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Biomedical subjects

M Rasmussen

Publications and source records attributed to M Rasmussen.

116 records · Page 7Linked to original sources
PubMed1974

The acquisition of simple and compound sentence structure in an autistic child.

Contingent reinforcement and imitative prompts were used to teach an autistic child to use simple and compound sentences to describe a set of standard pictures. When imitative prompts and reinforcement were discontinued, correct use of simple sentences declined, but increased again when imitative prompts and reinforcement were re-instated. When imitative prompts and reinforcements were used to teach compound sentence structure, correct use of simple sentences declined and correct use of compound structure increased. At the end of training, the child also used novel compound sentences to describe a set of pictures on which he had received no direct training.

Autistic Disorder↗
PubMedDate not supplied

Management of postoperative pain in children undergoing orthopaedic surgery.

The aim of this study was to document how postoperative pain in children is managed routinely at a ward for orthopaedic surgery and to evaluate whether the treatment used is adequate. Children aged 6 to 14 years undergoing elective osteotomy at lower extremities were eligible. Information describing analgesic use preoperatively, perioperatively, and postoperatively for the first 3 days was collected. A direct self-reporting method was used to assess the children's experience of pain. Twenty-three children participated in the study. All children received analgesic treatment consisting of a central- and a peripheral-acting drug. As-needed administration was most common, and administered doses were often below the recommended doses. Of the children, 70% reported the experience of at least one episode of pain, and 26% experienced the worst pain they could imagine. It is still necessary to improve the care and efforts put into pain management.

Adolescent↗
PubMedDate not supplied

Intestinal retinol esterification and serum retinol in children with cystic fibrosis.

Children with cystic fibrosis (CF) often have a poor vitamin A status. We found in the present work a reduced level of serum retinol in older children with this disease. As retinol enters intestinal lymph as retinyl esters, the enzyme acyl-CoA:retinol acyltransferase (ARAT) may be of importance for retinol absorption. We have assayed ARAT activity in duodenal mucosal homogenate from children with CF. There was a large variation within the group. However, mean ARAT activity was not significantly decreased, as compared with controls. Thus, the lack of pancreatic enzymes probably is the main reason for reduced vitamin A absorption in CF. In celiac disease and in lactose intolerance--both mucosal disorders--a significant reduction of mean ARAT activity was found.

Acyltransferases↗
PubMedDate not supplied

Pain assessment of subcutaneous injections.

OBJECTIVE: To compare injection pain after subcutaneous administration of four different solution volumes. DESIGN: Double-blind, randomized, prospective, multiple crossover study. SETTING: Steno Diabetes Center, Gentofte, Denmark. PARTICIPANTS: Eighteen healthy volunteers, 9 women and 9 men, aged 21-30 years. METHODS: The subjects were injected with four different volumes (0.2, 0.5, 1.0, 1.5 mL) of NaCl 0.9%. The study was performed on 2 days with a 1-week washout period between the study days. On each study day the subjects received four injections in each thigh. To evaluate the validity of our pain assessing model the subjects received eight injections of 0.5% mL on one of the study days. Pain assessment was done immediately after each injection using both a 10-cm visual analog scale (VAS) and a six-item verbal rating scale (VRS). RESULTS: A significant difference in pain score on both the VAS (p < 0.05) and the VRS (p < 0.01) was seen between the four injection volumes. The pain was significantly increased with volumes of 1.0 and 1.5 mL. No significant difference in injection pain could be detected between 0.2 and 0.5 mL and between 1.0 and 1.5 mL. No significant period or carryover effect could be detected in the study. A significant correlation between the pain score on the VAS and the pain score on the VRS was found (r = 0.79, p < 0.0001). CONCLUSIONS: The pain of a subcutaneous injection is related to injection volume in the thigh. The results show that increasing the volume from 0.5 to 1.0 mL increases the pain significantly. The findings from this study should be considered when injection preparations for subcutaneous administration are formulated. The volume should generally be less than 1.0 mL if injected into the thigh.

Adult↗
PubMedDate not supplied

Nine pheochromocytomas in the same patient. Final mapping with ultrasound and angiography.

A 37-year-old man presented with hypertension and elevated urine catecholamine. Ultrasound scanning revealed a solid tumour of the right adrenal gland and two solid tumours in the retroperitoneum. The findings were confirmed with computed tomography and abdominal angiography. At surgery only the tumour of the right adrenal gland was removed. The histopathologic diagnosis was pheochromocytoma. Postoperatively the symptoms and biochemistry were unchanged and the patient was referred for further treatment. At ultrasonography and abdominal aortography 6 remaining tumours were demonstrated. Surgery was performed and 8 pheochromocytomas were extirpated (3 were closely spaced small tumours in a conglomerate corresponding to one of the visualized tumour sites). On histopathologic examination no signs of invasive growth were found. The patient recovered completely. The blood pressure was still normal 2 1/2 years later. Angiography and non-invasive examination of the entire abdomen and pelvis should be routine when pheochromocytomas are searched for.

Adrenal Gland Neoplasms↗