Search PubMed⌕ Search

Biomedical subjects

M R Phillips

Publications and source records attributed to M R Phillips.

At least 37 records · Page 2Linked to original sources

Economic reforms and the acute inpatient care of patients with schizophrenia: the Chinese experience.

OBJECTIVE: This study compared insured and uninsured schizophrenic inpatients in China and examined changes in the acute inpatient care of schizophrenic patients during China's economic reform era. METHOD: Detailed chart reviews of 50 randomly selected inpatients discharged from a hospital in central China each year from 1984 through 1993 identified 321 patients with schizophrenia. Demographic, insurance, treatment, and cost data of these patients were collected from the charts. RESULTS: With logistic regression models to control for confounding variables, the analyses showed that the 129 insured patients were significantly more likely than the 192 uninsured patients to be urban residents, to be older, to have had 7 or more years of schooling, and to have had more psychiatric hospitalizations; moreover, their index admissions were longer and were more likely to include use of traditional Chinese medications. The estimated 19% of schizophrenic individuals in the community with health insurance receive inpatient treatment 2.8 times more frequently than the 81% without insurance. Compared to admissions in 1984-1988, admissions in 1989-1993 were significantly shorter and involved longer periods of polypharmacy with multiple antipsychotic medications but included lower mean chlorpromazine-equivalent doses of medication. The relative cost of inpatient care for an acute episode of schizophrenia increased 3.5-fold over the 10-year period, from 11% of mean annual household income in 1984 to 37% in 1993. CONCLUSIONS: Changes in the incentive system for care providers and rapid increases in the cost of care during the economic reform era have resulted in increasingly restricted availability of services for the many schizophrenic patients without health insurance.

Adult↗

Comparison of techniques for implantation of aortic valve allografts.

BACKGROUND: Various implantation techniques for allograft aortic valve replacement have evolved over the years. Our objective was to examine the effects of different implantation methods on subsequent valve performance and durability. METHODS: Between May 1985 and January 1994, 137 patients underwent allograft aortic valve replacement. The first 59 aortic valve allografts were inserted by the freehand scalloped technique with removal of the aortic sinuses, and the last 78 valves were inserted by the cylinder technique, in which the aortic sinuses and sinotubular junction were retained. The mean age of the 91 men and 46 women was 53.7 years (range, 18 to 83 years). Preoperative diagnoses were aortic stenosis (n = 57), aortic regurgitation (AR, n = 40) and aortic stenosis/AR (n = 40); 27 patients had prior aortic valve operations and 1 patient had a previous heart transplantation. Active endocarditis was present in 29 patients. Associated procedures included coronary artery bypass (n = 33), ascending aneurysm repair (n = 4), left ventricular aneurysmectomy (n = 3), repair of atrial septal defect (n = 2), mitral valve repair or replacement (n = 6), and aortic root enlargement (n = 24). Follow-up was complete in 133 patients (97%) a mean of 4.9 years (range, 1 day to 9.8 years) after allograft aortic valve replacement. RESULTS: Operative mortality was 6.5% for all patients but only 1.9% for patients without infection having isolated aortic valve replacement. Early echocardiography (mean of 8.4 days postoperatively) demonstrated no AR or mild AR and a mean gradient of 10.6 +/- 6.2 mm Hg in all patients. The cumulative risk of development of grade III or IV AR at 7 years postoperatively was 26.2% +/- 6.3% in the scallop group and 12.4% +/- 5.6% in the cylinder group (p = 0.4). Late postoperatively, transvalvular gradient by echocardiography was 13.1 +/- 9.4 mm Hg, and was similar in the two study groups. Late AR led to reoperation in 13 patients (22%) who had initial implantation with the scallop method and only 4 patients (5.4%) who had the valve inserted with the cylinder method. However, because duration of follow-up was longer for patients in the scallop group, cumulative risk of reoperation was similar at 5 years postoperatively (scallop, 13.7% [95% confidence interval, 76.7% to 95.8%]; cylinder, 11.5% [95% confidence interval, 75.5% to 99.1%]). CONCLUSIONS: The insertion of an aortic valve allograft as a cylinder, retaining the sinotubular junction, appears to result in less aortic regurgitation at 7 years postoperatively, and with additional follow-up may result in less reoperation for AR.

