphomas while identification of chromosomes was not possible in the third.

Animals↗
PubMedDate not supplied

Juvenile T waves (a study of 100 normal subjects).

"Juvenile pattern" of T wave inversion in the precordial leads of electrocardiogram was studied in 100 normal healthy Indians of 0 to 70 years of age in both sexes. Incidence of such pattern was observed in 25 subjects upto 19 years of age. Persons of weight/height ratio less than 30% had higher incidence of juvenile T waves. Maximum incidence (48%) of juvenile T waves was observed in the annual income group of Rs. 15000/-. Exercise ECC showed slight flattening of the inverted T waves in V1 to V3 leads in eight subjects only.

Adolescent↗
PubMedDate not supplied

Cytogenetic analysis of an immunogenic mutant of the L5178Y lymphoma.

A mutant of the uniformly lethal L5178Y lymphoma, called the L5178Y/Manitoba (L5178Y/M), was rejected after subcutaneous challenge in syngeneic DBA/2 mice. Karyotypic analysis revealed that the parent L5178Y lymphoma had four chromosome markers, with the mutant L5178Y/M sharing one of them as well as possessing two distinguishing markers. One diploid and two hypotetraploid clones were isolated from the L5178Y/M; they contained all the marker chromosomes and were also rejected by the syngeneic host. In addition to the shared chromosome markers, the L5178Y/M possessed antigens in common with the parent L5278Y. DBA/2 mice made immune to the mutant by subcutaneous immunization were able to slow the growth of the parent tumor but not the unrelated P-815-X2 mastocytoma.

Animals↗