Biomedical subjects
Publications and source records attributed to M R Pai.
Pleomorphic xanthoastrocytoma is an unusual brain tumour of children with a favourable prognosis. The tumour takes origin from subpial astrocytes of the cerebral cortex. Histologically proliferation of spindle cells, mono and multinucleated giant cells containing lipid droplets and the absence of necrosis are distinctive features. Herein we report the morphological and immunophenotypical features of a case of pleomorphic xanthoastrocytoma.
Explore the source record for details and available documents.
Nongestational choriocarcinoma is an extremely rare malignant tumour of the ovary. It may be pure or combined with other germ cell tumours. A case of nongestational choriocarcinoma with mature cystic teratoma is presented herewith.
Three cases of angiomatoid fibrous histiocytoma of the lower extremity are described. All the three patients were young and gave a history of swelling of 1-5 years duration. Histologically, the lesions were characterised by the presence of large blood filled spaces lacking endothelial lining, being surrounded and lined by sheets of proliferating histiocytes, many of which contained haemosiderin pigment.
Primary retroperitoneal neoplasia is not a common condition. Out of the 34 tumours analysed in the present study 15 were germ cell tumours, 10 were soft tissue tumours and 9 were tumours of the sympathetic nervous system. Among the 15 germ cell tumours, 9 were mature teratomas while there were 2 each of immature teratoma, embrayonal carcinoma and dysgerminoma. Out of the 10 soft tissue tumours 9 were sarcomas with 5 liposarcomas, 3 leiomyosarcomas and 1 neurogenic sarcoma. The only benign soft tissue tumour was a lipoma. The 9 tumours of the sympathetic nervous system included 7 neuroblastomas and 2 ganglioneuroblastomas. Overall, in the present series majority of the primary retroperitoneal tumours (22 out of 34 i.e. 70.6%) were malignant tumours.
Three cases of rhinoentomophthoromycosis involving the nasal region are presented diagnosis in the first two cases was made on surgical biopsy and in the third case by fine needle aspiration biopsy. A granulomatous inflammatory reaction was seen in tissue around hollow broad hyphae of the fungus. The hyphal strands were surrounded by eosinophilic deposits Splendore--Hoeppli phenomenon.
Explore the source record for details and available documents.
Though an increasing number of chemotherapy- and radiotherapy-related leukaemias are being reported, acute promyelocytic leukaemia developing as a therapy-related second malignancy is still uncommon. Here we report a case of acute promyelocytic leukemia, microgranular variant, developing in a case of intracranial malignant ependymoma, 1.5 years following treatment with craniospinal radiotherapy.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Glucose metabolism in Mycobacterium smegmatis was investigated by the radiorespirometric method and by assaying for key enzymes of the major energy-yielding pathways. Glucose is oxidized in this organism mainly through the Embden-Meyerhof-Parnas pathway, irrespective of the carbon source used for growth. The pentose phosphate pathway plays only a minor role and its extent depends on the carbon source used for growth. Enzymes of glycolytic and oxidative pathways were detected in cells grown on glucose, glycerol, or pyruvate but enzymes of the Entner-Duodroff pathway could be detected only in glucose-grown cells. Labeled acetate is utilized by cells cultured on glucose, glycerol, and pyruvate. In all cases more of C1 of acetate was converted to CO2 while incorporation into cellular constituents was maximum from C2 of acetate.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Aspergillus flavus NRRL 3251 grown on modified yeast extract-sucrose medium produced 1 mg of aflatoxin M(1) per 100 ml of medium.