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Biomedical subjects

M Rashedi

Publications and source records attributed to M Rashedi.

32 records · Page 2Linked to original sources
PubMed1983

Development of the testes in female domestic fowls submitted to an experimental sex reversal during embryonic life.

The sex differentiation of the female chick embryo can be totally inverted toward the male sex by an early extraembryonic testis grafting. This sex reversal remains permanent, as shown by three adult fowls described in this paper. They possess two testes associated with normally differentiated male excretory ducts and their Müllerian ducts have regressed. The development of male sex characteristics such as external features, behavior and complete spermatogenesis is evidence that these cocks have endocrine and exocrine capabilities similar to those of normal cocks. Although these cocks were able to mate with female fowls, they were sterile. A mechanism is discussed by which grafted testes induce such modifications in females. Hypotheses considering the heterogametic sex (female in birds) as exerting a dominant influence on the phenotypic sexual differentiation can be discarded in light of our results because a homogametic testis provokes the definitive sex inversion of a female.

Animals↗
PubMed1980

[Thyroxin binding globulin (TBG) radioimmunoassay. Normal patients results according to age, and sex, and in the cases of dysthyroidisms (author's transl)].

The value of TBG serum concentration for the exploration of thyroid function was studied by radioimmunoassay in 203 patients (133 normals, 62 dysthyroidism, 8 women taking oral contraceptives). The results of the normal patients show important and as of yet unexplained variations of TBG levels, depending on age and sex. In hyperthyroidism, serum TBG was reduced significantly in women and no significantly in men. In hypothyroidism, the levels are significantly high in both sexes. Like the TRH test, the TBG serum concentration determination may be helpful for the diagnosis of a slight hypothyroidism. Moreover, as the serum levels return to normal values with substitutive therapy, TBG assay may be used as a follow-up test during the treatment of hypothyroid patients.

Adult↗
PubMed1979

[The treatment of Cushing's syndrome by selective excision of pituitary adenoma. 3 cases (author's transl)].

In three patients suffering from Cushing's disease, exploration revealed an enclosed pituitary adenoma in one case and a microadenoma in two cases. Selective excision via a transphenoidal approach resulted in cure of Cushing's disease as reflected by complete regression of clinical signs and the restoration of circadian rythm of cortisol. Regular follow-up over a period of more than two years showed the persistence of normal regulation of the corticotrophic sector of the pituitary.

Adenoma↗
PubMed1978

[Hormone of mullerian regression, inducing agent of the testis in chick embryo].

When embryonic testes are grafted in the coelom of female chick embryos, one observes significantly related effects on the mullerian ducts which regress more or less and on the gonads, with inhibition of the left ovary and eventual transformation of the right rudiment into a testes. The hormone responsible for mullerian regression is also a testes inductor.

Animals↗
PubMed1977

[Effect of cyclic AMP on retrogression of the Mullerian ducts in chick embryos].

Theophyllin and puromycine, inhibitors of the enzyme phosphodiesterase and AMPc are all able to inhibit the retrogression of mullerian ducts in the female chick embryo, grafted with an embryonic testis. We can think that these results are explained by an inhibitory action of AMPc on the mechanisms responsible for the mullerian retrogression. So the chick embryo reacts similarly as do the mammalian embryo.

Animals↗
PubMed1977

[Metyrapone test and plasma hormone estimations (author's transl)].

The usual metyrapone test based on the determination of the urinary steroid levels after ingestion of the product is relatively difficult to use because of its duration. In order to simplify this test, a comparative study was carried out with thirty subjects, 24 of whom were normal, by measuring their plasma hormonal levels by radioimmunoassay for ACTH, cortisol and aldosterone and by radiocompetition after extraction by carbon tetrachloride for the 11-desoxycortisol (S compound). The results show a parallel between the variation of the urinary steroid levels and the variations of plasma hormone levels during the first 24 hours of the test. Therefore, measuring the levels of ACTH, S compound and cortisol in the plasma before the ingestion of metyrapone and 24 hours afterwards seems simpler to carry out and accurate enough to test the integrity of the feed-back system between hypothalamus, pituitary and adrenal glands.

Adrenal Cortex Hormones↗
PubMed1976

[Inhibiting effect of the testis on the ovary of the chick embryo].

The testicular hormone responsible for the retrogression of the mullerian ducts in the female chick embryo submitted to an embryonic testicular graft, causes an atrophy of the two, cortical and medullary, parts of this gonad, which is more marked at the level of the cortex.

Animals↗