Search PubMed⌕ Search

Biomedical subjects

M R Morris

Publications and source records attributed to M R Morris.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Chondrosarcoma of the temporomandibular joint: case report.

Chondrosarcoma of the head and neck region is a rarely encountered tumor. Aggressive surgical excision offers the best chance for cure. In our case, combined diagnostic techniques consisting of fine needle aspiration (FNA), computed tomography (CT), and magnetic resonance imaging (MRI) made an accurate preoperative assessment possible and greatly influenced the treatment provided.

Adult↗
PubMedDate not supplied

Phase I clinical evaluation of a new iron oxide MR contrast agent.

The safety and magnetic resonance (MR) imaging potential of BMS 180549, a new superparamagnetic iron oxide contrast agent, were evaluated in a phase I, open-label, placebo-controlled study involving 41 healthy subjects. No clinically significant postdose changes in physical examination findings, vital signs, or electrocardiogram results were reported for any of the subjects evaluated. No clinically significant changes in clinical laboratory values were noted by the investigators. Fourteen adverse events considered not serious and considered possibly or definitely related to the drug were reported, three of which required minor treatment. Relaxation time measurements in plasma samples showed a strong, dose-dependent, and persistent decrease in T1 and T2 values. Significant changes in MR signal intensity of the blood pool and well-perfused organs (liver and spleen) were noted on both T1- and T2-weighted images. Changes in signal intensity of cervical lymph nodes were also observed at the higher doses and late postdose imaging times.

Adult↗
PubMedDate not supplied

A critical review of radiotherapy in the management of T1 glottic carcinoma.

INTRODUCTION: It is generally believed that patients presenting with T1 glottic cancer can be treated with either surgery or radiation therapy (RT) with similar expectations relative to tumor control. Accordingly, many institutions routinely treat patients with T1 glottic cancer with RT. This retrospective study was undertaken to ascertain the efficacy of RT in the treatment of these patients. MATERIALS AND METHODS: The records of 40 patients initially treated with RT between 1974 and 1989 were retrospectively reviewed. Parameters assessed included incidence of tumor control, need for and type of subsequent salvage surgical procedures, quality of voice, and ultimate survival rate. RESULTS: In a group of 38 evaluable patients, 10 (26%) developed recurrence in the larynx and 2 (5.6%) in the cervical lymphatics. Salvage surgery resulted in 6 (16%) total laryngectomies. Death from T1 glottic cancer occurred in 1 (2.6%) patient. Speech results were judged good in 24% of patients, whereas 66% were felt to have impaired speech with elements of glottic fry, harshness, low pitch, and inefficient breath support. The additional costs incurred by patients requiring subsequent intervention are substantial. CONCLUSION: Cordectomy may be a superior option for management of T1 glottic cancer. Initial tumor control is probably superior and literature review suggests that surgery may be a more economical option and should be seriously considered for the management of T1 glottic cancer. This is a US government work. There are no restrictions on its use.

Carcinoma in Situ↗