Adolescent↗

Erotomanic symptoms in 42 Chinese schizophrenic patients.

BACKGROUND: Reports on erotomania frequently include schizophrenic patients with secondary erotomania, but there are no reports on the prevalence and characteristics of erotomanic symptoms in schizophrenic patients. METHOD: A structured item on erotomanic delusions was added to the Chinese version of the Scale for Assessment of Positive Symptoms and administered to 448 randomly selected schizophrenic patients on admission to four psychiatric hospitals in China. RESULTS: Erotomanic symptoms were identified in 9.4% of the patients (42/448; 95% CI 6.9-12.4%) 4.5% (20/448; CI 2.8-6.8%) had erotomanic ideation and 4.9% (22/448; CI 3.1-7.4%) had fixed erotomanic delusions. Compared with patients without erotomanic symptoms, erotomanic patients were more likely to be male and unmarried, and they had a higher level of education, more severe grandiose delusions, more prominent hostility, and less severe negative symptoms. CONCLUSION: The relatively common occurence of erotomanic symptoms in Chinese schizophrenic patients may be related to the indirect manner of expressing sexual interest in Chinese culture and, thus, be an example of the cultural moulding of psychiatric symptoms.

Adolescent↗

Intracardiac extension of an intracaval sarcoma of endometrial origin.

A 52-year-old woman was diagnosed with a cardiac tumor by transesophageal echocardiography and magnetic resonance imaging. An intraoperative biopsy indicated the mass was low-grade endometrial stromal sarcoma. Successful tumor removal from the heart and inferior vena cava was accomplished with the use of hypothermic circulatory arrest. The chronically occluded infrarenal portion of the inferior vena cava was transected. The patient has no evidence of recurrent disease after a follow-up of 18 months and has no significant restriction in her daily activities.

Biopsy↗

Family-based intervention for schizophrenic patients in China. A randomised controlled trial.

BACKGROUND: We developed and evaluated a comprehensive, ongoing intervention for families of schizophrenic patients appropriate for China's complex family relationships and unique social environment. METHOD: Sixty-three DSM-III-R schizophrenic patients living with family members were enrolled when admitted to hospital and randomly assigned to receive standard care or a family-based intervention that included monthly 45-minute counselling sessions focused on the management of social and occupational problems, medication management, family education, family group meetings, and crisis intervention. RESULTS: At 6, 12, and 18-month follow-ups by blind evaluators, the proportion of subjects rehospitalised was lower, the duration of rehospitalisation was shorter, and the duration of employment was longer in the experimental group than in the control group; these differences were statistically significant at the 12 and 18-month follow-ups and were not explained by differences in drug compliance. Family intervention was associated with significantly lower levels of family burden. CONCLUSIONS: This intervention is less costly than standard treatment, is suitable for urban families of schizophrenic patients in China and feasible given the constraints of the Chinese mental health system.

Adolescent↗

A rating instrument for the evaluation of in-patient rehabilitation programmes in China. Results of reliability and validity testing.

To objectively evaluate in-patient rehabilitation programmes in China, we developed a new rating scale: the Inpatient Psychiatric Rehabilitation Outcome Scale (IPROS). The scale has five subscales: performance in occupational therapy, daily activities, socialisation, personal hygiene, and level of interest in external events. Evaluators (physicians or nurses) observe patients for one week before coding items on a five-point scale. Comparison of four independent evaluators' results for 32 schizophrenic patients assessed on two separate occasions indicated that the inter-rater and test-retest reliability for the overall IPROS score and for the five subscale scores was excellent (all ICC values > or = 0.973). Validity was evaluated by comparing IPROS results with those of five other independently assessed clinical measures for 101 chronic schizophrenic patients before and after a six-month rehabilitation programme; concurrent validity and longitudinal validity were satisfactory (correlation coefficients 0.37-0.81, all P values < 0.01).

Activities of Daily Living↗

Community-based psychiatric rehabilitation in Shanghai. Facilities, services, outcome, and culture-specific characteristics.

