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Biomedical subjects

M R Porter

Publications and source records attributed to M R Porter.

12 recordsLinked to original sources
PubMed2001

Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings.

OBJECTIVE: This study investigated whether cancer patients with and without major depression exhibit immune system abnormalities similar to those reported in medically healthy, depressed subjects without cancer. METHOD: The study subjects consisted of patients diagnosed with pancreatic, esophageal, or breast cancer. Other groups consisted of subjects with major depression (without cancer) and healthy comparison subjects. Subjects' diagnoses were made with the Structured Clinical Interview for DSM-III-R. Severity of depression was measured with the Hamilton Depression Rating Scale. Plasma concentrations of interleukin-6 (IL-6) and postdexamethasone cortisol were measured. RESULTS: Cancer patients with depression had markedly higher plasma concentrations of IL-6 than healthy comparison subjects and cancer patients without depression. Although significant correlations were found between Hamilton depression scale scores and plasma concentrations of postdexamethasone cortisol, no significant correlations were found between plasma IL-6 and postdexamethasone cortisol concentrations. CONCLUSIONS: Higher than normal plasma IL-6 concentrations were associated with a diagnosis of major depression in cancer patients. IL-6 may contribute to sickness behavior that has overlapping symptoms with major depression.

Adult↗
PubMed1996

Exaggerated platelet reactivity in major depression.

OBJECTIVE: This study investigated whether depressed patients exhibit exaggerated platelet reactivity. METHOD: In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge. RESULTS: The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12. CONCLUSIONS: Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction.

Adult↗
PubMed1995

Depression in patients with cancer. Diagnosis, biology, and treatment.

This article reviews the challenge of diagnosing depression in patients with cancer. Major depression and depressive symptoms, although commonly encountered in medical populations, are frequently underdiagnosed and undertreated. This is especially true for patients with cancer in whom the diagnosis of major depression is clouded by neurovegetative symptoms that may be secondary to either cancer or depression. Well-established biological markers for major depression are proposed as diagnostic adjuncts in patients with cancer. Studies using biological markers in depressed patients with and without cancer are reviewed, and the implications of diminished immune function in depressed patients with cancer are discussed. The limited database on treatment of depression in patients with cancer also is reviewed. Treatment of depression in these patients improves their dysphoria and other signs and symptoms of depression, improves quality of life, and may improve immune function and survival time. Guidelines for future research are proposed.

Biomarkers↗
PubMed1975

The importance of the Hanau formula in construction of complete dentures.

The casts of five patients whose kinematic mandibular axes had been previously located and tatooed on the face were mounted on six articulators (two of Denar D4-A, two of Whip-Mix, and two of Hanau model 130-28). The horizontal and lateral condylar guidances of all articulators were adjusted by using 15 interocclusal records (five protrusive and 10 right and left lateral) made in cold-curing acrylic resin. The adjustments for each articulator were repeated 20 times within five days. The lateral condylar guidances as adjusted by the interocclusal records were compared with those established by Hanau's formula. A significant difference in the means of the condylar readings occurred when the Hanau articulator was adjusted with a lateral interocclusal record and the Hanau formula. The range of means of lateral condylar guidances of Hanau articulators using the Hanau formula was small. This small possibility of variation in the lateral condylar guidance would suggest the use of lateral interocclusal records when precise restorative procedures are necessary. The Hanau formula is the only formula available at this time to determine the average lateral condylar guidance as related to the horizontal condylar guidance.

Dental Equipment↗