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Biomedical subjects

M R Simon

Publications and source records attributed to M R Simon.

At least 55 records · Page 3Linked to original sources
PubMed1982

Increased T cells lacking immunoglobulin Fc receptors and increased spontaneous morphological blast transformation in a patient with phycomycosis.

A 64-year-old diabetic man had phycomycotic infection with Rhizopus and expired following surgical debridement. Extensive immunological evaluation revealed normal cellular and humoral immune responses including an in vivo response to Rhizopus antigen following delayed hypersensitivity skin testing. Evidence for increased in vivo lymphocyte activation consisted of increased spontaneous morphological blast transformation and increased T non-mu non-gamma cells. This work extends the previous findings of normal immunological responsiveness including in vitro reactivity to Rhizopus antigen in such patients.

Antigens, Fungal↗
PubMed1982

Effects of experimental bipedalism on the growth of the femur and tibia in normal and hypophysectomized rats.

Male and female Sprague-Dawley rats were used to see if increased, intermittent, compressive forces, produced by experimental bipedalism would have a compensatory effect on hypophysectomy - a situation known to inhibit bone growth. Half of the rats underwent amputation of both front legs at 10 days of age; and at 21 days of age, half of the normal and half of the bipedal rats underwent hypophysectomy. All rats were sacrificed at 55 days of age, and weighed. The femora and tibiae were removed, cleaned, fixed, weighed and measured. The results of this study suggest that increased, intermittent, compressive forces may be instrumental in increasing long bone growth among adolescent females.

Animals↗
PubMed1982

Lymphocyte reactivity to Crohn's ileal homogenates.

This study was undertaken to demonstrate whether lymphocytes derived from patients with Crohn's disease and their household contacts would demonstrate increased reactivity upon exposure to tissue homogenates prepared from the terminal ileum of patients with Crohn's disease. It was demonstrated that 4 of 18 patients, 9 of 30 household contacts, and 0 of 13 control subjects exhibited statistically greater lymphocyte thymidine incorporation in response to Crohn's tissue homogenates (contacts vs control, P = 0.025) [Fisher Exact Test (FET)]. However, homogenates prepared from the terminal ileum of control subjects without inflammatory bowel disease also induced lymphocyte reactivity in 1 patient, 5 contacts, and 1 control subject. Factors may be present in homogenates prepared from human terminal ileum which induce lymphocyte reactivity in some patients with Crohn's disease and household contacts.

Adult↗
PubMed1981

Angiotensin-converting enzyme in Crohn's disease and ulcerative colitis.

The relationship between serum angiotensin-converting enzyme activity and inflammatory bowel disease was investigated in 37 patients who had Crohn's disease, 31 patients who had ulcerative colitis, and 104 control subjects. The enzyme activity tended to be depressed in Crohn's ileitis (P less than 0.05) and colitis, but not in Crohn's ileocolitis and ulcerative colitis. No increase in enzyme activity was observed in Crohn's disease ileum or colon or in ulcerative colitis colon. The granulomatous inflammation in Crohn's disease differs from that in sarcoidosis, in which striking elevation of angiotensin-converting enzyme is present in granulomatous tissue and frequently in serum.

Adult↗
PubMed1980

Kveim induced lymphocyte reactivity in patients and household contacts of patients with Crohn's disease.

In vitro lymphocyte thymidine uptake in response to validated Kveim antigen CR-1 was studied in 18 patients with Crohn's disease and in 30 of their household contacts. Two of the patients and 3 of the contacts demonstrated a stimulation index of 2 or greater. None of 15 control subjects demonstrated such reactivity. Lymphocytes from patient and household contact groups exhibited a greater mean increment in cpm than those from the control group (110, 130 and 33 cpm, respectively) (p < 0.05 and p < 0.005, respectively). This finding indicates a low level of lymphocyte reactivity to Kveim antigen in patients and in contacts, suggesting sensitization to Kveim antigen or to a cross-reacting antigen.

Adult↗
PubMed1979

Effect of nicotine on the development of fetal and suckling rats.

Nicotine, administered at a dose of 100 micrograms/kg/day from day 14 of gestation, did not affect maternal food intake, weight gain, length of gestation, litter size or fetal development; however, a daily dose of 1 mg/kg led to smaller litter size and higher incidence of stillbirth. Continued maternal administration of nicotine (100 micrograms/kg/day) until 12 days post partum did not affect newborn growth (body weight and length and size of heart and lung) during the first week after birth; during the second week, however, the nicotine-treated group lagged behind the controls. The stomachs of pups of nicotine-treated rats contained less food than those of controls; this difference increased with age, becoming more than 40% at 12 days. We suggest that lower milk production of nicotine-treated rats interferes with the normal development of the offspring during periods of rapid growth.

Animals↗
PubMed1978

The effect of dynamic loading on the growth of epiphyseal cartilage in the rat.

The Hueter-Volkmann law of epiphyseal pressures describes an inverse relationship between static compressive forces parallel to the axis of epiphyseal growth and the rate of growth of that cartilage. Studies of histological sections of the epiphyseal plate of the fourth metatarsals of (a) control, (b) bipedal and (c) bipedal rats with amputation of the fifth metatarsal show that dynamic compressive forces can stimulate epiphyseal cartilage growth. Within certain parameters, both the relief and increase of dynamic compression accelerate epiphyseal growth. It is the amount and kind of loading that are important factors to accelerate epiphyseal growth.

Age Factors↗
PubMed1977

Tuberculin-specific transfer factor in dogs.

Five mongrel dogs were sensitized to tuberculoprotein with Freund adjuvant, as determined by responses to tuberculin skin tests and by in vitro lymphocyte cultures. These animals served as blood donors for production of transfer factor. Nine mongrel dogs received single doses of transfer factor that was tuberculin specific. Successful transfer of tuberculin sensitivity as measured by lymphocyte transformations was achieved in five of nine animals. Canine lymphocyte cultures frequently showed relatively low transformations to mitogens as compared with responses noted in other animals. Dissociation between skin test reactivity and in vitro lymphocyte transformation to tuberculoprotein was noted in two of nine animals. Increases in lymphocyte transformations to phytochemagglutinin were seen in three of nine recipient animals after transfer factor administration. Successful transfer from an animal sensitized by prior transfer factor administration was achieved in one instance. These data indicate that transfer factor-like substances are present in dogs. The reasons why successful transfer was achieved in only half of the recipient animals needs further explanation.

Animals↗