This paper describes the community mental health services in Shanghai, analyses the effectiveness of these services, and discusses their culture-specific characteristics. It reports on a prospective, matched-control study of the three most important types of service: a community follow-up programme in psychiatric out-patient clinics at primary-level general hospitals, 'guardianship networks' operated by non-professional volunteers, and work therapy stations. In total 308 pairs of subjects completed the study. Using Chinese versions of the Disability Assessment Schedule to assess impairment in psychosocial functioning and the Present State Examination to assess the levels of positive and negative symptoms, ten blind evaluators who had excellent inter-rater reliability assessed the functioning of subjects at enrollment and every six months for the next two years. Over the two years, symptoms and social functioning improved in the treatment groups and deteriorated in the control groups. Thus these community psychiatric services have the dual benefit of promoting rehabilitation and preventing psychosocial deterioration.

Activities of Daily Living↗

Randomised-control trial of family intervention for 78 first-episode male schizophrenic patients. An 18-month study in Suzhou, Jiangsu.

At the time of discharge from their first stay in psychiatric hospital, 78 male schizophrenic patients were randomly assigned to a family intervention (experimental) group or a 'standard care' control group and were followed for the next 18 months. The family intervention consisted of both group and individual counselling sessions every 1-3 months that focused on education about the illness and on methods of dealing with the patient. There was a significantly lower rate of hospital readmission in the family intervention group than in the control group (15.4% versus 53.8%, chi 2 = 12.75, P < 0.01), and the mean hospital-free period for those who were readmitted was significantly longer in the experimental group than in the control group (245 days versus 130 days, t = 2.91, P < 0.01). Moreover, the clinical status and overall level of functioning in patients who were not readmitted were significantly better in experimental subjects than in control subjects. Stratified analysis showed that family intervention and regular use of medication had independent and additive effects on the outcome. During the 18 months after the index discharge patients who did not take medication regularly and who did not receive family intervention were 7.9 times as likely to be readmitted to hospital as patients who took medication regularly and received family intervention.

Adolescent↗

Computerized psychiatric diagnoses based on euclidean distances: a Chinese example.

Current diagnostic methods in psychiatry use sequential logical decision rules that generate a single diagnosis. Insufficient attention has been paid to parallel methods that can simultaneously determine the relative probability of many diagnoses. This study installed 45 items from various symptom scales on a portable computer and applied a euclidean distance formula to generate immediate diagnoses based on responses to the items. The reliability and validity of the method were assessed using Chinese psychiatric inpatients. Interrater reliability was excellent (kappa = 0.91) and 3-week test-retest reliability was fair (k = 0.50). The concordance of this method with clinicians' diagnoses and with diagnoses based on standardized Chinese diagnostic criteria was excellent (k = 0.73 and 0.76). Concordance with DSM-III-R diagnoses and ICD-10 diagnoses was fair (kappa = 0.55 and 0.65). The clinical utility of such parallel methods of psychiatric diagnosis deserves further evaluation.

Bipolar Disorder↗

Transfusion medicine in the 1990s, why it has changed and how.

This paper is intended for physicians not directly responsible for transfusion medicine in their everyday practices. The field has changed dramatically in the last decade. This paper attempts to outline these changes, and detail factors that will be of practical use in general, medical, and surgical practices. Topics include available blood products with indications and risks, education about types of blood donation, possible future products, and a key concept in the field today, "conservation."

Blood Component Transfusion↗

Reliability and validity of the Chinese versions of the Scales for Assessment of Positive and Negative Symptoms.

This 4-center study assesses the reliability and validity of the Chinese versions of the Scale for Assessment of Positive Symptoms and the Scale for Assessment of Negative Symptoms. Interrater reliability, short-term test-retest reliability, and internal consistency were excellent; intraclass correlation coefficients and Cronbach alphas for the overall scores were all over 0.8. The strong correlation of the scales with an independently assessed parallel measure (the Chinese version of the Brief Psychiatric Rating Scale) and the separate positive and negative factors found with principal components analysis confirm the construct validity of the instruments. These findings demonstrate the importance of culturally sensitive revision and rigorous psychometric evaluation of Western instruments prior to their use in non-Western cultures.

Adolescent↗