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Biomedical subjects

M R Gardner

Publications and source records attributed to M R Gardner.

8 recordsLinked to original sources
PubMed2001

Understanding and caring for the child with Asperger syndrome.

Nurses in a variety of settings encounter children with the unfamiliar diagnosis of Asperger syndrome (AS). This disorder, which falls clinically along the autism spectrum, is receiving increasing attention because of its inclusion in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) as one of the pervasive developmental disorders. The characteristic features of AS include deficits in social skills, atypical understanding of and use of pragmatic language, behavior problems, and a restricted set of interests. Cognitive abilities vary, and some children with AS have high intelligence. In addition, many children with AS have other conditions, such as attention deficit hyperactivity disorder, Tourette's syndrome, obsessive-compulsive disorder, and depression. The disorder can result in significant functional difficulties in the home, school, and community contexts. A case study highlights the features of AS, and a related individualized school health care plan demonstrates the school nurse's role in family and staff education, monitoring for comorbidities, behavioral management, medication management, support to family members, and referral.

Asperger Syndrome↗
PubMed1994

Is that a fact? Empiricism revisited, or a psychoanalyst at sea.

In this paper, the author has tried to illustrate a few of the long, tortuous, and illusive workings by which an analyst, in constructing the configurations called 'facts', tries to combine the perspectives, traditions, and methods of humanism and science, and to move from the subjectivities of observation, character, experience, and theory toward the goal of a relatively informed subjectivity. He has tried in particular to illustrate: (1) Characteristic sequences of trial and error, and some events of observation of self and other, that lead again and again to corrections, modifications, and expansions of our previous constructions of 'facts'. (2) Aspects of our struggles to find ways to be guided by our theories and our other suppositions and predilections, but to the degree possible, when possible, not driven. (3) Aspects of a personal perspective--attention to a patient's hidden questions--by which the author tries to identify facts of the surface that may help him to help his patients to advance their self inquiries and to bridge to some facts of the depths that have contributed to the shape of those facts of the surface.

Adult↗
PubMed1990

Nonrashes. 6. Telepathic pruritus.

We report the case of a paranoid schizophrenic man who suffered from the delusion that two other men used mental telepathy to make him itch over a period of thirteen years. To our knowledge, this is the first report of "telepathic pruritus."

Delusions↗
PubMed1982

Predictions of stability in pharmaceutical preparations XIX: Stability evaluation and bioanalysis of clofibric acid esters by high-pressure liquid chromatography.

Specific, sensitive, reversed-phase high-pressure liquid chromatographic assays of clofibric acid esters, clofibrate and etofibrate, and their hydrolysis products, clofibric acid and its monoglycolate and nicotinic acid and its monoglycolate, have been developed in aqueous solution and in biological fluids. Sensitivities of 100 ng/ml of injected mobile phase, a 10-fold increase over existing methods, are reported. Plasma concentrations as low as 200 ng/ml can be analyzed easily in the miscible phase after acetonitrile denaturation. The compounds and their products can be extracted with haloalkane solvents. The extracts were evaporated, reconstituted, and assayed in minimal amounts of mobile phase, resulting in sensitivities of 10 ng/ml of plasma. Conditions are presented that minimize interferences with plasma components. The assay was used to determine the stability of the clofibric acid esters in aqueous solutions, to establish log k-pH profiles at various temperatures, and to evaluate Arrhenius parameters. Hydrolysis was by specific acid-base catalysis. The initial product of etofibrate solvolysis at pH greater than 6 is the monoglycol ester of clofibric acid; at pH less than 3, it is the monoglycol ester of nicotinic acid. Clofibric acid esters are highly unstable to mild alkali (1-3 hr at pH 10 and 30 degrees); even in the estimated pH range of maximum stability, they have half-lives of 100-200 days at 30 degrees. They have half-lives of 4-7 min at 37.5 degrees in fresh dog plasma, and data presented indicate that clofibric acid monoglycolate is an initial product of etofibrate solvolysis.

Animals↗