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Biomedical subjects

M R Moore

Publications and source records attributed to M R Moore.

At least 217 records · Page 12Linked to original sources
PubMed1980

Oral absorption of lead and iron.

Oral lead and iron absorptions have been measured by the use of radioactive tracer techniques in ten subjects, five of whom had low iron stores as shown by low serum ferritin. The absorption of both elements was abnormally high in these five and also in one subject with normal serum ferritin. The other 4 subjects, who were iron-replete, had absorption values in the normal range. The statistically significant positive correlation between oral lead and iron absorptions suggests that the sizeable proportion of the population "overabsorbing" iron may absorb two to three times more lead than the generally accepted value of 10% of dietary input.

Adult↗
PubMed1980

Effects of delta-aminolaevulinic acid on contractile activity of rabbit duodenum.

delta-Aminolaevulinic acid (ALA) inhibited spontaneous contractions and contractions induced by acetylcholine, barium chloride or ouabain in rabbit duodenum preparations suspended in Ringe-Locke solution. Concentrations of ALA between 25--100 micrograms/ml reduced amplitude of spontaneous contractions and at levels above 200 micrograms ALA/ml spontaneous contractions caused. Muscle tone was decreased in proportion to logarithm of AL concentration between 25 and 1000 micrograms/ml. Gut ALA levels were increased by the treatment and returned to control values after washing, and pharmacological effects were full reversed. Neither tetrodotoxin nor atropine affected the gut's response to ALA. The response still occurred in calcium-free, high-calcium, potassium-free and high-potassium bathing fluid. Effects of ouabain resembled those of ALA only when gut had been pretreated with atropine; pretreatment with tetrodotoxin induced slight contracture. The observed pharmacological effects of ALA must be by actions additional to sodium pump inhibition.

Acetylcholine↗
PubMed1980

Serum alpha-fetoprotein and human chorionic gonadotropin in patients with seminoma.

We analyzed the case histories of 31 patients who initially had a diagnosis of seminoma and elevated serum levels of alpha-fetoprotein or human chorionic gonadotropin. We concluded that an elevated alpha-fetoprotein level is firm evidence of the presence of non-seminomatous germ cell tumor and that the patient should be treated accordingly. However, if the level of human chorionic gonadotropin alone is elevated the diagnosis may be either non-seminomatous tumor or seminoma. Patients with seminoma and an elevated level of human chorionic gonadotropin do respond well to radiation therapy if they have low stage disease but if metastatic seminoma is present an elevated human chorionic gonadotropin level appears to be a poor prognostic sign if conventional treatment is given. A plan of treatment is proposed for these patients.

Adult↗
PubMed1980

Induction of delta-aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy--comparison with changes in rat hepatic tissue.

1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta-aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem-requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.

5-Aminolevulinate Synthetase↗
PubMed1980

Acute ethanol ingestion and haem biosynthesis in healthy subjects.

The effects of acute ethanol ingestion on the activities of the enzymes of haem biosynthesis in peripheral blood cells have been monitored in eight healthy subjects. The mitochondrial enzymes delta-aminolaevulinic acid (ALA) synthase, coproporphyrinogen oxidase and ferrochelatase were measured in leucocytes and the cytosolic enzymes ALA dehydratase, porphobilinogen (PBG) deaminase and uroporphyrinogen decarboxylase in erythrocytes. Ingestion of 1 . 316 mol ethanol resulted in increased activity of the rate-controlling enzymes ALA synthase and PBG deaminase and decreased activity of the other four enzymes. There was also increased urinary excretion of coproporphyrin. These observations may be relevant to the biochemical mechanisms involved in the ethanol-related conditions, sideroblastic anaemia, cutaneous hepatic porphyria and hepatic siderosis.

5-Aminolevulinate Synthetase↗
PubMed1980

Blood-lead and cadmium in human hypertension.

An epidemiological study amongst hypertensives and normotensives in Renfrew, Scotland, where drinking water hardness is very low (5 p.p.m.) and water-lead levels are commonly high, has shown a significant association between high blood-lead levels and high blood pressure. No association was found with indices of renal function, plasma renin or angiotensin II concentrations or serum uric acid levels. In a parallel study of blood-lead levels in Birmingham, England, where water hardness is low (20 p.p.m.) but water-lead levels are also low, high blood-lead levels were not found, no relationship was found with blood pressure and the prevalence of hypertension was lower than in Renfrew. We conclude that sub-clinic lead exposure from drinking water may be a factor in the development of hypertension. A study of blood-cadmium levels has shown no association between high blood pressure and sub-clinical cadmium exposure, but confirmed a close relation between blood-cadmium and cigarette smoking. We conclude that previous reports of a cadmium-blood pressure link may be confounded by failure to allow for the cigarette smoking habits of the subjects studied.

Adult↗