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Biomedical subjects

M R Gamble

Publications and source records attributed to M R Gamble.

3 recordsLinked to original sources

Fire alarms and oestrus in rats.

Vaginal smear cyclicity was used as a physiological test to compare the response of rats to the new "silent" fire alarm developed by the Laboratory Animals Centre with a conventional fire bell. The fire bell had a highly significant effect on the vaginal smear cyclicity whereas the rats exposed to the "silent" fire alarm showed no significant changes from the control animals in quiet conditions.

Animals

Ammonia build-up in animal boxes and its effect on rat tracheal epithelium.

Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the tracheal epithelium of rats, and it is suggested that 'abnormal respiratory histology" could be a reflection of the standard of husbandry employed before and during an experiment.

Ammonia